Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis | 4'-phosphopantetheinyl transferase ffp | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 198 aa | 28.3 % |
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Trichomonas vaginalis | conserved hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 197 aa | 22.3 % |
Onchocerca volvulus | 4'-phosphopantetheinyl transferase ffp | 224 aa | 186 aa | 26.3 % | |
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0093 | 0.4173 | 0.8919 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0 | 0.5 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0028 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.2768 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.01 | 0.4669 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0028 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0093 | 0.4173 | 0.8919 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.2768 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.2768 | 0.2716 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.01 | 0.4669 | 0.4631 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.2768 | 0.2716 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.01 | 0.4669 | 0.4631 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 1 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.01 | 0.4669 | 0.4631 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0063 | 0.2274 | 0.4791 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0028 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0183 | 1 | 1 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.01 | 0.4669 | 0.5 | |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.2768 | 0.2716 |
Brugia malayi | hypothetical protein | 0.0071 | 0.2768 | 0.5864 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0028 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.2768 | 1 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.4669 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.2768 | 0.2716 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0093 | 0.4173 | 0.8919 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.2274 | 0.2219 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.4173 | 0.8919 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2274 | 0.4791 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0028 | 0 | 0.5 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0028 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.2768 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. Gel-Based Assay for Inhibitos of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase): Chemistry Optimization Follow up. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.