Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis | 4'-phosphopantetheinyl transferase ffp | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Entamoeba histolytica | hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 198 aa | 28.3 % |
Trichomonas vaginalis | conserved hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 197 aa | 22.3 % |
Onchocerca volvulus | 4'-phosphopantetheinyl transferase ffp | 224 aa | 186 aa | 26.3 % | |
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0074 | 0.5707 | 0.5707 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.5707 | 0.5707 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.5707 | 0.5707 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.5707 | 0.5707 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.5707 | 0.5707 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.2811 | 0.2811 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2811 | 0.2811 |
Onchocerca volvulus | 0.01 | 1 | 0.5 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.5707 | 0.5707 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.2811 | 0.2811 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.5707 | 0.5707 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.5707 | 0.5707 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.2811 | 0.2811 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.01 | 1 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.01 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.5707 | 0.5707 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.5707 | 0.5707 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.01 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.5707 | 0.5707 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. Gel-Based Assay for Inhibitos of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase): Chemistry Optimization Follow up. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.