Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 alpha | 0.0033 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0033 | 0.0302 | 0.0302 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0033 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0033 | 0.0302 | 0.0302 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0033 | 0.0302 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0033 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0302 | 0.0302 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0033 | 0.0302 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0033 | 0.0302 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0033 | 0.0302 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0033 | 0.0302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0302 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0033 | 0.0302 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0033 | 0.0302 | 0.0302 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0033 | 0.0302 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0033 | 0.0302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0033 | 0.0302 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0033 | 0.0302 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0033 | 0.0302 | 0.0302 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0033 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0033 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0033 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0033 | 0.0302 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0033 | 0.0302 | 0.0302 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0033 | 0.0302 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0033 | 0.0302 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0033 | 0.0302 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0033 | 0.0302 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0033 | 0.0302 | 0.0302 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0033 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0302 | 0.0302 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0033 | 0.0302 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0033 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0033 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0302 | 0.0302 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0033 | 0.0302 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0033 | 0.0302 | 0.0302 |
Schistosoma mansoni | thyroid hormone receptor | 0.0033 | 0.0302 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0033 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0033 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0033 | 0.0302 | 0.0302 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0033 | 0.0302 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0033 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0033 | 0.0302 | 0.0302 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0033 | 0.0302 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0033 | 0.0302 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0033 | 0.0302 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0033 | 0.0302 | 0.0302 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0033 | 0.0302 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0033 | 0.0302 | 0.0302 |
Brugia malayi | nuclear hormone receptor | 0.0033 | 0.0302 | 0.0302 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0033 | 0.0302 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0033 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0033 | 0.0302 | 0.0302 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0033 | 0.0302 | 0.0302 |
Schistosoma mansoni | coup transcription factor | 0.0033 | 0.0302 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0033 | 0.0302 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0033 | 0.0302 | 1 |
Brugia malayi | steroid hormone receptor | 0.0033 | 0.0302 | 0.0302 |
Onchocerca volvulus | Bile acid receptor homolog | 0.054 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0033 | 0.0302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0302 | 0.0302 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0033 | 0.0302 | 0.0302 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0033 | 0.0302 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.