Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5303 | 0.5303 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.8776 | 0.8333 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.266 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5868 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.5868 | 0.1628 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5303 | 0.36 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.266 | 0.266 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.8776 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.266 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5868 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.8776 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.266 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.8776 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5868 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.266 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.8776 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.266 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.266 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.266 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5868 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.8776 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.8776 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.5868 | 0.5868 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.8776 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.5868 | 0.1628 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.266 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.8776 | 0.8776 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5623 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.