Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | perilipin 1 | Starlite/ChEMBL | No references |
Homo sapiens | hepatocyte nuclear factor 4, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma japonicum | Hepatocyte nuclear factor 4-beta, putative | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma japonicum | Transcription factor HNF-4 homolog, putative | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0456 | 0.1904 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.2395 | 0.2032 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0456 | 0.1904 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2395 | 0.2032 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0456 | 0.1904 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.1382 | 0.4775 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.2395 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0456 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0456 | 0.1904 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0142 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.2395 | 0.2144 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.2395 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.2395 | 0.2032 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.2395 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0135 | 0.9499 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0456 | 0.1904 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0456 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.2395 | 0.2032 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0456 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.1382 | 0.4775 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0456 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0456 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0456 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0456 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0456 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0456 | 0.1904 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0456 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0142 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.1382 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0456 | 0.1904 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0456 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0456 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0456 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0456 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0456 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0456 | 0.1904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 1.839 uM | PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 1.895 uM | PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.