Detailed information for compound 170089

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 815.956 | Formula: C39H61N9O10
  • H donors: 11 H acceptors: 10 LogP: -1.38 Rotable bonds: 30
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC(C[C@@H](C(=O)N[C@H](C(=O)N)CCC(C)C)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](CC(=O)O)N)C
  • InChi: 1S/C39H61N9O10/c1-19(2)12-13-27(34(41)53)45-36(55)28(14-20(3)4)44-30(50)18-43-38(57)32(21(5)6)47-37(56)29(15-23-17-42-26-11-9-8-10-24(23)26)46-39(58)33(22(7)49)48-35(54)25(40)16-31(51)52/h8-11,17,19-22,25,27-29,32-33,42,49H,12-16,18,40H2,1-7H3,(H2,41,53)(H,43,57)(H,44,50)(H,45,55)(H,46,58)(H,47,56)(H,48,54)(H,51,52)/t22-,25+,27+,28+,29+,32+,33+/m1/s1
  • InChiKey: BYUHQCHCIBRILN-MGHFTIBRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tubulin beta 1 chain 0.0093 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0415 0.0495 0.0495
Trypanosoma cruzi Aminopeptidase M1, putative 0.0581 0.0708 1
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0432 0.0518 0.2344
Echinococcus granulosus dnaJ subfamily B 0.0433 0.0518 0.0518
Brugia malayi Calcitonin receptor-like protein seb-1 0.1312 0.1642 0.2717
Trypanosoma brucei cdc2-related kinase 1 0.005 0.0029 0.0327
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.012 0.0118 0.0118
Echinococcus multilocularis glutamate receptor 2 0.0051 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Trichomonas vaginalis endoplasmin, putative 0.0081 0.0069 0.0311
Entamoeba histolytica aminopeptidase, putative 0.0581 0.0708 1
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Echinococcus granulosus cyclin b3 0.0104 0.0098 0.0098
Trypanosoma cruzi heat shock protein 85, putative 0.0172 0.0184 0.2605
Loa Loa (eye worm) G-protein coupled receptor 0.1053 0.1311 0.3445
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1053 0.1311 0.1311
Echinococcus granulosus biogenic amine 5HT receptor 0.1053 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.0432 0.0518 0.136
Echinococcus multilocularis rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Mycobacterium ulcerans adenosine deaminase 0.0085 0.0074 0.0193
Toxoplasma gondii aminopeptidase N protein 0.0204 0.0226 0.1023
Echinococcus granulosus cyclin dependent kinase 1 0.005 0.0029 0.0029
Brugia malayi larval opioid receptor 0.1053 0.1311 0.2169
Schistosoma mansoni amine GPCR 0.1053 0.1311 0.1311
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0036
Schistosoma mansoni tubulin subunit beta 0.0093 0.0083 0.0083
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0204 0.0226 0.0226
Plasmodium falciparum plasmepsin VIII, putative 0.0432 0.0518 0.2344
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0008 0.0008
Echinococcus granulosus cyclin dependent kinase 5 0.005 0.0029 0.0029
Trichomonas vaginalis heat shock protein, putative 0.0145 0.015 0.0679
Plasmodium vivax cysteine repeat modular protein 1, putative 0.004 0.0015 0.0068
Brugia malayi follicle stimulating hormone receptor 0.1966 0.2478 0.4101
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0113 0.0109 0.0493
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0009 0.0009
Brugia malayi Protein kinase domain containing protein 0.0049 0.0027 0.0045
Echinococcus multilocularis rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Giardia lamblia Kinase, CMGC CDK 0.005 0.0029 0.0637
Echinococcus granulosus cyclins 0.0104 0.0098 0.0098
Brugia malayi hypothetical protein 0.1053 0.1311 0.2169
Trichomonas vaginalis heat shock protein, putative 0.0172 0.0184 0.0835
Mycobacterium leprae 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) 0.2458 0.3107 1
Onchocerca volvulus 0.0039 0.0014 0.0083
Schistosoma mansoni hypothetical protein 0.0433 0.0518 0.0518
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0014 0.0063
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0104 0.0098 0.0098
Echinococcus multilocularis g-protein coupled receptor 0.1053 0.1311 0.1311
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.005 0.0029 0.0075
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0145 0.015 0.015
Brugia malayi hypothetical protein 0.0432 0.0518 0.0856
Schistosoma mansoni endoplasmin 0.0172 0.0184 0.0184
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0008 0.0008
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0581 0.0708 0.0708
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Plasmodium vivax tubulin beta chain, putative 0.0093 0.0083 0.0375
Echinococcus granulosus glutamate receptor subunit protein glur 0.0034 0.0008 0.0008
Echinococcus multilocularis Tubulin beta 2C chain 0.0093 0.0083 0.0083
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1053 0.1311 0.1311
Toxoplasma gondii heat shock protein HSP90 0.0172 0.0184 0.0835
Toxoplasma gondii hypothetical protein 0.0079 0.0066 0.0296
Toxoplasma gondii exonuclease III APE 0.0039 0.0014 0.0062
Loa Loa (eye worm) beta-lactamase 0.0039 0.0014 0.0036
Echinococcus multilocularis glutamate receptor 2 0.0034 0.0008 0.0008
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0084 0.0084
Brugia malayi RE15519p 0.1053 0.1311 0.2169
Schistosoma mansoni histamine h1 receptor 0.1053 0.1311 0.1311
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1053 0.1311 0.1311
Schistosoma mansoni tubulin subunit beta 0.0093 0.0083 0.0083
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Trypanosoma cruzi aminopeptidase, putative 0.0204 0.0226 0.319
Giardia lamblia Beta tubulin 0.0093 0.0083 0.2941
Trichomonas vaginalis cyclin B, putative 0.0222 0.0249 0.1126
Echinococcus granulosus cyclin dependent kinase 0.005 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0057 0.0038 0.01
Loa Loa (eye worm) tubulin beta-1 chain 0.0093 0.0083 0.0218
Toxoplasma gondii ABC1 family protein 0.0039 0.0014 0.0062
Brugia malayi Dopamine receptor protein 1 0.1053 0.1311 0.2169
Plasmodium vivax aspartyl protease, putative 0.0432 0.0518 0.2344
Schistosoma mansoni hypothetical protein 0.0415 0.0495 0.0495
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0014 0.0063
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.1755 0.2208 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0052 0.0591
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0377 0.0447 0.1174
Echinococcus granulosus heat shock protein 90 0.0145 0.015 0.015
Brugia malayi proprotein convertase 2 0.009 0.008 0.0132
Brugia malayi Hsp90 protein 0.0054 0.0034 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0052 0.0591
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0288 0.0333 0.0875
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0067 0.005 0.005
Echinococcus granulosus Tubulin beta 2C chain 0.0093 0.0083 0.0083
Trypanosoma brucei heat shock protein 90, putative 0.0172 0.0184 0.2104
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Echinococcus multilocularis 0.0116 0.0112 0.0112
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0047 0.0212
Plasmodium vivax SET domain protein, putative 0.0067 0.005 0.0226
Brugia malayi hypothetical protein 0.1053 0.1311 0.2169
Brugia malayi Dopamine receptor 0.1053 0.1311 0.2169
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0432 0.0518 0.136
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0047 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0084 0.0383
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0047 0.0047
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1966 0.2478 0.6514
Giardia lamblia Kinase, PLK 0.0094 0.0084 0.301
Plasmodium falciparum plasmepsin VII 0.0432 0.0518 0.2344
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0432 0.0518 0.0517
Brugia malayi hypothetical protein 0.0204 0.0226 0.0374
Loa Loa (eye worm) hypothetical protein 0.0353 0.0416 0.1093
Trypanosoma brucei heat shock protein, putative 0.0172 0.0184 0.2104
Schistosoma mansoni cyclin B 0.0222 0.0249 0.0249
Echinococcus multilocularis cpg binding protein 0.0032 0.0006 0.0006
Schistosoma mansoni alpha-1 adrenergic receptor 0.1053 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0029 0.013
Onchocerca volvulus 0.0204 0.0226 0.1364
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0087 0.0075 0.4511
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Brugia malayi latrophilin 2 splice variant baaae 0.0897 0.1111 0.1839
Echinococcus multilocularis G-protein coupled receptor, putative 0.1053 0.1311 0.1311
Onchocerca volvulus 0.0581 0.0708 0.4274
Schistosoma mansoni biogenic amine (5HT) receptor 0.1053 0.1311 0.1311
Schistosoma mansoni tyrosine kinase 0.0083 0.007 0.007
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.1755 0.2208 0.2208
Trichomonas vaginalis cyclin A, putative 0.0222 0.0249 0.1126
Loa Loa (eye worm) TATA binding protein associated factor 0.0204 0.0226 0.0594
Plasmodium falciparum SET domain protein, putative 0.0067 0.005 0.0226
Toxoplasma gondii histone lysine methyltransferase SET8 0.0067 0.005 0.0226
Echinococcus multilocularis cyclins 0.0104 0.0098 0.0098
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1053 0.1311 0.1311
Schistosoma mansoni hypothetical protein 0.1053 0.1311 0.1311
Trypanosoma cruzi heat shock protein 90, putative 0.0118 0.0115 0.1622
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0432 0.0518 0.0517
Echinococcus multilocularis fmrfamide receptor 0.1053 0.1311 0.1311
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.005 0.0029 0.013
Echinococcus multilocularis neuropeptide receptor 0.1053 0.1311 0.1311
Echinococcus multilocularis sex peptide receptor 0.1053 0.1311 0.1311
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0415 0.0495 0.0495
Schistosoma mansoni amine GPCR 0.1053 0.1311 0.1311
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0087 0.0075 0.0198
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0008 0.0035
Trypanosoma brucei heat shock protein, putative 0.0172 0.0184 0.2104
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0377 0.0447 0.1174
Schistosoma mansoni cyclin B3 0.0104 0.0098 0.0098
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0288 0.0333 0.0551
Schistosoma mansoni biogenic amine receptor 0.1053 0.1311 0.1311
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0206 0.0934
Echinococcus granulosus epidermal growth factor receptor 0.0083 0.007 0.007
Brugia malayi beta-lactamase 0.0039 0.0014 0.0023
Brugia malayi glutaminase DH11.1 0.0564 0.0685 0.1134
Echinococcus multilocularis G protein coupled receptor 139 0.7848 1 1
Brugia malayi Furin-like cysteine rich region family protein 0.0154 0.0161 0.0267
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0054 0.0034 0.0481
Schistosoma mansoni lozenge 0.0055 0.0035 0.0035
Brugia malayi Protein kinase domain containing protein 0.004 0.0016 0.0027
Schistosoma mansoni growth hormone secretagogue receptor 0.1053 0.1311 0.1311
Onchocerca volvulus 0.1053 0.1311 0.7915
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1053 0.1311 0.1311
Loa Loa (eye worm) TK/INSR protein kinase 0.0049 0.0027 0.0072
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0047 0.0212
Trichomonas vaginalis adenosine deaminase, putative 0.0085 0.0074 0.0333
Onchocerca volvulus Adenosine deaminase homolog 0.0085 0.0074 0.0444
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0034 0.0008 0.0008
Echinococcus multilocularis cyclin B3 1 0.0104 0.0098 0.0098
Echinococcus granulosus Tubulin beta 2C chain 0.0093 0.0083 0.0083
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0204 0.0226 0.1023
Echinococcus multilocularis cyclins 0.0104 0.0098 0.0098
Echinococcus multilocularis Tubulin beta 2C chain 0.0093 0.0083 0.0083
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0004 0.0004
Toxoplasma gondii aspartyl protease ASP1 0.1755 0.2208 1
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Schistosoma mansoni tyrosine kinase 0.0082 0.0069 0.0069
Entamoeba histolytica adenosine deaminase, putative 0.0085 0.0074 0.1039
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1053 0.1311 0.1311
Plasmodium falciparum plasmepsin IX 0.0596 0.0726 0.3288
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0087 0.0075 0.4511
Loa Loa (eye worm) neuropeptide F receptor 0.1053 0.1311 0.3445
Onchocerca volvulus 0.0255 0.0291 0.1758
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1053 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Echinococcus multilocularis heat shock protein 0.0172 0.0184 0.0184
Plasmodium falciparum protein kinase 5 0.005 0.0029 0.013
Brugia malayi Pre-SET motif family protein 0.0035 0.0009 0.0015
Echinococcus granulosus tissue type plasminogen activator 0.004 0.0015 0.0015
Brugia malayi Dopamine receptor protein 2 0.1053 0.1311 0.2169
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.003 0.003
Brugia malayi Cyclin, N-terminal domain containing protein 0.0104 0.0098 0.0161
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1053 0.1311 0.1311
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.0333 0.1507
Trichomonas vaginalis cyclins, putative 0.0222 0.0249 0.1126
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0052 0.0731
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Schistosoma mansoni neuropeptide F-like receptor 0.1053 0.1311 0.1311
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0053 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0432 0.0518 0.136
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0222 0.0249 0.3511
Echinococcus multilocularis 0.0048 0.0025 0.0025
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1053 0.1311 0.1311
Schistosoma mansoni protein kinase 0.0518 0.0627 0.0627
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0014 0.0014
Echinococcus granulosus neuropeptides capa receptor 0.1053 0.1311 0.1311
Brugia malayi Serotonin receptor 0.1053 0.1311 0.2169
Brugia malayi beta-lactamase family protein 0.0039 0.0014 0.0023
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.1755 0.2208 0.2208
Brugia malayi Protein set-1 0.0067 0.005 0.0082
Plasmodium vivax protein kinase Crk2 0.005 0.0029 0.013
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0084 0.0222
Brugia malayi endoprotease bli-4 precursor 0.0143 0.0148 0.0244
Echinococcus multilocularis insulin receptor 0.0049 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Echinococcus multilocularis orexin receptor type 2 0.1053 0.1311 0.1311
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1053 0.1311 0.2169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0052 0.0591
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0206 0.0934
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1053 0.1311 0.1311
Schistosoma mansoni ap endonuclease 0.0039 0.0014 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0047 0.0213
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Schistosoma mansoni tyrosine kinase 0.0049 0.0027 0.0027
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0285 0.0329 0.0328
Schistosoma mansoni neuropeptide f receptor 76f 0.1053 0.1311 0.1311
Trichomonas vaginalis cyclin B, putative 0.0222 0.0249 0.1126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0052 0.0591
Schistosoma mansoni cathepsin D (A01 family) 0.5033 0.6401 0.6401
Trichomonas vaginalis cyclins, putative 0.0222 0.0249 0.1126
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0008 0.0008
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0084 0.1192
Echinococcus granulosus dro:myosuppressin receptor 0.1053 0.1311 0.1311
Echinococcus granulosus neuropeptide receptor A26 0.1053 0.1311 0.1311
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1053 0.1311 0.1311
Echinococcus granulosus leucine aminopeptidase protein 0.0113 0.0109 0.0109
Echinococcus granulosus serine:threonine protein kinase 0.0253 0.0288 0.0288
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1053 0.1311 0.1311
Schistosoma mansoni tyrosine kinase 0.0083 0.007 0.007
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0085 0.0074 0.0193
Echinococcus granulosus cpg binding protein 0.0032 0.0006 0.0006
Echinococcus multilocularis Tubulin beta 2C chain 0.0093 0.0083 0.0083
Onchocerca volvulus 0.1053 0.1311 0.7915
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0143 0.0148 0.0388
Plasmodium falciparum endoplasmin, putative 0.0081 0.0069 0.0311
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0014 0.0036
Trichomonas vaginalis cyclin B, putative 0.0222 0.0249 0.1126
Echinococcus granulosus rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Loa Loa (eye worm) glutamate receptor 1 0.0034 0.0008 0.002
Echinococcus granulosus insulin receptor 0.0049 0.0027 0.0027
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0008 0.0008
Echinococcus multilocularis neuropeptide Y receptor 0.1053 0.1311 0.1311
Plasmodium falciparum heat shock protein 90, putative 0.0054 0.0034 0.0154
Schistosoma mansoni hypothetical protein 0.0897 0.1111 0.1111
Echinococcus multilocularis cyclins 0.0104 0.0098 0.0098
Plasmodium vivax heat shock protein 90, putative 0.0054 0.0034 0.0154
Trichomonas vaginalis heat shock protein, putative 0.0145 0.015 0.0679
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Entamoeba histolytica heat shock protein 90, putative 0.0172 0.0184 0.2605
Onchocerca volvulus 0.1053 0.1311 0.7915
Plasmodium falciparum cyclin 0.0104 0.0098 0.0442
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0034 0.0008 0.0008
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1053 0.1311 0.2169
Toxoplasma gondii aspartyl protease 0.0432 0.0518 0.2344
Trypanosoma brucei polo-like protein kinase 0.0094 0.0084 0.0963
Schistosoma mansoni serine-type protease inhibitor 0.5521 0.7024 0.7024
Brugia malayi G-protein coupled receptor 0.1053 0.1311 0.2169
Entamoeba histolytica cyclin family protein 0.0104 0.0098 0.1378
Trypanosoma brucei Aminopeptidase M1, putative 0.0581 0.0708 0.8077
Schistosoma mansoni thyroid hormone receptor 0.0153 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0057 0.0038 0.01
Schistosoma mansoni hypothetical protein 0.0415 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Echinococcus multilocularis neuropeptide receptor A26 0.1053 0.1311 0.1311
Entamoeba histolytica tubulin family protein 0.0093 0.0083 0.1169
Trypanosoma brucei heat shock protein 90, putative 0.0172 0.0184 0.2104
Loa Loa (eye worm) hypothetical protein 0.0118 0.0115 0.0303
Leishmania major cathepsin L-like protease 0.0068 0.0052 0.0731
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0454 0.0545 0.1431
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0008 0.0035
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0047 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0052 0.0591
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0047 0.0212
Leishmania major heat shock protein, putative 0.0054 0.0034 0.0481
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Plasmodium vivax plasmepsin IV, putative 0.1755 0.2208 1
Giardia lamblia G2/mitotic-specific cyclin B 0.0222 0.0249 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0432 0.0518 0.0856
Schistosoma mansoni tyrosine kinase 0.0154 0.0161 0.0161
Echinococcus granulosus biogenic amine 5HT receptor 0.1053 0.1311 0.1311
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0084 0.1192
Entamoeba histolytica heat shock protein 90, putative 0.0172 0.0184 0.2605
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Brugia malayi Protein kinase domain containing protein 0.005 0.0029 0.0047
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0008 0.0035
Trypanosoma cruzi heat shock protein 85, putative 0.0172 0.0184 0.2605
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0014 0.0023
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0029 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0015 0.0212
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1053 0.1311 0.1311
Schistosoma mansoni neuropeptide receptor 0.1053 0.1311 0.1311
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0014 0.0194
Brugia malayi Glutamate receptor 2 precursor 0.0034 0.0008 0.0013
Brugia malayi Cyclin, N-terminal domain containing protein 0.0222 0.0249 0.0411
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0053 0.0032 0.0032
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0034 0.0155
Loa Loa (eye worm) proprotein convertase 2 0.0034 0.0008 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0084 0.0084
Echinococcus granulosus heat shock protein 90 0.0172 0.0184 0.0184
Brugia malayi GnHR receptor homolog 0.4754 0.6044 1
Echinococcus granulosus neuropeptide receptor 0.1053 0.1311 0.1311
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0581 0.0708 0.0708
Echinococcus granulosus leukotriene A 4 hydrolase 0.0204 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0581 0.0708 1
Trypanosoma brucei mitotic cyclin 6 0.0222 0.0249 0.2836
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0014 0.0194
Schistosoma mansoni amine GPCR 0.1053 0.1311 0.1311
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1053 0.1311 0.1311
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0047 0.0212
Brugia malayi ORL1-like opioid receptor 0.1053 0.1311 0.2169
Brugia malayi cell division control protein 2 homolog 0.005 0.0029 0.0047
Giardia lamblia High cysteine membrane protein Group 2 0.0053 0.0033 0.0801
Plasmodium vivax SET domain protein, putative 0.0035 0.0009 0.004
Loa Loa (eye worm) hypothetical protein 0.0057 0.0038 0.01
Onchocerca volvulus 0.1053 0.1311 0.7915
Brugia malayi G-protein coupled receptor 0.1053 0.1311 0.2169
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0047 0.0123
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0009 0.0009
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0204 0.0226 0.0226
Giardia lamblia Grp94/Hsp90 0.0145 0.015 0.5796
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0113 0.0109 0.0307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1053 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.0252 0.0662
Schistosoma mansoni cpg binding protein 0.0032 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Onchocerca volvulus 0.0039 0.0014 0.0083
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0204 0.0226 0.0226
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Echinococcus multilocularis nmda type glutamate receptor 0.012 0.0118 0.0118
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0087 0.0076 0.0076
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.059 0.0719 0.0719
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0518 0.0627 0.0627
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1053 0.1311 0.1311
Loa Loa (eye worm) glutaminase 2 0.0564 0.0685 0.1801
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0052 0.0591
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0042 0.0192
Schistosoma mansoni glutamate receptor NMDA 0.0285 0.0329 0.0328
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0039
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Onchocerca volvulus Glucosylceramidase homolog 0.0189 0.0206 0.1245
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0014 0.0157
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0036
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1053 0.1311 0.1311
Echinococcus multilocularis Protein lozenge 0.0055 0.0035 0.0035
Brugia malayi Adenosine/AMP deaminase family protein 0.0085 0.0074 0.0122
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0581 0.0708 1
Schistosoma mansoni aminopeptidase A (M01 family) 0.0204 0.0226 0.0226
Schistosoma mansoni memapsin-2 (A01 family) 0.0432 0.0518 0.0517
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0014 0.0000022169
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1053 0.1311 0.2169
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0047 0.0123
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.005 0.0029 0.0405
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0143 0.0148 0.0148
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0047 0.0212
Schistosoma mansoni amine GPCR 0.1053 0.1311 0.1311
Echinococcus granulosus 7TM GPCR rhodopsin 0.1053 0.1311 0.1311
Brugia malayi TATA binding protein associated factor 0.0204 0.0226 0.0374
Loa Loa (eye worm) hypothetical protein 0.0064 0.0047 0.0123
Entamoeba histolytica adenosine deaminase, putative 0.0085 0.0074 0.1039
Echinococcus multilocularis rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0145 0.015 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0432 0.0518 0.0517
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0036
Toxoplasma gondii beta-1 tubulin, putative 0.0093 0.0083 0.0375
Giardia lamblia Hypothetical protein 0.0104 0.0098 0.3571
Loa Loa (eye worm) heat shock protein 90 0.0172 0.0184 0.0485
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0008 0.0008
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Trypanosoma brucei aminopeptidase, putative 0.0204 0.0226 0.2577
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0113 0.0109 0.1538
Trichomonas vaginalis set domain proteins, putative 0.0255 0.0291 0.1319
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0204 0.0226 0.1023
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.003 0.003
Echinococcus multilocularis beta tubulin 0.0093 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1053 0.1311 0.1311
Schistosoma mansoni ap endonuclease 0.0039 0.0014 0.0014
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0204 0.0226 0.1023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0052 0.0591
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Trypanosoma brucei heat shock protein, putative 0.0172 0.0184 0.2104
Trypanosoma brucei RNA helicase, putative 0.0713 0.0876 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0014 0.0036
Leishmania major adenine aminohydrolase 0.0085 0.0074 0.1039
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Brugia malayi Glutamate receptor 1 precursor 0.0034 0.0008 0.0013
Echinococcus granulosus adenosine deaminase 0.0085 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Echinococcus granulosus rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Loa Loa (eye worm) TK/ROR protein kinase 0.0043 0.002 0.0053
Schistosoma mansoni tubulin subunit beta 0.0093 0.0083 0.0083
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0014 0.0023
Trichomonas vaginalis tubulin beta chain, putative 0.0093 0.0083 0.0375
Onchocerca volvulus 0.1323 0.1656 1
Schistosoma mansoni neuropeptide F-like receptor 0.1053 0.1311 0.1311
Loa Loa (eye worm) peptidase family M1 containing protein 0.0557 0.0677 0.178
Onchocerca volvulus 0.044 0.0527 0.318
Brugia malayi CXXC zinc finger family protein 0.003 0.0003 0.0005
Trypanosoma brucei Aminopeptidase M1, putative 0.0581 0.0708 0.8077
Schistosoma mansoni amine GPCR 0.1053 0.1311 0.1311
Schistosoma mansoni neuropeptide receptor 0.1053 0.1311 0.1311
Schistosoma mansoni myosin xvIII 0.1053 0.1311 0.1311
Schistosoma mansoni adenosine deaminase 0.0085 0.0074 0.0074
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0581 0.0708 0.0708
Brugia malayi Peptidase family M1 containing protein 0.0934 0.1159 0.1918
Echinococcus granulosus neuropeptide Y receptor 0.1053 0.1311 0.1311
Echinococcus multilocularis Furin 1 0.0034 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0052 0.0591
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0029 0.0029
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0029 0.0405
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0029 0.0075
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.1755 0.2208 1
Echinococcus granulosus cyclins 0.0104 0.0098 0.0098
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0054 0.0034 0.0034
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0581 0.0708 0.0708
Brugia malayi Cam kinase protein 1 0.0064 0.0047 0.0078
Echinococcus granulosus tm gpcr rhodopsin 0.1053 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Echinococcus granulosus serotonin receptor 0.1053 0.1311 0.1311
Echinococcus multilocularis g protein coupled receptor 0.1053 0.1311 0.1311
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.129 0.1614 0.4242
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0029 0.0075
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.0279 0.0858
Trypanosoma brucei beta tubulin 0.0093 0.0083 0.0945
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Echinococcus granulosus cyclin B 0.0222 0.0249 0.0249
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Echinococcus granulosus peptide allatostatin:somatostatin 0.1053 0.1311 0.1311
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Trypanosoma brucei beta tubulin 0.0093 0.0083 0.0945
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Schistosoma mansoni hypothetical protein 0.0415 0.0495 0.0495
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0204 0.0226 0.319
Brugia malayi neuroendocrine convertase 1 precursor 0.009 0.008 0.0132
Brugia malayi hypothetical protein 0.1053 0.1311 0.2169
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0014 0.0063
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0008 0.0035
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0051 0.003 0.003
Schistosoma mansoni heat shock protein 0.0172 0.0184 0.0184
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0034 0.0008 0.0008
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0014 0.0063
Echinococcus granulosus beta tubulin 0.0093 0.0083 0.0083
Schistosoma mansoni serine-type protease inhibitor 0.5521 0.7024 0.7024
Trypanosoma brucei heat shock protein, putative 0.0172 0.0184 0.2104
Loa Loa (eye worm) aspartyl protease 6 0.0432 0.0518 0.136
Echinococcus granulosus tubulin beta 4A class IVa 0.0093 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.0333 0.1507
Trypanosoma brucei Heat shock protein 83, putative 0.0172 0.0184 0.2104
Trypanosoma brucei cdc2-related kinase 3 0.005 0.0029 0.0327
Plasmodium vivax heat shock protein 86, putative 0.0172 0.0184 0.0835
Echinococcus granulosus alpha 1A adrenergic receptor 0.1053 0.1311 0.1311
Onchocerca volvulus 0.1053 0.1311 0.7915
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0014 0.0194
Plasmodium falciparum M17 leucyl aminopeptidase 0.0113 0.0109 0.0493
Schistosoma mansoni ATP-binding cassette transporter 0.0034 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.044 0.0527 0.1384
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.005 0.0029 0.0405
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0432 0.0518 0.0517
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0047 0.0535
Echinococcus multilocularis rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Echinococcus multilocularis leucine aminopeptidase protein 0.0113 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0087 0.0075 0.0198
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0034 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.004 0.0015 0.0212
Echinococcus multilocularis GPCR, family 2 0.0415 0.0495 0.0495
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.005 0.0029 0.0029
Echinococcus granulosus heat shock protein 0.0172 0.0184 0.0184
Trypanosoma cruzi heat shock protein 85, putative 0.0145 0.015 0.2116
Brugia malayi G protein-coupled receptor F59B2.13 0.1053 0.1311 0.2169
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Toxoplasma gondii Hsp90 domain-containing protein 0.0054 0.0034 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0014 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0026 0.0116
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0145 0.015 0.044
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1053 0.1311 0.1311
Schistosoma mansoni heat shock protein 0.0054 0.0034 0.0034
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0014 0.0062
Loa Loa (eye worm) glutaminase 0.0564 0.0685 0.1801
Loa Loa (eye worm) hypothetical protein 0.0085 0.0074 0.0193
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Echinococcus multilocularis serotonin receptor 0.1053 0.1311 0.1311
Brugia malayi Angiotensin-converting enzyme family protein 0.129 0.1614 0.267
Loa Loa (eye worm) hypothetical protein 0.0204 0.0226 0.0594
Echinococcus multilocularis epidermal growth factor receptor 0.0083 0.007 0.007
Echinococcus multilocularis neuroendocrine convertase 2 0.009 0.008 0.008
Loa Loa (eye worm) TYRA-2 protein 0.1053 0.1311 0.3445
Mycobacterium ulcerans heat shock protein 90 0.0145 0.015 0.044
Entamoeba histolytica protein kinase, putative 0.0064 0.0047 0.0663
Trypanosoma brucei beta tubulin 0.0093 0.0083 0.0945
Loa Loa (eye worm) endoplasmin 0.0172 0.0184 0.0485
Onchocerca volvulus 0.004 0.0015 0.0091
Schistosoma mansoni protein kinase 0.0518 0.0627 0.0627
Brugia malayi Melatonin receptor type 1A 0.1053 0.1311 0.2169
Toxoplasma gondii heat shock protein 90, putative 0.0172 0.0184 0.0835
Plasmodium vivax aspartyl protease, putative 0.0596 0.0726 0.3288
Toxoplasma gondii kringle domain-containing protein 0.004 0.0015 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.0333 0.1507
Brugia malayi hypothetical protein 0.1053 0.1311 0.2169
Echinococcus multilocularis cyclins 0.0104 0.0098 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Loa Loa (eye worm) BEN-1 protein 0.0093 0.0083 0.0218
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Leishmania major protein kinase, putative 0.0064 0.0047 0.0663
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0084 0.0084
Schistosoma mansoni biogenic amine (5HT) receptor 0.1053 0.1311 0.1311
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0029 0.0405
Leishmania major cyclin 0.0222 0.0249 0.3511
Echinococcus granulosus tm gpcr rhodopsin 0.1053 0.1311 0.1311
Schistosoma mansoni cpg binding protein 0.003 0.0003 0.0003
Plasmodium falciparum plasmepsin IV 0.1755 0.2208 1
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Trichomonas vaginalis cyclins, putative 0.0222 0.0249 0.1126
Trypanosoma brucei heat shock protein 84, putative 0.0054 0.0034 0.0389
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0014 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0026 0.0116
Loa Loa (eye worm) tubulin beta-4 chain 0.0093 0.0083 0.0218
Onchocerca volvulus 0.0222 0.0249 0.15
Echinococcus granulosus tm gpcr rhodopsin 0.1053 0.1311 0.1311
Echinococcus granulosus beta tubulin 0.0093 0.0083 0.0083
Echinococcus multilocularis rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Echinococcus multilocularis thyroid hormone receptor alpha 0.0153 0.016 0.016
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0033 0.0467
Echinococcus multilocularis neuropeptides capa receptor 0.1053 0.1311 0.1311
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0047 0.0212
Echinococcus multilocularis dnaJ subfamily B 0.0433 0.0518 0.0518
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0581 0.0708 1
Echinococcus multilocularis tubulin beta 1 chain 0.0093 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.0333 0.1507
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1053 0.1311 0.1311
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0084 0.1192
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0047 0.0047
Echinococcus multilocularis cyclins 0.0104 0.0098 0.0098
Echinococcus granulosus g-protein coupled receptor 0.1053 0.1311 0.1311
Echinococcus multilocularis aminopeptidase N 0.0934 0.1159 0.1159
Trypanosoma cruzi heat shock protein 90, putative 0.0172 0.0184 0.2605
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1053 0.1311 0.1311
Trichomonas vaginalis cyclins, putative 0.0222 0.0249 0.1126
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1053 0.1311 0.3445
Echinococcus granulosus cyclins 0.0104 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Giardia lamblia Heat shock protein HSP 90-alpha 0.0145 0.015 0.5796
Schistosoma mansoni biogenic amine receptor 0.1053 0.1311 0.1311
Echinococcus granulosus nmda type glutamate receptor 0.012 0.0118 0.0118
Echinococcus multilocularis cyclin dependent kinase 0.005 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.003 0.003
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0029 0.0405
Onchocerca volvulus 0.1053 0.1311 0.7915
Brugia malayi Cyclin, N-terminal domain containing protein 0.0222 0.0249 0.0411
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1053 0.1311 0.1311
Echinococcus multilocularis Tubulin beta 2C chain 0.0093 0.0083 0.0083
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0084 0.1192
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Trypanosoma brucei beta tubulin 0.0093 0.0083 0.0945
Loa Loa (eye worm) hypothetical protein 0.0897 0.1111 0.2921
Onchocerca volvulus 0.1053 0.1311 0.7915
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Echinococcus granulosus endoplasmin 0.0145 0.015 0.015
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0047 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0029 0.0029
Treponema pallidum adenosine deaminase 0.0085 0.0074 0.4393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0052 0.0591
Echinococcus granulosus glutamate NMDA receptor subunit 0.0285 0.0329 0.0328
Echinococcus multilocularis adenosine deaminase 0.0085 0.0074 0.0074
Mycobacterium ulcerans epoxide hydrolase EphA 0.016 0.017 0.0504
Loa Loa (eye worm) hypothetical protein 0.3003 0.3805 1
Schistosoma mansoni opsin-like receptor 0.1053 0.1311 0.1311
Trypanosoma cruzi beta tubulin, putative 0.0093 0.0083 0.1169
Schistosoma mansoni endoplasmin 0.0172 0.0184 0.0184
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0014 0.0063
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0052 0.0731
Brugia malayi AKH receptor 0.1053 0.1311 0.2169
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0014 0.0014
Echinococcus granulosus myosin light chain kinase smooth muscle 0.0253 0.0288 0.0288
Plasmodium vivax aspartyl protease, putative 0.0596 0.0726 0.3288
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0085 0.0074 0.0333
Echinococcus granulosus epidermal growth factor receptor 0.0154 0.0161 0.0161
Trichomonas vaginalis tubulin epsilon chain, putative 0.0093 0.0083 0.0375
Plasmodium falciparum plasmepsin V 0.0432 0.0518 0.2344
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0014 0.0000022169
Plasmodium vivax endoplasmin, putative 0.0172 0.0184 0.0835
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1053 0.1311 0.1311
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.0333 0.1507
Trypanosoma cruzi aminopeptidase, putative 0.0581 0.0708 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0047 0.0212
Echinococcus multilocularis endoplasmin 0.0145 0.015 0.015
Schistosoma mansoni hypothetical protein 0.004 0.0015 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0432 0.0518 0.0517
Schistosoma mansoni opsin-like receptor 0.1053 0.1311 0.1311
Trypanosoma brucei heat shock protein, putative 0.0172 0.0184 0.2104
Toxoplasma gondii leucyl aminopeptidase LAP 0.0113 0.0109 0.0493
Trypanosoma cruzi CYC2-like cyclin, putative 0.0222 0.0249 0.3511
Trichomonas vaginalis tubulin epsilon chain, putative 0.0093 0.0083 0.0375
Echinococcus multilocularis neuropeptide receptor 0.7848 1 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0581 0.0708 0.0708
Trichomonas vaginalis tubulin alpha chain, putative 0.0093 0.0083 0.0375
Echinococcus granulosus tachykinin peptides receptor 99D 0.1053 0.1311 0.1311
Schistosoma mansoni hypothetical protein 0.0713 0.0876 0.0876
Giardia lamblia Beta tubulin 0.0093 0.0083 0.2941
Echinococcus multilocularis g protein coupled receptor 0.1053 0.1311 0.1311
Loa Loa (eye worm) TK/EGFR protein kinase 0.0154 0.0161 0.0424
Schistosoma mansoni neuropeptide receptor 0.7848 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.1053 0.1311 0.3445
Trichomonas vaginalis glucosylceramidase, putative 0.0288 0.0333 0.1507
Echinococcus granulosus furin 0.0143 0.0148 0.0148
Loa Loa (eye worm) aminopeptidase N 0.0581 0.0708 0.1861
Schistosoma mansoni hypothetical protein 0.0034 0.0008 0.0008
Echinococcus multilocularis neuropeptide s receptor 0.1053 0.1311 0.1311
Plasmodium vivax adenosine deaminase, putative 0.0085 0.0074 0.0333
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0014 0.0194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1053 0.1311 0.1311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1053 0.1311 0.1311
Trichomonas vaginalis cyclin D, putative 0.0104 0.0098 0.0442
Plasmodium falciparum plasmepsin X 0.0596 0.0726 0.3288
Echinococcus multilocularis cyclins 0.0104 0.0098 0.0098
Leishmania major hypothetical protein, conserved 0.0039 0.0014 0.0194
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.003 0.003
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0047 0.0047
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0518 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0222 0.0249 0.0653
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0084 0.0383
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1053 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.0415 0.0495 0.1302
Brugia malayi hypothetical protein 0.1053 0.1311 0.2169
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Mycobacterium ulcerans aminopeptidase N PepN 0.0204 0.0226 0.0686
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0206 0.0934
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.1755 0.2208 0.2208
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0084 0.0383
Echinococcus multilocularis heat shock protein 90 0.0172 0.0184 0.0184
Echinococcus multilocularis NMDA receptor 0.0034 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.1323 0.1656 0.4353
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0204 0.0226 0.0226
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0014 0.0157
Onchocerca volvulus 0.0934 0.1159 0.6999
Loa Loa (eye worm) melatonin receptor type 1A 0.1053 0.1311 0.3445
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0003 0.0009
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1053 0.1311 0.3445
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0206 0.0934
Plasmodium falciparum heat shock protein 90 0.0172 0.0184 0.0835
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1053 0.1311 0.3445
Echinococcus multilocularis serine:threonine protein kinase 0.0253 0.0288 0.0288
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0113 0.0109 0.0307
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1053 0.1311 0.1311
Schistosoma mansoni tubulin subunit beta 0.0093 0.0083 0.0083
Brugia malayi neuropeptide F receptor 0.1053 0.1311 0.2169
Loa Loa (eye worm) hypothetical protein 0.0056 0.0036 0.0096
Schistosoma mansoni biogenic amine receptor 0.1053 0.1311 0.1311
Echinococcus multilocularis cyclin dependent kinase 5 0.005 0.0029 0.0029
Entamoeba histolytica cyclin, putative 0.0222 0.0249 0.3511
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1053 0.1311 0.1311
Echinococcus granulosus g protein coupled receptor 0.1053 0.1311 0.1311
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0219 0.0993
Echinococcus granulosus hypothetical protein 0.1053 0.1311 0.1311
Loa Loa (eye worm) BEN-1 protein 0.0093 0.0083 0.0218
Brugia malayi Serotonin receptor 0.1053 0.1311 0.2169
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0047 0.0212
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0204 0.0226 0.319
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.2458 0.3107 1
Schistosoma mansoni tyrosine kinase 0.0049 0.0027 0.0027
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0052 0.0731
Loa Loa (eye worm) tubulin beta chain 0.0093 0.0083 0.0218
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.2106 0.2658 0.2658
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Leishmania major cathepsin L-like protease 0.0068 0.0052 0.0731
Schistosoma mansoni cathepsin D (A01 family) 0.5033 0.6401 0.6401
Brugia malayi putative neuropeptide receptor NPR1 0.1053 0.1311 0.2169
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Brugia malayi neuropeptide F receptor 0.1053 0.1311 0.2169
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0014 0.0194
Echinococcus granulosus glutamate receptor 2 0.0051 0.003 0.003
Entamoeba histolytica cyclin, putative 0.0104 0.0098 0.1378
Echinococcus granulosus rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Brugia malayi Latrophilin receptor protein 2 0.0415 0.0495 0.082
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1053 0.1311 0.1311
Onchocerca volvulus 0.1053 0.1311 0.7915
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0581 0.0708 0.0708
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Schistosoma mansoni cpg binding protein 0.0032 0.0006 0.0006
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0581 0.0708 0.0708
Plasmodium vivax plasmepsin V, putative 0.0432 0.0518 0.2344
Entamoeba histolytica cyclin family protein 0.0104 0.0098 0.1378
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0036
Mycobacterium ulcerans aminopeptidase N PepN 0.0581 0.0708 0.2244
Brugia malayi Endoplasmin precursor 0.0172 0.0184 0.0305
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1053 0.1311 0.1311
Schistosoma mansoni hypothetical protein 0.0135 0.0137 0.0137
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0044 0.0624
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1053 0.1311 0.1311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1053 0.1311 0.1311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.0076 0.0344
Giardia lamblia Kinase, CMGC CDK 0.005 0.0029 0.0637
Echinococcus multilocularis neuropeptide FF receptor 2 0.1053 0.1311 0.1311
Leishmania major cathepsin L-like protease 0.0068 0.0052 0.0731
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1053 0.1311 0.2169
Brugia malayi Tachykinin-like peptides receptor 99D 0.1053 0.1311 0.2169
Echinococcus multilocularis myosin light chain kinase, smooth muscle 0.0253 0.0288 0.0288
Loa Loa (eye worm) G-protein coupled receptor 0.1053 0.1311 0.3445
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0083 0.007 0.007
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0104 0.0098 0.0098
Echinococcus multilocularis dro:myosuppressin receptor 0.1053 0.1311 0.1311
Schistosoma mansoni hypothetical protein 0.1053 0.1311 0.1311
Brugia malayi hypothetical protein 0.0581 0.0708 0.1171
Loa Loa (eye worm) hypothetical protein 0.0057 0.0038 0.01
Trichomonas vaginalis cyclin D, putative 0.0104 0.0098 0.0442
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0145 0.015 0.044
Schistosoma mansoni glutamate receptor NMDA 0.0051 0.003 0.003
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0067 0.005 0.005
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0113 0.0109 0.1538
Loa Loa (eye worm) latrophilin receptor protein 2 0.0415 0.0495 0.1302
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.016 0.017 0.0504
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Trypanosoma brucei heat shock protein, putative 0.0172 0.0184 0.2104
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0454 0.0545 0.0901
Brugia malayi Tubulin beta-1 chain 0.0093 0.0083 0.0137
Brugia malayi beta-tubulin, identical 0.0093 0.0083 0.0137
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0014 0.0014
Plasmodium falciparum cysteine repeat modular protein 1 0.004 0.0015 0.0068
Schistosoma mansoni adenoreceptor 0.1053 0.1311 0.1311
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0204 0.0226 0.1023
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0432 0.0518 0.0517
Toxoplasma gondii aminopeptidase N, putative 0.0204 0.0226 0.1023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.2106 0.2658 0.2658
Trichomonas vaginalis cyclin B, putative 0.0104 0.0098 0.0442
Echinococcus multilocularis cyclin b3 0.0104 0.0098 0.0098
Echinococcus granulosus fmrfamide receptor 0.1053 0.1311 0.1311
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0014 0.0063
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1053 0.1311 0.7915
Onchocerca volvulus 0.1053 0.1311 0.7915
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0034 0.0008 0.0008
Trichomonas vaginalis cyclin B3, putative 0.0104 0.0098 0.0442
Trichomonas vaginalis cyclins, putative 0.0104 0.0098 0.0442
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Brugia malayi hypothetical protein 0.1053 0.1311 0.2169
Echinococcus granulosus aminopeptidase N 0.0934 0.1159 0.1159
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1053 0.1311 0.2169
Schistosoma mansoni opsin-like receptor 0.1053 0.1311 0.1311
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0029 0.0405
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0067 0.005 0.005
Schistosoma mansoni hypothetical protein 0.1053 0.1311 0.1311
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0047 0.0212
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0581 0.0708 0.3206
Chlamydia trachomatis cytosol aminopeptidase 0.0113 0.0109 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0008 0.0035
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1053 0.1311 0.1311
Echinococcus granulosus tubulin subunit beta 0.0093 0.0083 0.0083
Entamoeba histolytica tubulin family protein 0.0093 0.0083 0.1169
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0135 0.0137 0.0137
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0135 0.0137 0.0137
Entamoeba histolytica protein kinase, putative 0.0064 0.0047 0.0663
Giardia lamblia Heat shock protein HSP 90-alpha 0.0172 0.0184 0.7269
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0581 0.0708 0.3206
Brugia malayi hypothetical protein 0.0432 0.0518 0.0856
Onchocerca volvulus 0.0432 0.0518 0.3125
Echinococcus multilocularis somatostatin receptor 0.1053 0.1311 0.1311
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0084 0.0383
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0054 0.0034 0.0034
Echinococcus granulosus g protein coupled receptor 0.1053 0.1311 0.1311
Echinococcus granulosus cyclins 0.0104 0.0098 0.0098
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0581 0.0708 0.0708
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1053 0.1311 0.1311
Echinococcus granulosus Tubulin beta 2C chain 0.0093 0.0083 0.0083
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0034 0.0008 0.0008
Schistosoma mansoni protein kinase 0.0518 0.0627 0.0627
Trichomonas vaginalis esterase, putative 0.0039 0.0014 0.0063
Loa Loa (eye worm) runx1 0.0055 0.0035 0.0092
Trichomonas vaginalis cyclins, putative 0.0143 0.0148 0.0668
Onchocerca volvulus 0.1053 0.1311 0.7915
Echinococcus multilocularis epidermal growth factor receptor 0.0154 0.0161 0.0161
Schistosoma mansoni tubulin subunit beta 0.0093 0.0083 0.0083
Trichomonas vaginalis tubulin gamma chain, putative 0.0093 0.0083 0.0375
Toxoplasma gondii aspartyl protease ASP3 0.0596 0.0726 0.3288
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0087 0.0076 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0014 0.0014
Brugia malayi hypothetical protein 0.1053 0.1311 0.2169
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.003 0.003
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.003 0.003
Echinococcus granulosus sex peptide receptor 0.1053 0.1311 0.1311
Echinococcus granulosus rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0204 0.0226 0.1023
Onchocerca volvulus 0.1053 0.1311 0.7915
Loa Loa (eye worm) cyclin domain-containing protein 0.0104 0.0098 0.0256
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Schistosoma mansoni kinase 0.0049 0.0027 0.0027
Mycobacterium ulcerans leucyl aminopeptidase 0.0113 0.0109 0.0307
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0047 0.0047
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1323 0.1656 0.1656
Onchocerca volvulus 0.0035 0.0009 0.0053
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1053 0.1311 0.1311
Brugia malayi aspartic protease BmAsp-1, identical 0.0432 0.0518 0.0856
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0145 0.015 0.2116
Brugia malayi hypothetical protein 0.1053 0.1311 0.2169
Trypanosoma cruzi cyclin, putative 0.0222 0.0249 0.3511
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0029 0.0405
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0054 0.0034 0.0206
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Trypanosoma brucei heat shock protein, putative 0.0172 0.0184 0.2104
Loa Loa (eye worm) hypothetical protein 0.0067 0.005 0.0131
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0204 0.0226 0.0594
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0014 0.0062
Brugia malayi sulfakinin receptor protein 0.1053 0.1311 0.2169
Trypanosoma cruzi cyclin 6, putative 0.0222 0.0249 0.3511
Treponema pallidum heat shock protein 90 0.0145 0.015 1
Onchocerca volvulus 0.0432 0.0518 0.3125
Schistosoma mansoni tyrosine kinase 0.0082 0.0069 0.0069
Echinococcus multilocularis cyclins 0.0104 0.0098 0.0098
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0051 0.0051
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0581 0.0708 0.0708
Echinococcus multilocularis serotonin receptor 0.1053 0.1311 0.1311
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0113 0.0109 0.699
Brugia malayi Eukaryotic aspartyl protease family protein 0.0432 0.0518 0.0856
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1053 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.044 0.0527 0.1384
Echinococcus granulosus somatostatin receptor 0.1053 0.1311 0.1311
Schistosoma mansoni glutaminase 0.0564 0.0685 0.0685
Trypanosoma cruzi Heat shock protein 83, putative 0.0172 0.0184 0.2605
Schistosoma mansoni tyrosine kinase 0.0082 0.0069 0.0069
Schistosoma mansoni adenosine deaminase-related 0.0085 0.0074 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0052 0.0591
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1053 0.1311 0.1311
Schistosoma mansoni hypothetical protein 0.1053 0.1311 0.1311
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0037 0.0012 0.0012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0009 0.004
Plasmodium vivax aspartyl proteinase, putative 0.0432 0.0518 0.2344
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1053 0.1311 0.1311
Echinococcus multilocularis fmrfamide receptor 0.1053 0.1311 0.1311
Onchocerca volvulus 0.1053 0.1311 0.7915
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0084 0.0383
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0014 0.0062
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0204 0.0226 0.319
Loa Loa (eye worm) hypothetical protein 0.073 0.0898 0.236
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.2458 0.3107 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0084 0.051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1312 0.1642 0.4316
Plasmodium falciparum tubulin beta chain 0.0093 0.0083 0.0375
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0581 0.0708 0.0708
Toxoplasma gondii heat shock protein 75, putative 0.0054 0.0034 0.0154
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0415 0.0495 0.082
Plasmodium vivax aspartyl proteinase, putative 0.1755 0.2208 1
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Echinococcus multilocularis rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Onchocerca volvulus 0.1053 0.1311 0.7915
Echinococcus granulosus neuropeptide FF receptor 2 0.1053 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Schistosoma mansoni thyroid hormone receptor 0.0153 0.016 0.016
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Echinococcus granulosus rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Trypanosoma cruzi heat shock protein, putative 0.0054 0.0034 0.0481
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0085 0.0074 0.0193
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0034 0.0008 0.0008
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0014 0.0014
Onchocerca volvulus 0.003 0.0003 0.002
Schistosoma mansoni furin-1 (S08 family) 0.0062 0.0044 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0206 0.0934
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0204 0.0226 0.319
Trichomonas vaginalis heat shock protein, putative 0.0081 0.0069 0.0311
Plasmodium falciparum plasmepsin I 0.1755 0.2208 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0093 0.0083 0.0083
Echinococcus granulosus Tubulin beta 2C chain 0.0093 0.0083 0.0083
Trypanosoma cruzi heat shock protein 90, putative 0.0145 0.015 0.2116
Echinococcus granulosus neuropeptide s receptor 0.1053 0.1311 0.1311
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0377 0.0447 0.6308
Giardia lamblia Cyclin A 0.0104 0.0098 0.3571
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0014 0.0063
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Plasmodium falciparum plasmepsin II 0.1755 0.2208 1
Onchocerca volvulus 0.1053 0.1311 0.7915
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0052 0.0591
Echinococcus multilocularis beta tubulin 0.0093 0.0083 0.0083
Echinococcus multilocularis cyclin B 0.0222 0.0249 0.0249
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0047 0.0212
Brugia malayi heat shock protein 90 0.0172 0.0184 0.0305
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0581 0.0708 0.8077
Plasmodium falciparum heat shock protein 90, putative 0.0054 0.0034 0.0154
Schistosoma mansoni tubulin subunit beta 0.0093 0.0083 0.0083
Brugia malayi hypothetical protein 0.1053 0.1311 0.2169
Brugia malayi Peptidase family M1 containing protein 0.0581 0.0708 0.1171
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Echinococcus multilocularis tissue type plasminogen activator 0.004 0.0015 0.0015
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0204 0.0226 0.319
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0029 0.013
Brugia malayi Peptidase family M1 containing protein 0.0204 0.0226 0.0374
Loa Loa (eye worm) hypothetical protein 0.0222 0.0249 0.0653
Brugia malayi G protein-coupled receptor 0.1053 0.1311 0.2169
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0432 0.0518 0.0517
Echinococcus granulosus g protein coupled receptor 0.1053 0.1311 0.1311
Echinococcus granulosus neuropeptides capa receptor 0.1053 0.1311 0.1311
Echinococcus granulosus allatostatin A receptor 0.1323 0.1656 0.1656
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1053 0.1311 0.1311
Echinococcus multilocularis g protein coupled receptor 0.1053 0.1311 0.1311
Onchocerca volvulus 0.1053 0.1311 0.7915
Onchocerca volvulus 0.1053 0.1311 0.7915
Brugia malayi hypothetical protein 0.044 0.0527 0.0871
Onchocerca volvulus 0.0039 0.0014 0.0083
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0029 0.0029
Plasmodium falciparum adenosine deaminase 0.0085 0.0074 0.0333
Loa Loa (eye worm) aspartic protease BmAsp-2 0.1755 0.2208 0.5804
Echinococcus granulosus 7tm_1 domain containing protein 0.1053 0.1311 0.1311
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0084 0.0383
Echinococcus multilocularis heat shock protein 90 0.0145 0.015 0.015
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0204 0.0226 0.319
Loa Loa (eye worm) hypothetical protein 0.0047 0.0025 0.0066
Schistosoma mansoni cyclins 0.0104 0.0098 0.0098
Trichomonas vaginalis cyclin B, putative 0.0222 0.0249 0.1126
Echinococcus multilocularis neuropeptide Y receptor 0.1053 0.1311 0.1311
Echinococcus granulosus neuroendocrine convertase 2 0.009 0.008 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0008 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0029 0.013
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1053 0.1311 0.1311
Trichomonas vaginalis adenosine deaminase, putative 0.0085 0.0074 0.0333
Trypanosoma cruzi cyclin, putative 0.0222 0.0249 0.3511
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0377 0.0447 0.0446
Loa Loa (eye worm) tubulin beta-2A chain 0.0093 0.0083 0.0218
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1053 0.1311 0.3445
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0113 0.0109 0.1242
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0581 0.0708 0.0708
Brugia malayi celfurPC protein 0.0116 0.0112 0.0186
Loa Loa (eye worm) glutamate receptor 2 0.0034 0.0008 0.002
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0377 0.0447 0.0446
Echinococcus multilocularis rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.0076 0.0344
Brugia malayi beta-lactamase family protein 0.0039 0.0014 0.0023
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0432 0.0518 0.0517
Echinococcus multilocularis allatostatin A receptor 0.1323 0.1656 0.1656
Trichomonas vaginalis glutaminase, putative 0.0564 0.0685 0.3104
Schistosoma mansoni neuropeptide receptor 0.1053 0.1311 0.1311
Echinococcus multilocularis neuropeptides capa receptor 0.1053 0.1311 0.1311
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0085 0.0074 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0206 0.0934
Loa Loa (eye worm) beta-tubulin 0.0093 0.0083 0.0218
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0029 0.0405
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0084 0.014
Echinococcus granulosus neuropeptide Y receptor 0.1053 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.0204 0.0226 0.0594
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0047 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.1053 0.1311 0.1311
Trichomonas vaginalis tubulin, putative 0.0093 0.0083 0.0375
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0204 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.1053 0.1311 0.3445
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0415 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.1755 0.2208 0.5804
Giardia lamblia Beta tubulin 0.0093 0.0083 0.2941
Onchocerca volvulus Neuropeptide F receptor homolog 0.1053 0.1311 0.7915
Toxoplasma gondii beta tubulin 0.0093 0.0083 0.0375
Toxoplasma gondii aminopeptidase n, putative 0.0204 0.0226 0.1023
Brugia malayi Kringle domain containing protein 0.004 0.0015 0.0025
Echinococcus granulosus Furin 1 0.0034 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0098 0.0442
Leishmania major heat shock protein 83-1 0.0172 0.0184 0.2605
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0113 0.0109 0.1538
Echinococcus granulosus cyclin B3 1 0.0104 0.0098 0.0098
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0093 0.0083 0.0083
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1053 0.1311 0.1311
Brugia malayi hypothetical protein 0.1053 0.1311 0.2169
Brugia malayi Pre-SET motif family protein 0.0225 0.0252 0.0417
Toxoplasma gondii beta-tubulin, putative 0.0093 0.0083 0.0375
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.3003 0.3805 0.6295
Schistosoma mansoni heat shock protein 0.0172 0.0184 0.0184
Plasmodium falciparum plasmepsin III 0.0432 0.0518 0.2344
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Brugia malayi putative neuropeptide receptor 0.1053 0.1311 0.2169
Echinococcus multilocularis tubulin subunit beta 0.0093 0.0083 0.0083
Brugia malayi Pepsin A precursor 0.0432 0.0518 0.0856
Loa Loa (eye worm) endoprotease bli-4 0.0143 0.0148 0.0388
Plasmodium vivax heat shock protein, putative 0.0054 0.0034 0.0154
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0051 0.003 0.003
Echinococcus granulosus Tubulin beta 2C chain 0.0093 0.0083 0.0083
Loa Loa (eye worm) heat shock protein 75 0.0054 0.0034 0.009
Echinococcus granulosus orexin receptor type 2 0.1053 0.1311 0.1311
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0084 0.0383
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0052 0.0731
Leishmania major beta tubulin 0.0093 0.0083 0.1169
Echinococcus granulosus cyclins 0.0104 0.0098 0.0098
Trichomonas vaginalis heat shock protein, putative 0.0145 0.015 0.0679
Echinococcus granulosus G protein coupled receptor 139 0.1053 0.1311 0.1311
Trypanosoma cruzi heat shock protein 85, putative 0.0172 0.0184 0.2605
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0206 0.0934
Loa Loa (eye worm) hypothetical protein 0.0204 0.0226 0.0594
Plasmodium falciparum plasmepsin VI 0.1755 0.2208 1
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.0219 0.0993
Trypanosoma brucei heat shock protein, putative 0.0172 0.0184 0.2104
Echinococcus granulosus GPCR family 2 0.0415 0.0495 0.0495
Mycobacterium ulcerans glutaminase 0.0564 0.0685 0.2171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0009 0.0009

Activities

Activity type Activity value Assay description Source Reference
Efficacy (binding) = 56.64 Efficacy of the compound towards human Tachykinin receptor 2 was determined ChEMBL. 10425111
Efficacy (binding) = 56.6399999999999 Efficacy of the compound towards human Tachykinin receptor 2 was determined ChEMBL. 10425111
KA (ADMET) = 941 nm KA value of the compound was determined ChEMBL. 10425111
Ki (binding) > 2000 nM The compound was tested for competition binding with [3H]-NKA against the CHO cells from cloned human Tachykinin receptor 2 ChEMBL. 10425111
Ki (binding) > 2000 nM The compound was tested for competition binding with [3H]-NKA against the CHO cells from cloned human Tachykinin receptor 2 ChEMBL. 10425111

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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