Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 4 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0011 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0401 | 0.0401 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2387 | 0.2387 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3173 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3173 | 0.3173 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3173 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1468 | 0.1468 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2387 | 0.2387 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3173 | 0.3173 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3173 | 0.3173 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3173 | 0.3173 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2387 | 0.2387 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0401 | 0.1265 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0401 | 0.0401 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2387 | 0.2387 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0401 | 0.0401 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0401 | 0.0401 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3173 | 0.3173 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0401 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1468 | 0.1468 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0401 | 0.1265 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0401 | 0.1265 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1468 | 0.4626 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3173 | 0.3173 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.122 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.