Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0051 | 0.023 | 0.0049 |
Echinococcus multilocularis | thymidylate synthase | 0.0107 | 0.0947 | 0.0947 |
Loa Loa (eye worm) | hypothetical protein | 0.0816 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0816 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0336 | 0.387 | 0.3784 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0078 | 0.057 | 0.057 |
Loa Loa (eye worm) | calcium channel | 0.0078 | 0.057 | 0.0439 |
Loa Loa (eye worm) | thymidylate synthase | 0.0107 | 0.0947 | 0.0821 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0816 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0044 | 0.0137 | 0.0137 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0336 | 0.387 | 0.387 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0107 | 0.0947 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0383 | 0.4468 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0078 | 0.057 | 0.057 |
Onchocerca volvulus | 0.0107 | 0.0947 | 0.5 | |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0336 | 0.387 | 0.387 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0078 | 0.057 | 0.0439 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0078 | 0.057 | 0.057 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.1504 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0044 | 0.0137 | 0.0137 |
Brugia malayi | hypothetical protein | 0.0051 | 0.023 | 0.0094 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0078 | 0.057 | 0.057 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0336 | 0.387 | 0.3784 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0336 | 0.387 | 0.8588 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0336 | 0.387 | 0.387 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.1504 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0107 | 0.0947 | 0.0947 |
Schistosoma mansoni | patched 1 | 0.0336 | 0.387 | 0.3784 |
Mycobacterium ulcerans | thymidylate synthase | 0.0107 | 0.0947 | 0.0821 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0816 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0078 | 0.057 | 0.057 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0383 | 0.4468 | 1 |
Brugia malayi | thymidylate synthase | 0.0107 | 0.0947 | 0.0821 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0044 | 0.0137 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0107 | 0.0947 | 0.0821 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0336 | 0.387 | 0.387 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0078 | 0.057 | 0.0439 |
Echinococcus multilocularis | protein dispatched 1 | 0.0336 | 0.387 | 0.387 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.1504 | 0.1346 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.057 | 0.0439 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0816 | 1 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0078 | 0.057 | 0.0439 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0107 | 0.0947 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0078 | 0.057 | 0.057 |
Schistosoma mansoni | voltage-gated cation channel | 0.0078 | 0.057 | 0.0439 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0383 | 0.4468 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0816 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0816 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0078 | 0.057 | 0.057 |
Echinococcus multilocularis | protein patched | 0.0336 | 0.387 | 0.387 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0051 | 0.023 | 0.1148 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0816 | 1 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0078 | 0.057 | 0.057 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.1504 | 0.1346 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0151 | 0.1504 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0383 | 0.4468 | 1 |
Brugia malayi | CHE-14 protein | 0.0336 | 0.387 | 0.3784 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0816 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0078 | 0.057 | 0.057 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.387 | 0.3784 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0078 | 0.057 | 0.057 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0336 | 0.387 | 0.387 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.