Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.2589 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.2589 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.2589 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.118 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.118 | 0.118 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.118 | 0.118 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.118 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.118 | 0.118 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.2589 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.2589 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.2589 | 0.2589 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.118 | 0.118 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.118 | 0.118 |
Onchocerca volvulus | 0.001 | 0.118 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.118 | 0.118 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.118 | 0.118 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.2589 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.118 | 0.118 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.118 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.2589 | 0.2589 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.118 | 0.118 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.118 | 0.118 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.118 | 0.118 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.2589 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.118 | 0.118 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.2589 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.118 | 0.118 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.