Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1274 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.0765 | 0.2852 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0765 | 0.2852 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1295 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1274 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.1295 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1295 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0765 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1295 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1274 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.1274 | 0.9706 | 0.9604 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1295 | 1 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0765 | 0.2852 | 0.5 |
Onchocerca volvulus | 0.1295 | 1 | 0.5 | |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1274 | 0.9706 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1295 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1295 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0765 | 0.2852 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 160 uM | Inhibitory activity was determined against 9-cis-epoxycarotenoid dioxygenase (NCED) expressed in E. coli in presence of 9''-cis-neo-xanthin | ChEMBL. | 15149639 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.