Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.0158 | 0.0304 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.1148 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.1286 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.1449 | 0.1193 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5204 | 0.5149 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1286 | 0.1187 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.1148 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1449 | 0.1352 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.1148 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.1449 | 0.1193 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.1148 | 0.0883 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.1286 | 1 |
Onchocerca volvulus | 0.0031 | 0.1449 | 1 | |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.1148 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.1148 | 1 |
Brugia malayi | hypothetical protein | 0.0018 | 0.046 | 0.0174 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0593 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.1449 | 0.2785 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5204 | 0.5149 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0593 | 0.0486 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.1148 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1286 | 1 |
Onchocerca volvulus | 0.0031 | 0.1449 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0593 | 0.0486 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.1449 | 0.2785 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5204 | 0.506 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5204 | 0.5149 |
Echinococcus multilocularis | lamin | 0.0031 | 0.1449 | 0.2785 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5204 | 1 |
Echinococcus multilocularis | musashi | 0.0031 | 0.1449 | 0.2785 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5204 | 0.506 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1148 | 0.1047 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.1148 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.1148 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.1286 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5204 | 0.506 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0593 | 0.0486 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.1148 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.1286 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.1286 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.1148 | 0.0883 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1148 | 0.1047 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1148 | 0.1047 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.1148 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0593 | 0.0486 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.1449 | 0.2785 |
Echinococcus granulosus | lamin | 0.0031 | 0.1449 | 0.2785 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0593 | 0.139 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.1449 | 0.1352 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.1449 | 0.1352 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0593 | 0.0486 |
Schistosoma mansoni | lamin | 0.0031 | 0.1449 | 0.2785 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.1148 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.0158 | 0.0304 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0135 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1286 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.1449 | 0.2785 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.1148 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.1286 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1403 | 0.1306 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0291 | 0.018 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5204 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.1148 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.1148 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.1148 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0158 | 0.0046 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.1449 | 0.2785 |
Brugia malayi | hypothetical protein | 0.0029 | 0.1286 | 0.1025 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5204 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5204 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5204 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5204 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5204 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.1148 | 0.0883 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.