Detailed information for compound 1703061

Basic information

Technical information
  • TDR Targets ID: 1703061
  • Name: 3-(4-methylphenyl)-1,5-di(phenyl)-4,5-dihydro pyrazole
  • MW: 312.408 | Formula: C22H20N2
  • H donors: 0 H acceptors: 0 LogP: 5.39 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1ccccc1
  • InChi: 1S/C22H20N2/c1-17-12-14-18(15-13-17)21-16-22(19-8-4-2-5-9-19)24(23-21)20-10-6-3-7-11-20/h2-15,22H,16H2,1H3
  • InChiKey: GDBZFBSFHRVCHG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,5-Diphenyl-3-p-tolyl-4,5-dihydro-1H-pyrazole
  • ST5229154
  • BAS 00430700

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fyn 0.0245 0.0458 0.0458
Schistosoma mansoni adapter molecule crk 0.006 0.0055 0.0055
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0789 0.1642 1
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0162 0.0277 0.0287
Echinococcus granulosus tyrosine protein kinase shark 0.0041 0.0013 0.0013
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0627 0.1289 0.1289
Onchocerca volvulus 0.0041 0.0013 0.0299
Schistosoma mansoni tyrosine kinase 0.007 0.0077 0.0077
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0162 0.0277 0.0449
Echinococcus multilocularis tyrosine protein kinase Blk 0.0215 0.0393 0.0393
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0245 0.0458 0.0458
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0162 0.0277 0.0287
Loa Loa (eye worm) TK/EGFR protein kinase 0.0322 0.0625 0.0648
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0162 0.0277 0.0277
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0398 0.0791 0.1097
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0162 0.0277 0.0277
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0162 0.0277 0.0277
Echinococcus granulosus tyrosine protein kinase ABL1 0.0041 0.0013 0.0013
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0013 0.0299
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0041 0.0013 0.0013
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0627 0.1289 0.1289
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1763 0.3762 0.3762
Echinococcus multilocularis cathepsin b 0.0171 0.0296 0.0296
Brugia malayi Protein kinase domain containing protein 0.0041 0.0013 0.0013
Brugia malayi Protein kinase domain containing protein 0.0041 0.0013 0.0013
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0245 0.0458 0.0458
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0398 0.0791 0.0791
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0627 0.1289 0.3427
Echinococcus granulosus tyrosine protein kinase Fyn 0.0245 0.0458 0.0458
Brugia malayi Protein kinase domain containing protein 0.0041 0.0013 0.0013
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.4627 1 1
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0071 0.0074
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0245 0.0458 0.0458
Brugia malayi Variant SH3 domain containing protein 0.006 0.0055 0.0057
Treponema pallidum pyruvate carboxylase subunit B 0.0162 0.0277 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0245 0.0458 0.0458
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0041 0.0013 0.0013
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0162 0.0277 0.0277
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.3349 0.7216 1
Brugia malayi Furin-like cysteine rich region family protein 0.0322 0.0625 0.0648
Schistosoma mansoni aspartate carbamoyltransferase 0.0398 0.0791 0.0791
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0071 0.1676
Schistosoma mansoni pyruvate carboxylase 0.1763 0.3762 0.3762
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0013 0.0013
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0162 0.0277 0.0736
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0627 0.1289 0.1289
Echinococcus granulosus tyrosine protein kinase HCK 0.0185 0.0327 0.0327
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0013 0.0013
Echinococcus multilocularis chromobox protein 1 0.0068 0.0071 0.0071
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.0054 0.0054
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0627 0.1289 0.2092
Mycobacterium ulcerans pyruvate carboxylase 0.1763 0.3762 1
Onchocerca volvulus 0.023 0.0425 1
Echinococcus granulosus Biotin lipoyl attachment 0.0162 0.0277 0.0277
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0162 0.0277 0.0277
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0162 0.0277 0.0736
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.0031
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0013 0.0013
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0245 0.0458 0.0458
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0162 0.0277 0.0277
Schistosoma mansoni chromobox protein 0.0068 0.0071 0.0071
Brugia malayi Carboxyl transferase domain containing protein 0.4465 0.9647 1
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.1763 0.3762 1
Brugia malayi hypothetical protein 0.0041 0.0013 0.0013
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0627 0.1289 0.3427
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0162 0.0277 0.0449
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0627 0.1289 0.3427
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0011 0.0011
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0162 0.0277 0.0736
Echinococcus multilocularis chromobox protein 1 0.0068 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0162 0.0277 0.0287
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0013 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0006 0.0152
Schistosoma mansoni tyrosine kinase 0.0109 0.0161 0.0161
Echinococcus granulosus tyrosine protein kinase Blk 0.0215 0.0393 0.0393
Echinococcus granulosus jumonji domain containing protein 0.0039 0.001 0.001
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0171 0.0296 0.0296
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.1763 0.3762 1
Onchocerca volvulus 0.0041 0.0013 0.0299
Onchocerca volvulus 0.0041 0.0013 0.0299
Echinococcus multilocularis tyrosine protein kinase HCK 0.0185 0.0327 0.0327
Echinococcus granulosus c src tyrosine kinase 0.007 0.0077 0.0077
Schistosoma mansoni acetyl-CoA carboxylase 0.4627 1 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0028 0.0028
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.1763 0.3762 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0126 0.0126
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0215 0.0393 0.0393
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0177 0.0309 0.0309
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.1763 0.3762 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0296 0.0296
Brugia malayi SH2 domain containing protein 0.0041 0.0013 0.0013
Brugia malayi Heterochromatin protein 1 0.0068 0.0071 0.0074
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0051 0.0053
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0162 0.0277 0.0384
Echinococcus granulosus tyrosine protein kinase Src42A 0.0205 0.037 0.037
Echinococcus granulosus tyrosine protein kinase Srms 0.0041 0.0013 0.0013
Leishmania major carbamoyl-phosphate synthase, putative 0.0398 0.0791 0.0791
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0006 0.0152
Echinococcus multilocularis tumor protein p63 0.0328 0.0638 0.0638
Schistosoma mansoni tyrosine kinase 0.0167 0.0287 0.0287
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0162 0.0277 0.0277
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1763 0.3762 0.3762
Echinococcus multilocularis tyrosine protein kinase shark 0.0041 0.0013 0.0013
Loa Loa (eye worm) TK/INSR protein kinase 0.0109 0.0161 0.0166
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0013 0.0013
Brugia malayi Variant SH3 domain containing protein 0.006 0.0055 0.0057
Echinococcus multilocularis Biotin lipoyl attachment 0.0162 0.0277 0.0277
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0789 0.1642 1
Entamoeba histolytica protein kinase, putative 0.0185 0.0327 0.1927
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0162 0.0277 0.0277
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0162 0.0277 0.0277
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.001 0.001
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0162 0.0277 0.0736
Brugia malayi Protein kinase domain containing protein 0.0109 0.0161 0.0166
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0162 0.0277 0.0384
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0398 0.0791 0.1284
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0162 0.0277 0.0277
Echinococcus multilocularis cathepsin b 0.0171 0.0296 0.0296
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.4627 1 1
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0162 0.0277 0.0736
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0245 0.0458 0.0458
Schistosoma mansoni tyrosine kinase 0.0245 0.0458 0.0458
Brugia malayi SH2 domain containing protein 0.0041 0.0013 0.0013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0296 0.0296
Trypanosoma brucei unspecified product 0.1159 0.2447 0.2447
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0627 0.1289 0.3427
Loa Loa (eye worm) sex muscle abnormal protein 5 0.006 0.0055 0.0057
Brugia malayi Sex muscle abnormal protein 5 0.006 0.0055 0.0057
Echinococcus granulosus tyrosine kinase 0.0215 0.0393 0.0393
Leishmania major carboxylase, putative 0.1763 0.3762 0.3762
Schistosoma mansoni tyrosine kinase 0.0177 0.0309 0.0309
Brugia malayi cathepsin B-like cysteine proteinase 0.0171 0.0296 0.0307
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0171 0.0296 0.048
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0013 0.0299
Loa Loa (eye worm) SRC-1 0.0245 0.0458 0.0474
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0398 0.0791 0.0791
Schistosoma mansoni tyrosine kinase 0.0245 0.0458 0.0458
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0013 0.0013
Onchocerca volvulus 0.004 0.0011 0.0261
Echinococcus granulosus tyrosine protein kinase Src42A 0.0245 0.0458 0.0458
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0205 0.037 0.037
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0245 0.0458 0.0458
Brugia malayi Protein kinase domain containing protein 0.0041 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0162 0.0277 0.0287
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0162 0.0277 0.0277
Schistosoma mansoni tyrosine kinase 0.0322 0.0625 0.0625
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0126 0.0126
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0162 0.0277 0.0277
Trypanosoma cruzi acetyl-CoA carboxylase 0.2865 0.6162 1
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.1763 0.3762 1
Toxoplasma gondii pyruvate carboxylase 0.1763 0.3762 0.3762
Echinococcus granulosus NCK adaptor protein 0.006 0.0055 0.0055
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0162 0.0277 0.0277
Echinococcus multilocularis 0.0097 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0162 0.0277 0.0287
Echinococcus multilocularis growth factor receptor bound protein 2 0.006 0.0055 0.0055
Echinococcus multilocularis epidermal growth factor receptor 0.0322 0.0625 0.0625
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.4627 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.007 0.0077 0.0077
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0627 0.1289 0.1289
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.1763 0.3762 0.3762
Schistosoma mansoni tyrosine kinase 0.0109 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0171 0.0296 0.0307
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0245 0.0458 0.0458
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0011 0.0011
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0627 0.1289 0.3427
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0162 0.0277 0.0277
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0627 0.1289 0.3427
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0162 0.0277 0.0277
Schistosoma mansoni nck2/grb4 0.006 0.0055 0.0055
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.041 0.1091
Echinococcus multilocularis epidermal growth factor receptor 0.0177 0.0309 0.0309
Loa Loa (eye worm) TK protein kinase 0.0215 0.0393 0.0407
Echinococcus granulosus chromobox protein 1 0.0068 0.0071 0.0071
Brugia malayi Protein kinase domain containing protein 0.0041 0.0013 0.0013
Brugia malayi SRC-1 0.0245 0.0458 0.0474
Brugia malayi Pre-SET motif family protein 0.0202 0.0364 0.0377
Onchocerca volvulus 0.0041 0.0013 0.0299
Schistosoma mansoni tyrosine kinase 0.007 0.0077 0.0077
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.4465 0.9647 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0245 0.0458 0.0458
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0162 0.0277 0.0736
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0162 0.0277 0.0449
Echinococcus granulosus tyrosine kinase 0.0041 0.0013 0.0013
Echinococcus multilocularis insulin receptor 0.0109 0.0161 0.0161
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0162 0.0277 0.0277
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0162 0.0277 0.0277
Brugia malayi chromobox protein homolog 3 0.0038 0.0006 0.0007
Schistosoma mansoni tyrosine kinase 0.0041 0.0013 0.0013
Toxoplasma gondii cathepsin B 0.006 0.0054 0.0054
Echinococcus granulosus epidermal growth factor receptor 0.0322 0.0625 0.0625
Echinococcus granulosus tyrosine protein kinase Lyn 0.0245 0.0458 0.0458
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0398 0.0791 0.1476
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0627 0.1289 0.3427
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.006 0.0055 0.0055
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0627 0.1289 0.2905
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.3349 0.7216 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0041 0.0013 0.0013
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0013 0.0013
Schistosoma mansoni tyrosine kinase 0.0167 0.0287 0.0287
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.007 0.0077 0.0077
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1763 0.3762 0.3762
Loa Loa (eye worm) hypothetical protein 0.0038 0.0006 0.0007
Schistosoma mansoni tyrosine kinase 0.0177 0.0309 0.0309
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.1763 0.3762 0.3762
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0215 0.0393 0.0393
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0627 0.1289 0.3427
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0398 0.0791 0.1284
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.0054 0.0087
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1763 0.3762 0.3762
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0071 0.1676
Echinococcus multilocularis NCK adaptor protein 0.006 0.0055 0.0055
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0013 0.0013
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0162 0.0277 0.0449
Schistosoma mansoni tyrosine kinase 0.0041 0.0013 0.0013
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0398 0.0791 0.0791
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0627 0.1289 0.1289
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0162 0.0277 0.0277
Echinococcus granulosus tyrosine protein kinase Btk29A 0.007 0.0077 0.0077
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0109 0.0161 0.0161
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0245 0.0458 0.0458
Loa Loa (eye worm) variant SH3 domain-containing protein 0.006 0.0055 0.0057
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.1763 0.3762 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0245 0.0458 0.0458
Brugia malayi Tyrosine-protein kinase abl-1 0.007 0.0077 0.008
Schistosoma mansoni growth factor receptor-bound protein 0.006 0.0055 0.0055
Leishmania major acetyl-CoA carboxylase, putative 0.4627 1 1
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0627 0.1289 0.2092
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0364 0.0377
Echinococcus granulosus growth factor receptor bound protein 2 0.006 0.0055 0.0055
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0627 0.1289 0.3427
Echinococcus granulosus epidermal growth factor receptor 0.0177 0.0309 0.0309
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.0054 0.0054
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0627 0.1289 0.3427
Echinococcus granulosus cathepsin b 0.0171 0.0296 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.0054 0.1268
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0162 0.0277 0.0736
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0627 0.1289 0.1289
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0162 0.0277 0.0277
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0013 0.0013
Brugia malayi jmjC domain containing protein 0.0093 0.0126 0.013
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0162 0.0277 0.0449
Loa Loa (eye worm) TK protein kinase 0.0185 0.0327 0.0339
Loa Loa (eye worm) cathepsin B 0.006 0.0054 0.0056
Schistosoma mansoni chromobox protein 0.0068 0.0071 0.0071
Toxoplasma gondii carbamoylphosphate synthetase 0.0398 0.0791 0.0791
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0296 0.0296
Onchocerca volvulus 0.0048 0.0028 0.067
Schistosoma mansoni tyrosine kinase 0.0167 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.006 0.0055 0.0057
Trichomonas vaginalis set domain proteins, putative 0.023 0.0425 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0006 0.0152
Echinococcus granulosus tyrosine protein kinase Fyn 0.0245 0.0458 0.0458
Echinococcus granulosus tumor protein p63 0.0328 0.0638 0.0638
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0041 0.0013 0.0013
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0162 0.0277 0.0277
Echinococcus multilocularis tyrosine kinase 0.0041 0.0013 0.0013
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1763 0.3762 0.6105
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0627 0.1289 0.1289
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0029
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0162 0.0277 0.0287
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0398 0.0791 0.2104
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0627 0.1289 0.3427
Brugia malayi protein-tyrosine kinase 0.0215 0.0393 0.0407
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.0054 0.0054
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.1763 0.3762 0.3762
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.007 0.0077 0.0077
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0627 0.1289 0.3233
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0162 0.0277 0.0277
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1763 0.3762 0.6105
Trypanosoma brucei acetyl-CoA carboxylase 0.4627 1 1
Echinococcus multilocularis c src tyrosine kinase 0.007 0.0077 0.0077
Mycobacterium ulcerans hypothetical protein 0.0162 0.0277 0.0736
Echinococcus granulosus cathepsin b 0.0171 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0041 0.0013 0.0013
Plasmodium falciparum carbamoyl phosphate synthetase 0.0398 0.0791 0.0742
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0162 0.0277 0.0449
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0013 0.0013
Loa Loa (eye worm) TK/FER protein kinase 0.0041 0.0013 0.0013
Onchocerca volvulus 0.0041 0.0013 0.0299
Chlamydia trachomatis biotin carboxylase 0.1601 0.3409 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0109 0.0161 0.0161
Echinococcus granulosus insulin receptor 0.0109 0.0161 0.0161
Schistosoma mansoni growth factor receptor-bound protein 0.006 0.0055 0.0055
Echinococcus multilocularis tyrosine protein kinase Srms 0.0215 0.0393 0.0393
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.1763 0.3762 1
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0084 0.0084
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0245 0.0458 0.0458
Onchocerca volvulus 0.0041 0.0013 0.0299
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0627 0.1289 0.2092
Echinococcus granulosus chromobox protein 1 0.0068 0.0071 0.0071
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0162 0.0277 0.0449

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 20 uM PubChem BioAssay. High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, compounds from Powder Set 01. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) 20 uM PubChem BioAssay. High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, compounds from Powder Set 01. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) 20 uM PubChem BioAssay. High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Lethal Factor protease, compounds from Powder Set 01. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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