Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0019 | 0.1334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1334 | 0.2945 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.1334 | 1 |
Brugia malayi | hypothetical protein | 0.0031 | 0.3157 | 0.6968 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0032 | 0.3416 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0032 | 0.3416 | 1 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0072 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.505 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0015 | 0.0519 | 0.0519 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0019 | 0.1334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1334 | 0.2945 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0031 | 0.3157 | 0.3157 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0039 | 0.4531 | 0.4531 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0015 | 0.0519 | 0.0519 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0015 | 0.0527 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.1334 | 0.2945 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.3157 | 0.6252 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0015 | 0.0519 | 0.0519 |
Onchocerca volvulus | 0.0019 | 0.1334 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Echinococcus granulosus | voltage gated potassium channel | 0.0015 | 0.0519 | 0.0519 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0031 | 0.3157 | 0.3157 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0019 | 0.1334 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0039 | 0.4531 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0019 | 0.1334 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0.1334 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.1334 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.505 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0015 | 0.0519 | 0.1028 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0039 | 0.4531 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0015 | 0.0519 | 0.1028 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.1334 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.1334 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0019 | 0.1334 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0015 | 0.0527 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0031 | 0.3157 | 0.6252 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.1334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3785 | 0.8354 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0015 | 0.0527 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0019 | 0.1334 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0015 | 0.0519 | 0.1145 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0039 | 0.4531 | 0.4531 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1334 | 0.2945 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0015 | 0.0527 | 0.139 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0519 | 0.1145 |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.1334 | 0.2945 |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.1334 | 0.2945 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.