Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0055 | 0.8627 | 0.8627 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.988 | 0.988 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0055 | 0.8627 | 0.8627 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.988 | 0.988 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.8386 | 0.8386 |
Brugia malayi | hypothetical protein | 0.002 | 0.0137 | 0.0137 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.2729 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0029 | 0.2493 | 0.2493 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2729 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0055 | 0.8627 | 0.8627 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.2729 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2729 | 0.2729 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.155 | 0.155 |
Onchocerca volvulus | 0.0055 | 0.8627 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.2729 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.155 | 0.155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.2729 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5303 | 0.5303 |
Echinococcus granulosus | intermediate filament protein | 0.0055 | 0.8627 | 0.8627 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.988 | 0.988 |
Brugia malayi | intermediate filament protein | 0.0055 | 0.8627 | 0.8627 |
Schistosoma mansoni | intermediate filament proteins | 0.0055 | 0.8627 | 0.8627 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2729 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1792 | 0.1792 |
Echinococcus multilocularis | lamin | 0.0055 | 0.8627 | 0.8627 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0027 | 0.1792 | 0.1792 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.8627 | 0.8627 |
Onchocerca volvulus | 0.0055 | 0.8627 | 0.5 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.2493 | 0.2493 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5303 | 0.5303 |
Echinococcus granulosus | lamin | 0.0055 | 0.8627 | 0.8627 |
Echinococcus granulosus | lamin dm0 | 0.0055 | 0.8627 | 0.8627 |
Echinococcus multilocularis | lamin dm0 | 0.0055 | 0.8627 | 0.8627 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0027 | 0.1792 | 0.1792 |
Schistosoma mansoni | lamin | 0.0055 | 0.8627 | 0.8627 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5303 | 0.5303 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2729 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0055 | 0.8627 | 0.8627 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2729 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.2729 | 0.2729 |
Echinococcus multilocularis | musashi | 0.0055 | 0.8627 | 0.8627 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.988 | 0.988 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 67.51 uM | PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.0073 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.