Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0053 | 0.2656 | 0.2656 |
Onchocerca volvulus | 0.0141 | 1 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0053 | 0.2656 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0053 | 0.2656 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0053 | 0.2656 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0043 | 0.1803 | 0.1803 |
Schistosoma mansoni | tar DNA-binding protein | 0.0053 | 0.2656 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0053 | 0.2656 | 1 |
Brugia malayi | RNA binding protein | 0.0053 | 0.2656 | 0.2656 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0021 | 0 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0053 | 0.2656 | 0.2656 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0053 | 0.2656 | 0.2656 |
Loa Loa (eye worm) | RNA binding protein | 0.0053 | 0.2656 | 0.2656 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0053 | 0.2656 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0043 | 0.1803 | 0.1803 |
Echinococcus multilocularis | tar DNA binding protein | 0.0053 | 0.2656 | 1 |
Brugia malayi | TAR-binding protein | 0.0053 | 0.2656 | 0.2656 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.