Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuromedin B receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | neuromedin B receptor | 390 aa | 386 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1382 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0816 | 0.2852 | 0.5 |
Onchocerca volvulus | 0.1382 | 1 | 0.5 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1359 | 0.9706 | 0.9706 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0816 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1382 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0816 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1359 | 0.9706 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.0816 | 0.2852 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0816 | 0.2852 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1359 | 0.9706 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1382 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1359 | 0.9706 | 0.9604 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1382 | 1 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1359 | 0.9706 | 0.9706 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1382 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 603 nM | Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate | ChEMBL. | 15149640 |
EC50 (functional) | = 603 nM | Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate | ChEMBL. | 15149640 |
IC50 (binding) | = 0.32 uM | Affinity of [125I]-[D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells | ChEMBL. | 15149640 |
IC50 (binding) | = 0.32 uM | Affinity of [125I]-[D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells | ChEMBL. | 15149640 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.