Detailed information for compound 1700998

Basic information

Technical information
  • TDR Targets ID: 1700998
  • Name: 2-[[(1-amino-2-sulfosulfanylethylidene)amino] methyl]-7,7-dimethylbicyclo[3.1.1]heptane
  • MW: 306.445 | Formula: C12H22N2O3S2
  • H donors: 2 H acceptors: 3 LogP: 1.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=NCC1CCC2CC1C2(C)C)CSS(=O)(=O)O
  • InChi: 1S/C12H22N2O3S2/c1-12(2)9-4-3-8(10(12)5-9)6-14-11(13)7-18-19(15,16)17/h8-10H,3-7H2,1-2H3,(H2,13,14)(H,15,16,17)
  • InChiKey: VOOABHIKMGRJFC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[(1-amino-2-sulfosulfanyl-ethylidene)amino]methyl]-6,6-dimethyl-norpinane
  • 2-[[[1-amino-2-(sulfothio)ethylidene]amino]methyl]-6,6-dimethylnorpinane
  • 2-[[[1-amino-2-(sulfothio)ethylidene]amino]methyl]-6,6-dimethyl-norpinane
  • 2-[[(1-amino-2-sulfosulfanyl-ethylidene)amino]methyl]-7,7-dimethyl-bicyclo[3.1.1]heptane
  • 90379-42-3
  • NSC 194308
  • S-(2-(((6,6-Dimethylbicyclo(3.1.1)hept-2-yl)methyl)amino)-2-iminoethyl) hydrogen thiosulfate
  • AIDS-127862
  • AIDS127862
  • NSC194308
  • S-(2-(((6,6-Dimethylbicyclo[3.1.1]hept-2-yl)methyl)amino)-2-iminoethyl) hydrogen thiosulfate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens perilipin 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens hepatocyte nuclear factor 4, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Transcription factor HNF-4 homolog, putative Get druggable targets OG5_131038 All targets in OG5_131038
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) Get druggable targets OG5_131038 All targets in OG5_131038
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Hepatocyte nuclear factor 4-beta, putative Get druggable targets OG5_131038 All targets in OG5_131038
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha Get druggable targets OG5_131038 All targets in OG5_131038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 Get druggable targets OG5_131038 All targets in OG5_131038
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Nuclear hormone receptor family member nhr-49 Get druggable targets OG5_131038 All targets in OG5_131038
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus hepatocyte nuclear factor 4 alpha Get druggable targets OG5_131038 All targets in OG5_131038
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0413 0.0425
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0396 0.0408
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.172 0.1517
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.7716 1
Trypanosoma brucei polo-like protein kinase 0.0114 0.7716 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0413 0.0447
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0413 0.0447
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0926 0.4007
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0396 0.0408
Schistosoma mansoni coup transcription factor 0.0012 0.0413 0.0447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0413 0.0413
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.7716 0.7954
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0517 0.0532
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0413 0.0425
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0413 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0413 0.0425
Loa Loa (eye worm) hypothetical protein 0.0012 0.0413 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0413 0.0413
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.7716 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0142 0.9701 0.9701
Brugia malayi nuclear hormone receptor 0.0012 0.0413 0.0425
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.7716 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0413 0.0425
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.7716 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0413 0.0425
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.172 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.7716 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.7716 0.7954
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0413 0.0425
Schistosoma mansoni kinase 0.0058 0.3694 0.3999
Loa Loa (eye worm) hypothetical protein 0.0012 0.0413 0.0413
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0413 0.0425
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0413 0.0425
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.7716 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0142 0.9701 1
Loa Loa (eye worm) RecQ helicase 0.0029 0.1616 0.1616
Loa Loa (eye worm) hypothetical protein 0.0012 0.0413 0.0413
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0413 0.0447
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0413 0.0425
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0413 0.0447
Loa Loa (eye worm) hypothetical protein 0.0012 0.0413 0.0413
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.7716 0.7954
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.7716 0.8352
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.7716 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0413 0.0425
Loa Loa (eye worm) hypothetical protein 0.0012 0.0413 0.0413
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.1616 0.1666
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0396 0.0000000029503
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0413 0.0425
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.172 1
Brugia malayi hypothetical protein 0.002 0.0947 0.0976
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0396 0.0408
Loa Loa (eye worm) hypothetical protein 0.0012 0.0396 0.0396
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0413 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0413 0.0425
Loa Loa (eye worm) hypothetical protein 0.0012 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0012 0.0413 0.0413
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.3586 0.4157
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0413 0.0425
Giardia lamblia Kinase, PLK 0.0114 0.7716 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0135 0.9239 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.7716 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.172 0.1517
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.7716 1
Leishmania major hypothetical protein, conserved 0.003 0.172 0.1517
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.1616 0.137
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0413 0.0425
Brugia malayi nuclear receptor NHR-88 0.0012 0.0413 0.0425
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0413 0.0413
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0396 0.0408
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0413 0.0425
Schistosoma mansoni hypothetical protein 0.0014 0.0517 0.0559
Schistosoma mansoni DNA helicase recq5 0.0012 0.0396 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0413 0.0425
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.7716 0.7716
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0413 0.0447
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.172 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.7716 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0142 0.9701 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.1179 0.1276
Loa Loa (eye worm) hypothetical protein 0.003 0.172 0.172
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0413 0.0425
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0413 0.0425
Schistosoma mansoni DNA helicase recq1 0.0012 0.0396 0.0428
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0413 0.0447
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.1616 0.137
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0413 0.0413
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.3586 0.4157
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0413 0.0447
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0413 0.0425
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0413 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0413 0.0425
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0413 0.0425
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.1364 0.7309
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0413 0.0425
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.7716 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0396 0.0396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0413 0.0413
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.172 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0413 0.0425
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0413 0.0425
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0142 0.9701 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0413 0.0413
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0413 0.0447
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0413 0.0447
Brugia malayi hypothetical protein 0.003 0.172 0.1773
Brugia malayi steroid hormone receptor 0.0012 0.0413 0.0425
Echinococcus granulosus bloom syndrome protein 0.0029 0.1616 0.1666
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0517 0.0532
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0413 0.0425
Brugia malayi ecdysteroid receptor 0.0012 0.0413 0.0425
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0413 0.0425
Loa Loa (eye worm) hypothetical protein 0.0012 0.0413 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0413 0.0425
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0396 0.0408
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0413 0.0425
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.7716 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0413 0.0447
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0413 0.0425
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0396 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0413 0.0425
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.172 0.1517
Echinococcus multilocularis bloom syndrome protein 0.0029 0.1616 0.1666
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0413 0.0447

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 4.29 uM PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 4.448 uM PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 65.27 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 155.058 uM PubChem BioAssay. Absorbance-based biochemical high throughput dose response assay to identify inhibitors of Methionine sulfoxide reductase A (MsrA). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.7444 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.