Detailed information for compound 1701105

Basic information

Technical information
  • TDR Targets ID: 1701105
  • Name: N-(2,4-dimethylphenyl)-N-[2-oxo-2-(propan-2-y lamino)ethyl]-N'-pyridin-2-ylbutanediamide
  • MW: 396.483 | Formula: C22H28N4O3
  • H donors: 2 H acceptors: 4 LogP: 2.16 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)CN(c1ccc(cc1C)C)C(=O)CCC(=O)Nc1ccccn1)C
  • InChi: 1S/C22H28N4O3/c1-15(2)24-21(28)14-26(18-9-8-16(3)13-17(18)4)22(29)11-10-20(27)25-19-7-5-6-12-23-19/h5-9,12-13,15H,10-11,14H2,1-4H3,(H,24,28)(H,23,25,27)
  • InChiKey: KNUYVNCKNBACCB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dimethylphenyl)-N-[2-(isopropylamino)-2-oxo-ethyl]-N'-(2-pyridyl)butanediamide
  • N-(2,4-dimethylphenyl)-N-[2-(isopropylamino)-2-oxoethyl]-N'-(2-pyridyl)butanediamide
  • N-(2,4-dimethylphenyl)-N-[2-(isopropylamino)-2-keto-ethyl]-N'-(2-pyridyl)succinamide
  • N-(2,4-dimethylphenyl)-N-[2-oxo-2-(propan-2-ylamino)ethyl]-N'-pyridin-2-yl-butanediamide
  • ASN 05391194
  • ZINC04848199

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein coupled receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0022 0.0163 0.016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0022 0.0163 0.016
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0114 0.1283 0.8014
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.0004 0.0001
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0242 0.5778
Onchocerca volvulus 0.0009 0.0004 0.0006
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0004 0.0001
Plasmodium falciparum flap endonuclease 1 0.0029 0.0242 0.5778
Echinococcus granulosus family S9 non peptidase ue S09 family 0.014 0.1601 0.1598
Brugia malayi hypothetical protein 0.0029 0.025 0.0247
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0417 1
Brugia malayi hypothetical protein 0.0009 0.0004 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.007 0.0746 0.0743
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0004 0.0001
Echinococcus granulosus Dipeptidyl peptidase 9 0.0038 0.036 0.0357
Echinococcus multilocularis dnaJ subfamily B 0.0553 0.663 0.6629
Schistosoma mansoni BC026374 protein (S09 family) 0.014 0.1601 0.1598
Schistosoma mansoni neuropeptide receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0476 0.0473
Brugia malayi hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni amine GPCR 0.0009 0.0004 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Mycobacterium tuberculosis Probable hydrolase 0.0033 0.0292 0.1184
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0349 0.4148 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.014 0.1601 0.6547
Echinococcus multilocularis beta LACTamase domain containing family member 0.0033 0.0292 0.0289
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.0004 0.0001
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0242 0.1893
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0465 0.2906
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0622 0.0619
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0033 0.0292 0.1184
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0004 0.0001
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.0004 0.0001
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0004 0.0001
Onchocerca volvulus 0.0009 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0009 0.0004 0.0001
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0113 0.1268 0.1265
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.014 0.1601 0.1598
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0004 0.0001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0004 0.0001
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.1839 0.1836
Echinococcus multilocularis sex peptide receptor 0.0009 0.0004 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0004 0.0001
Onchocerca volvulus 0.0009 0.0004 0.0006
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0004 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0566 0.0563
Schistosoma mansoni histamine h1 receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Onchocerca volvulus 0.0009 0.0004 0.0006
Onchocerca volvulus 0.014 0.1601 1
Toxoplasma gondii ABC1 family protein 0.0033 0.0292 0.2284
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0292 0.1824
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1349 0.1347
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0349 0.4148 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.014 0.1601 0.1598
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.0004 0.0001
Onchocerca volvulus 0.014 0.1601 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0004 0.0001
Mycobacterium ulcerans lipase LipD 0.0033 0.0292 0.1356
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0113 0.1268 0.1265
Echinococcus multilocularis carboxylesterase 5A 0.083 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0004 0.0001
Brugia malayi ORL1-like opioid receptor 0.0009 0.0004 0.0001
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0004 0.0001
Schistosoma mansoni neuropeptide receptor 0.0009 0.0004 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Brugia malayi hypothetical protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.014 0.1601 0.6547
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0033 0.0292 0.1184
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0004 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0566 0.0563
Echinococcus granulosus survival motor neuron protein 1 0.0226 0.2644 0.2642
Onchocerca volvulus 0.0009 0.0004 0.0006
Schistosoma mansoni biogenic amine receptor 0.0009 0.0004 0.0001
Echinococcus granulosus somatostatin receptor 0.0009 0.0004 0.0001
Brugia malayi beta-lactamase 0.0033 0.0292 0.0289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0004 0.0001
Echinococcus granulosus neuropeptide receptor 0.0009 0.0004 0.0001
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.0289
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0004 0.0001
Brugia malayi hypothetical protein 0.0009 0.0004 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0292 0.0697
Echinococcus multilocularis acetylcholinesterase 0.083 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0004 0.0001
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0004 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Echinococcus granulosus para nitrobenzyl esterase 0.014 0.1601 0.1598
Brugia malayi prolyl oligopeptidase family protein 0.0038 0.036 0.0357
Mycobacterium tuberculosis Carboxylesterase LipT 0.014 0.1601 0.6547
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0004 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0004 0.0001
Echinococcus granulosus neuroligin 0.014 0.1601 0.1598
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Brugia malayi mbt repeat family protein 0.0053 0.0533 0.053
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0114 0.1283 0.1281
Brugia malayi hypothetical protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0622 0.1493
Entamoeba histolytica hypothetical protein 0.0033 0.0292 0.6966
Loa Loa (eye worm) pigment dispersing factor receptor c 0.007 0.0746 0.0743
Entamoeba histolytica hypothetical protein 0.0033 0.0292 0.6966
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0566 0.0563
Schistosoma mansoni cpg binding protein 0.0041 0.0393 0.039
Brugia malayi Dopamine receptor 0.0009 0.0004 0.0001
Brugia malayi larval opioid receptor 0.0009 0.0004 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0077 0.0837 0.659
Trichomonas vaginalis spcc417.12 protein, putative 0.014 0.1601 1
Leishmania major hypothetical protein, conserved 0.0033 0.0292 0.0697
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.083 1 1
Loa Loa (eye worm) hypothetical protein 0.014 0.1601 0.1598
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0292 0.0289
Schistosoma mansoni hypothetical protein 0.0553 0.663 0.6629
Loa Loa (eye worm) acetylcholinesterase 1 0.083 1 1
Brugia malayi Dopamine receptor protein 1 0.0009 0.0004 0.0001
Onchocerca volvulus 0.014 0.1601 1
Echinococcus granulosus cpg binding protein 0.0041 0.0393 0.039
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Brugia malayi hypothetical protein 0.0226 0.2644 0.2642
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0417 1
Echinococcus granulosus acetylcholinesterase 0.083 1 1
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0038 0.036 0.0862
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0038 0.036 0.0862
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.1268 0.1265
Schistosoma mansoni hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0004 0.0001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0004 0.0001
Mycobacterium leprae Probable lipase LipE 0.0033 0.0292 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0004 0.0001
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0114 0.1283 0.1281
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0039 0.0036
Echinococcus multilocularis BC026374 protein (S09 family) 0.014 0.1601 0.1598
Brugia malayi MH2 domain containing protein 0.012 0.1349 0.1347
Onchocerca volvulus 0.0053 0.0533 0.3319
Brugia malayi sulfakinin receptor protein 0.0009 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0033 0.0292 0.0289
Brugia malayi Carboxylesterase family protein 0.014 0.1601 0.1598
Schistosoma mansoni opsin-like receptor 0.0009 0.0004 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0004 0.0001
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0533 0.053
Brugia malayi AKH receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) MBCTL1 0.006 0.0622 0.0619
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0038 0.036 0.0357
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.1839 0.1836
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.006 0.0622 0.0619
Schistosoma mansoni hypothetical protein 0.0022 0.0163 0.016
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.2417 0.2414
Schistosoma mansoni amine GPCR 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Mycobacterium tuberculosis Probable esterase LipL 0.0033 0.0292 0.1184
Toxoplasma gondii Alpha-galactosidase 0.0016 0.0087 0.0667
Entamoeba histolytica hypothetical protein 0.0033 0.0292 0.6966
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0242 0.0578
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis acetylcholinesterase 0.083 1 1
Toxoplasma gondii hypothetical protein 0.0056 0.0579 0.4553
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0292 0.6254
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Brugia malayi Flap endonuclease-1 0.0029 0.0242 0.024
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0242 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0491 0.1178
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0292 0.0697
Onchocerca volvulus 0.0009 0.0004 0.0006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.025 0.0247
Onchocerca volvulus 0.0009 0.0004 0.0006
Brugia malayi Serotonin receptor 0.0009 0.0004 0.0001
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0009 0.0003 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1906 0.4593
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0622 0.0619
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0566 0.0563
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.001 0.0007
Brugia malayi hypothetical protein 0.0009 0.0004 0.0001
Toxoplasma gondii melibiase subfamily protein 0.0113 0.1268 1
Schistosoma mansoni amine GPCR 0.0009 0.0004 0.0001
Trichomonas vaginalis esterase, putative 0.0033 0.0292 0.1824
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0533 0.3319
Echinococcus granulosus dnaJ subfamily B 0.0553 0.663 0.6629
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0075 0.081 0.0807
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.0004 0.0001
Schistosoma mansoni cpg binding protein 0.0041 0.0393 0.039
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0465 0.3653
Loa Loa (eye worm) hypothetical protein 0.014 0.1601 0.1598
Mycobacterium tuberculosis Probable lipase LipD 0.0033 0.0292 0.1184
Brugia malayi Serotonin receptor 0.0009 0.0004 0.0001
Echinococcus granulosus carboxylesterase 5A 0.083 1 1
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0039 0.0036
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.014 0.1601 0.1598
Echinococcus granulosus allatostatin A receptor 0.0009 0.0004 0.0001
Brugia malayi beta-lactamase family protein 0.0033 0.0292 0.0289
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0292 0.1824
Schistosoma mansoni neuropeptide receptor 0.0009 0.0004 0.0001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0454 0.0451
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) prolyl oligopeptidase 0.0114 0.1283 0.1281
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0292 0.0289
Onchocerca volvulus 0.014 0.1601 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0566 0.0563
Brugia malayi Latrophilin receptor protein 2 0.0022 0.0163 0.016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.0289
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0209 0.2443 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0004 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0022 0.0163 0.016
Schistosoma mansoni opsin-like receptor 0.0009 0.0004 0.0001
Echinococcus granulosus g protein coupled receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0004 0.0001
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0566 0.0563
Echinococcus multilocularis serotonin receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0004 0.0001
Onchocerca volvulus 0.0009 0.0004 0.0006
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0113 0.1268 0.1265
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0242 0.5182
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.0289
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0004 0.0001
Brugia malayi neuropeptide F receptor 0.0009 0.0004 0.0001
Brugia malayi Carboxylesterase family protein 0.014 0.1601 0.1598
Brugia malayi hypothetical protein 0.014 0.1601 0.1598
Schistosoma mansoni hypothetical protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0163 0.016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0082 0.0896 0.0893
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0114 0.1283 0.1281
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0022 0.0163 0.016
Mycobacterium ulcerans beta-lactamase 0.0033 0.0292 0.1356
Brugia malayi prolyl oligopeptidase family protein 0.0114 0.1283 0.1281
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0465 0.2906
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0292 0.0289
Brugia malayi RE15519p 0.0009 0.0004 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0004 0.0001
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.1268 0.1265
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus granulosus fmrfamide receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.014 0.1601 0.1598
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0004 0.0001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.014 0.1601 0.1598
Schistosoma mansoni neuropeptide receptor 0.0009 0.0004 0.0001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.1906 0.4593
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0292 0.0697
Mycobacterium ulcerans esterase/lipase LipP 0.0033 0.0292 0.1356
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0087 0.0084
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0038 0.036 0.0862
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Brugia malayi Carboxylesterase family protein 0.014 0.1601 0.1598
Echinococcus granulosus hypothetical protein 0.0009 0.0004 0.0001
Onchocerca volvulus 0.0033 0.0292 0.1809
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0004 0.0001
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0465 0.3653
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.007 0.0746 0.0743
Brugia malayi neuropeptide F receptor 0.0009 0.0004 0.0001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0033 0.0292 0.1184
Echinococcus multilocularis survival motor neuron protein 1 0.0226 0.2644 0.2642
Onchocerca volvulus 0.0009 0.0004 0.0006
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.014 0.1601 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0004 0.0001
Onchocerca volvulus 0.0009 0.0004 0.0006
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0533 0.053
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0022 0.0163 0.016
Loa Loa (eye worm) hypothetical protein 0.014 0.1601 0.1598
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.0289
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.0004 0.0001
Onchocerca volvulus 0.0009 0.0004 0.0006
Echinococcus granulosus neuropeptide s receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis cpg binding protein 0.0041 0.0393 0.039
Mycobacterium tuberculosis Conserved protein 0.0033 0.0292 0.1184
Onchocerca volvulus 0.014 0.1601 1
Brugia malayi Carboxylesterase family protein 0.083 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0004 0.0001
Brugia malayi mbt repeat family protein 0.0053 0.0533 0.053
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0533 0.053
Onchocerca volvulus 0.0033 0.0292 0.1809
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0004 0.0001
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis serotonin receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0292 0.1824
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.081 0.0807
Onchocerca volvulus 0.0009 0.0004 0.0006
Brugia malayi beta-lactamase family protein 0.0033 0.0292 0.0289
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0566 0.0563
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0622 0.0619
Brugia malayi follicle stimulating hormone receptor 0.0009 0.0004 0.0001
Brugia malayi hypothetical protein 0.0033 0.0292 0.0289
Loa Loa (eye worm) hypothetical protein 0.014 0.1601 0.1598
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0039 0.0036
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0417 1
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0004 0.0001
Onchocerca volvulus Neuropeptide F receptor homolog 0.0009 0.0004 0.0006
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0242 0.5778
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0033 0.0292 0.1356
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0491 0.1178
Mycobacterium tuberculosis Conserved protein 0.0033 0.0292 0.1184
Schistosoma mansoni amine GPCR 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.014 0.1601 0.1598
Entamoeba histolytica hypothetical protein 0.0033 0.0292 0.6966
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0004 0.0001
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0004 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.1784 0.1782
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0533 0.053
Brugia malayi hypothetical protein 0.0009 0.0004 0.0001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0578 0.6935 0.6934
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.007 0.0746 0.0743
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Brugia malayi G protein-coupled receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.0289
Echinococcus multilocularis somatostatin receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis GPCR, family 2 0.0022 0.0163 0.016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.001 0.0007
Schistosoma mansoni hypothetical protein 0.0046 0.0454 0.0451
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0226 0.2644 0.2642
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0292 0.1824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0004 0.0001
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0048 0.0476 0.0473
Brugia malayi putative neuropeptide receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) beta-lactamase 0.0033 0.0292 0.0289
Onchocerca volvulus 0.0009 0.0004 0.0006
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0004 0.0001
Schistosoma mansoni survival motor neuron protein 0.0046 0.0454 0.0451
Onchocerca volvulus 0.0046 0.0454 0.2823
Echinococcus granulosus acetylcholinesterase 0.083 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.1268 0.1265
Brugia malayi Carboxylesterase family protein 0.014 0.1601 0.1598
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.001 0.0007
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0037 0.0034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0292 0.0289
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0242 0.1515
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0004 0.0001
Schistosoma mansoni acetylcholinesterase 0.014 0.1601 0.1598
Onchocerca volvulus 0.0033 0.0292 0.1809
Echinococcus multilocularis para nitrobenzyl esterase 0.014 0.1601 0.1598
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.081 0.0807
Brugia malayi G-protein coupled receptor 0.0009 0.0004 0.0001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.014 0.1601 0.1598
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus granulosus orexin receptor type 2 0.0009 0.0004 0.0001
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0004 0.0001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0004 0.0001
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0004 0.0001
Schistosoma mansoni flap endonuclease-1 0.0026 0.0209 0.0206
Brugia malayi Melibiase family protein 0.0075 0.081 0.0807
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0004 0.0001
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0533 0.053
Schistosoma mansoni hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0022 0.0163 0.016
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0465 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0004 0.0001
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0004 0.0001
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.1268 0.1265
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0622 0.0619
Mycobacterium tuberculosis Conserved protein 0.0033 0.0292 0.1184
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0491 0.1178
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0292 0.0289
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0009 0.0004 0.0006
Schistosoma mansoni adenoreceptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.2417 0.2414
Mycobacterium ulcerans hypothetical protein 0.0033 0.0292 0.1356
Schistosoma mansoni opsin-like receptor 0.0009 0.0004 0.0001
Brugia malayi G-protein coupled receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0292 0.0289
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0533 0.053
Schistosoma mansoni myosin xvIII 0.0009 0.0004 0.0001
Mycobacterium ulcerans carboxylesterase, LipT 0.014 0.1601 0.7497
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0038 0.036 0.0357
Brugia malayi Melatonin receptor type 1A 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0292 1
Onchocerca volvulus 0.0039 0.0366 0.2271
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0033 0.0292 0.0289
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0566 0.0563
Loa Loa (eye worm) hypothetical protein 0.0053 0.0533 0.053
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.2134 0.8733
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0004 0.0001
Onchocerca volvulus 0.0009 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.001 0.0007
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1349 0.1347
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0004 0.0001
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0242 0.0578
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0622 0.0619
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1906 0.4593
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0566 0.0563
Loa Loa (eye worm) acetyltransferase 0.016 0.1839 0.1836
Echinococcus granulosus BC026374 protein S09 family 0.014 0.1601 0.1598
Onchocerca volvulus 0.0009 0.0004 0.0006
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0004 0.0001
Echinococcus granulosus neuropeptide receptor 0.0009 0.0004 0.0001
Onchocerca volvulus 0.0009 0.0004 0.0006
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0038 0.036 0.0862
Echinococcus granulosus serotonin receptor 0.0009 0.0004 0.0001
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0004 0.0001
Brugia malayi Dopamine receptor protein 2 0.0009 0.0004 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0022 0.0163 0.016
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0033 0.0292 0.0289
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Onchocerca volvulus 0.0009 0.0004 0.0006
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0004 0.0001
Leishmania major mitochondrial DNA polymerase beta 0.0349 0.4148 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0004 0.0001
Echinococcus granulosus GPCR family 2 0.0022 0.0163 0.016
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0533 0.053
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0004 0.0001
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0622 0.0619
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0004 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0292 0.1824
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0349 0.4148 1
Mycobacterium tuberculosis Probable lipase LipE 0.0033 0.0292 0.1184
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0004 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Brugia malayi GnHR receptor homolog 0.0009 0.0004 0.0001
Brugia malayi hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0533 0.053
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus granulosus sex peptide receptor 0.0009 0.0004 0.0001
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0039 0.0366 0.0363
Schistosoma mansoni amine GPCR 0.0009 0.0004 0.0001
Echinococcus granulosus beta LACTamase domain containing family member 0.0033 0.0292 0.0289
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0242 0.0578
Schistosoma mansoni biogenic amine receptor 0.0009 0.0004 0.0001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0465 0.0462
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0004 0.0001
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0004 0.0001
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.032 0.3786 0.3784
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0004 0.0001
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0003 0.0019
Schistosoma mansoni gliotactin 0.014 0.1601 0.1598
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) carboxylesterase 0.083 1 1
Brugia malayi hypothetical protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) carboxylesterase 0.014 0.1601 0.1598
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0004 0.0001
Echinococcus granulosus flap endonuclease 1 0.0029 0.0242 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Loa Loa (eye worm) carboxylesterase 0.014 0.1601 0.1598
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.0004 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.001 0.0007
Brugia malayi CXXC zinc finger family protein 0.0039 0.0366 0.0363
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0004 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0004 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.014 0.1601 0.1598
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.0004 0.0001
Mycobacterium ulcerans hypothetical protein 0.0184 0.2134 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0004 0.0001
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.0004 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0022 0.0163 0.016
Brugia malayi hypothetical protein 0.0009 0.0004 0.0001
Echinococcus granulosus g protein coupled receptor 0.0009 0.0004 0.0001
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0075 0.081 0.506
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0004 0.0001
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0004 0.0001
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.1839 0.1836
Schistosoma mansoni biogenic amine receptor 0.0009 0.0004 0.0001
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0242 0.024
Echinococcus multilocularis neuroligin 0.014 0.1601 0.1598
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0491 0.1178
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0038 0.036 0.0862
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0004 0.0001
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0004 0.0001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0022 0.0163 0.016
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0004 0.0001
Schistosoma mansoni cpg binding protein 0.0039 0.0366 0.0363
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.0004 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0004 0.0001
Brugia malayi latrophilin 2 splice variant baaae 0.0048 0.0476 0.0473
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0038 0.036 0.2824

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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