Detailed information for compound 170153

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 676.806 | Formula: C33H36N6O6S2
  • H donors: 3 H acceptors: 6 LogP: 5.35 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1ccc(cc1)S(=O)(=O)[O-].Cc1ccc(cc1)S(=O)(=O)O.NC(=N)N/N=C/c1ccc(cc1)/C=C/c1cn2c([n+]1C)cccc2C
  • InChi: 1S/C19H21N6.2C7H8O3S/c1-14-4-3-5-18-24(2)17(13-25(14)18)11-10-15-6-8-16(9-7-15)12-22-23-19(20)21;2*1-6-2-4-7(5-3-6)11(8,9)10/h3-13H,1-2H3,(H4,20,21,23);2*2-5H,1H3,(H,8,9,10)/q+1;;/p-1/b11-10+,22-12+;;
  • InChiKey: ZOORVNMTHMFMPM-QEWMUQJDSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0039 0.0441 0.0388
Echinococcus multilocularis microtubule associated protein 2 0.0569 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0053 0.07 0.6064
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0039 0.0441 0.0962
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0441 0.145
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0454 0.3936
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0078 0.1154 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0279 0.477 0.4741
Brugia malayi latrophilin 2 splice variant baaae 0.0027 0.0227 0.0428
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0055 0.0473
Brugia malayi hypothetical protein 0.0062 0.0859 0.2004
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0017 0.0055 0.011
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0055 0.0115
Loa Loa (eye worm) thioredoxin reductase 0.0165 0.2718 0.5698
Mycobacterium ulcerans hypothetical protein 0.0017 0.0055 0.0102
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0037 0.0403 0.035
Echinococcus granulosus Ankyrin 0.0024 0.0175 0.0121
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0289
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0039 0.0441 0.0388
Plasmodium falciparum phosphodiesterase delta, putative 0.0039 0.0441 0.1622
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0055 0.0473
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0017 0.0055 0.011
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0039 0.0441 0.145
Mycobacterium tuberculosis Probable oxidoreductase 0.0041 0.0489 0.0982
Echinococcus granulosus thioredoxin glutathione reductase 0.0166 0.2741 0.2701
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0041 0.0489 0.163
Brugia malayi amine oxidase, flavin-containing family protein 0.0022 0.0138 0.0207
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0039 0.0441 0.145
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0279 0.477 0.4741
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0041 0.0489 0.1081
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0078 0.1154 0.1106
Mycobacterium ulcerans dehydrogenase 0.0017 0.0055 0.0102
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0078 0.1154 1
Schistosoma mansoni amine oxidase 0.0022 0.0138 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0138 0.0506
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0078 0.1154 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0039 0.0441 0.0388
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0041 0.0489 0.0982
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0064 0.0895 0.3156
Plasmodium vivax phosphodiesterase gamma, putative 0.0039 0.0441 0.1622
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0024 0.0175 0.0121
Plasmodium falciparum protoporphyrinogen oxidase 0.0022 0.0138 0.0506
Echinococcus multilocularis 0.0022 0.0138 0.0083
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0279 0.477 0.4741
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.0451 0.0946
Leishmania major hypothetical protein, conserved 0.0039 0.0441 0.145
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0055 0.0473
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0053 0.07 0.0649
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0055 0.0473
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0312 0.5375 1
Plasmodium falciparum ferrodoxin reductase-like protein 0.0017 0.0055 0.0201
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0039 0.0441 0.145
Brugia malayi hypothetical protein 0.0022 0.0138 0.0207
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0055 0.0473
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0039 0.0441 0.145
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0039 0.0441 0.0388
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Chlamydia trachomatis protoporphyrinogen oxidase 0.0022 0.0138 0.1912
Leishmania major cAMP-specific phosphodiesterase, putative 0.0039 0.0441 0.145
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0041 0.0489 0.0982
Trichomonas vaginalis mercuric reductase, putative 0.0041 0.0489 0.4235
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0017 0.0055 0.011
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0041 0.0489 0.163
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0039 0.0441 0.1622
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0489 0.163
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0024 0.0175 0.0121
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0041 0.0489 0.1798
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0053 0.07 0.1607
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0017 0.0055 0.0473
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0289
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0138 0.0506
Entamoeba histolytica hypothetical protein 0.0062 0.0859 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0041 0.0489 0.163
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0039 0.0441 0.3819
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1154 1
Brugia malayi glutathione reductase 0.0165 0.2718 0.6633
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0039 0.0441 0.145
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0017 0.0055 0.0102
Schistosoma mansoni tumor necrosis factor receptor related 0.0037 0.0403 0.035
Toxoplasma gondii NADPH-glutathione reductase 0.0041 0.0489 0.1025
Toxoplasma gondii selenide, water dikinase 0.0017 0.0055 0.0115
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0017 0.0055 0.011
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0039 0.0441 0.0388
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0017 0.0055 0.011
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0441 0.1622
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0078 0.1154 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.07 0.6064
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0055 0.0115
Echinococcus granulosus netrin receptor unc 5 0.0024 0.0175 0.0121
Loa Loa (eye worm) hypothetical protein 0.0024 0.0175 0.0366
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0055 0.0473
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0022 0.0138 0.0256
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0022 0.0138 0.0506
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0039 0.0441 0.3819
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0017 0.0055 0.0102
Plasmodium falciparum thioredoxin reductase 0.0165 0.2718 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0039 0.0441 0.0962
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.024 0.407 0.4037
Echinococcus granulosus geminin 0.0426 0.7423 0.7409
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0039 0.0441 0.145
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Loa Loa (eye worm) hypothetical protein 0.0279 0.477 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0441 0.1622
Mycobacterium ulcerans ferredoxin reductase 0.0017 0.0055 0.0102
Mycobacterium ulcerans monoxygenase 0.0017 0.0055 0.0102
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0078 0.1154 1
Mycobacterium ulcerans dehydrogenase 0.0022 0.0138 0.0256
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0041 0.0489 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0039 0.0441 0.3819
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0279 0.477 0.4741
Loa Loa (eye worm) hypothetical protein 0.0039 0.0451 0.0946
Mycobacterium ulcerans oxidoreductase 0.0022 0.0138 0.0256
Trypanosoma cruzi UDP-galactopyranose mutase 0.0022 0.0138 0.0312
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0041 0.0489 0.163
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0078 0.1154 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0078 0.1154 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0039 0.0441 0.3819
Brugia malayi Uncoordinated protein 44 0.0024 0.0175 0.0299
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0138 0.0083
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0017 0.0055 0.011
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0078 0.1154 0.4129
Loa Loa (eye worm) hypothetical protein 0.0053 0.07 0.1467
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0055 0.0473
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0022 0.0138 0.0506
Treponema pallidum NADH oxidase 0.0041 0.0489 1
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0037 0.0403 0.035
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0055 0.0473
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0017 0.0055 0.0102
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0022 0.0138 0.0083
Mycobacterium ulcerans glutamate synthase subunit beta 0.0017 0.0055 0.0102
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0037 0.0403 0.035
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0017 0.0055 0.0201
Plasmodium falciparum glutathione reductase 0.0041 0.0489 0.1798
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0039 0.0441 0.0388
Leishmania major hypothetical protein, conserved 0.0039 0.0441 0.145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0489 0.163
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0489 0.163
Brugia malayi Death domain containing protein 0.0024 0.0175 0.0299
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.0451 0.0988
Loa Loa (eye worm) hypothetical protein 0.0039 0.0441 0.0924
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0078 0.1154 0.1106
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0039 0.0441 0.1622
Plasmodium vivax ferrodoxin reductase, putative 0.0017 0.0055 0.0201
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0055 0.0201
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0022 0.0138 0.0083
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0041 0.0489 0.0909
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0078 0.1154 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0039 0.0441 0.0388
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0041 0.0489 0.1798
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0017 0.0055 0.1118
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0055 0.0473
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0489 0.163
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0078 0.1154 0.1106
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0017 0.0055 0.0102
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Mycobacterium ulcerans monoamine oxidase 0.0022 0.0138 0.0256
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.024 0.407 0.4037
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0312 0.5375 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0039 0.0441 0.0962
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0017 0.0055 0.1118
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0441 0.3819
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0138 0.0083
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0078 0.1154 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0039 0.0441 0.0388
Brugia malayi Protein kinase domain containing protein 0.0024 0.0175 0.0299
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0039 0.0441 0.0388
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0041 0.0489 0.163
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0041 0.0489 0.0982
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0279 0.477 0.4741
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0039 0.0441 0.0962
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0441 0.3819
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0053 0.07 0.0649
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0138 0.0276
Loa Loa (eye worm) hypothetical protein 0.0039 0.0441 0.0924
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0017 0.0055 0.0115
Loa Loa (eye worm) glutathione reductase 0.0165 0.2718 0.5698
Leishmania major UDP-galactopyranose mutase 0.0022 0.0138 0.0312
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0055 0.0115
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0017 0.0055 0.0102
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0441 0.1622
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.0451 0.0988
Echinococcus multilocularis Ankyrin 0.0024 0.0175 0.0121
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0017 0.0055 0.0102
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0041 0.0489 0.0909
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0078 0.1154 1
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0017 0.0055 0.1118
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0175 0.03
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0062 0.0859 0.0809
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0441 0.1622
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0441 0.145
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0064 0.0895 0.7755
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.029 0.4978 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Loa Loa (eye worm) hypothetical protein 0.0024 0.0175 0.0366
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0062 0.0859 0.0809
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0078 0.1154 0.4129
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0041 0.0489 0.0437
Echinococcus multilocularis protoporphyrinogen oxidase 0.0022 0.0138 0.0083
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0037 0.0403 0.035
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0053 0.07 0.0649
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0017 0.0055 0.0115
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Schistosoma mansoni hypothetical protein 0.0426 0.7423 0.7409
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0489 0.163
Trypanosoma brucei trypanothione reductase 0.0165 0.2718 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0115
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0078 0.1154 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0017 0.0055 0.011
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0022 0.0138 0.0083
Echinococcus multilocularis netrin receptor unc 5 0.0024 0.0175 0.0121
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0441 0.3819
Entamoeba histolytica hypothetical protein 0.0062 0.0859 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0039 0.0441 0.0388
Schistosoma mansoni netrin receptor unc5 0.0024 0.0175 0.0121
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0441 0.3819
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0289
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0039 0.0441 0.0388
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0017 0.0055 0.0102
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Onchocerca volvulus Netrin receptor homolog 0.0024 0.0175 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0454 0.3936
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Plasmodium vivax glutathione reductase, putative 0.0165 0.2718 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0039 0.0441 0.0388
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0289
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0041 0.0489 0.1798
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0017 0.0055 0.0473
Trichomonas vaginalis glutathione reductase, putative 0.0041 0.0489 0.4235
Schistosoma mansoni transcription factor LCR-F1 0.0062 0.0859 0.0809
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0441 0.3819
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0441 0.145
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0024 0.0175 0.0366
Echinococcus multilocularis thioredoxin glutathione reductase 0.0166 0.2741 0.2701
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0441 0.3819
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0039 0.0441 0.0388
Brugia malayi Thioredoxin reductase 0.0165 0.2718 0.6633
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0279 0.477 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0039 0.0441 0.0924
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0441 0.145
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0064 0.0895 0.7755
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Mycobacterium tuberculosis Probable dehydrogenase 0.0017 0.0055 0.011
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0055 0.0201
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0279 0.477 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0441 0.145
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0078 0.1154 0.4129
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0039 0.0441 0.0388
Echinococcus multilocularis geminin 0.0426 0.7423 0.7409
Toxoplasma gondii hypothetical protein 0.004 0.0454 0.0952
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0017 0.0055 0.011
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0041 0.0489 0.0909
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0041 0.0489 0.1798
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.07 0.6064
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0022 0.0138 0.2816
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0039 0.0441 0.0388
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0039 0.0441 0.3819
Mycobacterium tuberculosis Possible oxidoreductase 0.0022 0.0138 0.0276
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0041 0.0489 0.0437
Plasmodium falciparum phosphodiesterase gamma, putative 0.0039 0.0441 0.1622
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0475
Leishmania major trypanothione reductase 0.0165 0.2718 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0165 0.2718 0.5459
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0489 0.163
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0289
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0055 0.0115
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0017 0.0055 0.1118
Entamoeba histolytica hypothetical protein 0.0062 0.0859 1
Entamoeba histolytica hypothetical protein 0.0062 0.0859 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Onchocerca volvulus 0.0022 0.0138 0.6919
Schistosoma mansoni hypothetical protein 0.0062 0.0859 0.0809
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0041 0.0489 0.163
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0289
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0041 0.0489 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0489 0.163
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0055 0.0473
Trypanosoma cruzi trypanothione reductase, putative 0.0165 0.2718 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0017 0.0055 0.011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0039 0.0441 0.145
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0022 0.0138 0.0506
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0039 0.0441 0.1622
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0053 0.07 0.1607
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0055 0.0115
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0041 0.0489 0.163
Giardia lamblia hypothetical protein 0.0039 0.0441 0.0819
Schistosoma mansoni hypothetical protein 0.0426 0.7423 0.7409
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0441 0.145
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0078 0.1154 0.4129
Loa Loa (eye worm) PDE1B protein 0.0039 0.0441 0.0924
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0039 0.0441 0.0388
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0138 0.0506
Mycobacterium ulcerans NADH dehydrogenase 0.0017 0.0055 0.0102
Echinococcus granulosus death domain containing protein 0.0024 0.0175 0.0121
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0441 0.145
Toxoplasma gondii thioredoxin reductase 0.0165 0.2718 0.5698
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0441 0.145
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0041 0.0489 1
Plasmodium falciparum glutathione reductase 0.0165 0.2718 1
Giardia lamblia Hypothetical protein 0.0039 0.0441 0.0819
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0024 0.0175 0.0121
Giardia lamblia NADH oxidase lateral transfer candidate 0.0041 0.0489 0.0921
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0441 0.3819
Mycobacterium tuberculosis Probable reductase 0.0017 0.0055 0.011
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0041 0.0489 0.1025
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0078 0.1154 0.4129
Toxoplasma gondii histone lysine-specific demethylase 0.0022 0.0138 0.0289
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0078 0.1154 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0041 0.0489 0.163
Plasmodium vivax thioredoxin reductase, putative 0.0165 0.2718 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0041 0.0489 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0041 0.0489 0.0437
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.024 0.407 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Brugia malayi SWIRM domain containing protein 0.0022 0.0138 0.0207
Schistosoma mansoni hypothetical protein 0.0027 0.0227 0.0173
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Schistosoma mansoni amine oxidase 0.0022 0.0138 0.0083
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0055 0.0473
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0022 0.0138 0.0289
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0041 0.0489 0.163
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0041 0.0489 0.163
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0017 0.0055 0.011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0039 0.0441 0.0924
Trypanosoma cruzi UDP-galactopyranose mutase 0.0022 0.0138 0.0312
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0175 0.03
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0454 0.3936
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0017 0.0055 0.1118
Schistosoma mansoni ankyrin 23/unc44 0.0024 0.0175 0.0121
Schistosoma mansoni microtubule-associated protein tau 0.0569 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0441 0.145
Plasmodium falciparum thioredoxin reductase 0.0041 0.0489 0.1798
Schistosoma mansoni hypothetical protein 0.0024 0.0175 0.0121
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0175 0.0299
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0017 0.0055 0.0201
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.024 0.407 0.8533

Activities

Activity type Activity value Assay description Source Reference
CD50 (functional) = 0.4 mg kg-1 Trypanocidal Activity at I.C.E. value 0.85 when administered subcutaneously. ChEMBL. 2296025
CD50 (functional) = 0.4 mg kg-1 Trypanocidal Activity at I.C.E. value 0.85 when administered subcutaneously. ChEMBL. 2296025
CD50 (functional) = 53 mg kg-1 Trypanocidal Activity at I.C.E. value 0.30 when administered perorally. ChEMBL. 2296025
CD50 (functional) = 53 mg kg-1 Trypanocidal Activity at I.C.E. value 0.30 when administered perorally. ChEMBL. 2296025

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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