Detailed information for compound 1704209

Basic information

Technical information
  • TDR Targets ID: 1704209
  • Name: 4-[[2-(4-oxo-2-pyrrolidin-1-yl-1,3-thiazol-5- yl)acetyl]amino]-N-pentylbenzamide
  • MW: 416.537 | Formula: C21H28N4O3S
  • H donors: 2 H acceptors: 3 LogP: 2.73 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCNC(=O)c1ccc(cc1)NC(=O)CC1SC(=NC1=O)N1CCCC1
  • InChi: 1S/C21H28N4O3S/c1-2-3-4-11-22-19(27)15-7-9-16(10-8-15)23-18(26)14-17-20(28)24-21(29-17)25-12-5-6-13-25/h7-10,17H,2-6,11-14H2,1H3,(H,22,27)(H,23,26)
  • InChiKey: LLJJEJWYPHYJTO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[[2-(4-oxo-2-pyrrolidin-1-yl-thiazol-5-yl)acetyl]amino]-N-pentyl-benzamide
  • 4-[[1-oxo-2-(4-oxo-2-1-pyrrolidinyl-5-thiazolyl)ethyl]amino]-N-pentylbenzamide
  • N-amyl-4-[[2-(4-keto-2-pyrrolidin-1-yl-thiazol-5-yl)acetyl]amino]benzamide
  • 4-[2-(4-oxo-2-pyrrolidin-1-yl-1,3-thiazol-5-yl)ethanoylamino]-N-pentyl-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0443 0.4611 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0024 0.0024
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0024 0.0024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.052 0.052
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0052 0.0361
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0024 0.0024
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0389 0.4027 0.4027
Echinococcus multilocularis thymidylate synthase 0.0106 0.0988 0.0987
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0281 0.0559
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.052 0.052
Brugia malayi dihydrofolate reductase family protein 0.0043 0.0313 0.0312
Echinococcus multilocularis voltage dependent calcium channel 0.0077 0.0674 0.0673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.052 0.052
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0056 0.0056
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0052 0.0361
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0147
Schistosoma mansoni lipoxygenase 0.0054 0.043 0.0429
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0281 0.028
Trichomonas vaginalis conserved hypothetical protein 0.005 0.039 0.0798
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0211 0.0211
Echinococcus multilocularis follistatin 0.0019 0.0052 0.0052
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0056 0.0055
Echinococcus granulosus sterol regulatory element binding protein 0.0389 0.4027 0.4027
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0462 0.0462
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.052 0.052
Brugia malayi hypothetical protein 0.0028 0.0147 0.0147
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0028 0.0147 0.0147
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0052 0.0052
Echinococcus granulosus voltage dependent calcium channel 0.0016 0.0021 0.002
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0149 0.1453 1
Leishmania major DNA polymerase kappa, putative 0.0021 0.007 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0281 0.028
Schistosoma mansoni hypothetical protein 0.0019 0.0056 0.0055
Schistosoma mansoni agrin 0.0019 0.0052 0.0052
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.007 0.007
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.052 0.052
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0024 0.0024
Echinococcus granulosus thymidylate synthase 0.0106 0.0988 0.0987
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0052 0.0052
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.043 0.0429
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0023 0.0022
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0077 0.0674 0.0673
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0023 0.0022
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0376 0.0376
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0443 0.4611 1
Trypanosoma brucei unspecified product 0.0034 0.0211 0.0211
Brugia malayi Cathepsin L-like precursor 0.0016 0.0024 0.0024
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0077 0.0674 0.0673
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0176 0.0175
Echinococcus multilocularis cysteine protease 0.0016 0.0024 0.0024
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0052 0.0052
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0944 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0023 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0281 0.028
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0056 0.0219
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0147 0.1276
Loa Loa (eye worm) cysteine protease 0.0016 0.0024 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.052 0.052
Echinococcus granulosus agrin 0.0019 0.0052 0.0052
Brugia malayi SPARC precursor 0.0019 0.0052 0.0052
Onchocerca volvulus 0.0028 0.0147 0.1276
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.4027 0.8728
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0281 0.028
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0389 0.4027 0.4027
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0944 1 1
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.0313 0.0313
Mycobacterium ulcerans thymidylate synthase 0.0106 0.0988 0.0728
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0047 0.035 0.035
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0056 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.052 0.052
Schistosoma mansoni rab6-interacting 0.0019 0.0056 0.0055
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0024 1
Onchocerca volvulus 0.0028 0.0147 0.1276
Schistosoma mansoni organic anion transporter 0.0028 0.0147 0.0147
Entamoeba histolytica cysteine protease, putative 0.0016 0.0024 1
Toxoplasma gondii transporter, major facilitator family protein 0.0028 0.0147 0.1015
Echinococcus granulosus dihydrofolate reductase 0.0043 0.0313 0.0312
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0052 0.0361
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0077 0.0674 0.0673
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0944 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0176 0.0175
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0033 0.0198 0.0198
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0281 0.0559
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0944 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0024 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0281 0.028
Echinococcus multilocularis cysteine protease 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0147
Echinococcus granulosus Niemann Pick C1 protein 0.0389 0.4027 0.4027
Schistosoma mansoni organic anion transporter 0.0028 0.0147 0.0147
Leishmania major cathepsin L-like protease 0.0016 0.0024 0.0024
Echinococcus multilocularis expressed protein 0.0019 0.0052 0.0052
Echinococcus granulosus cathepsin l1 0.0016 0.0024 0.0024
Schistosoma mansoni lipoxygenase 0.0019 0.0056 0.0055
Echinococcus multilocularis dna polymerase kappa 0.004 0.0281 0.028
Loa Loa (eye worm) ctsf protein 0.0016 0.0024 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0281 0.028
Chlamydia trachomatis dihydrofolate reductase 0.0043 0.0313 0.5
Echinococcus granulosus RUN 0.0019 0.0056 0.0055
Leishmania major cathepsin L-like protease 0.0063 0.052 0.052
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0944 1 1
Onchocerca volvulus 0.0019 0.0056 0.0325
Loa Loa (eye worm) hypothetical protein 0.0389 0.4027 0.4027
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0047 0.035 0.035
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0147 0.1276
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0281 0.028
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0443 0.4611 1
Echinococcus granulosus follistatin 0.0019 0.0052 0.0052
Brugia malayi Doublecortin family protein 0.0019 0.0056 0.0055
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0052 0.0361
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0147 0.0147
Echinococcus multilocularis voltage dependent calcium channel 0.0077 0.0674 0.0673
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0149 0.1453 0.1452
Brugia malayi CHE-14 protein 0.0389 0.4027 0.4027
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0077 0.0674 0.0673
Brugia malayi Cathepsin L-like precursor 0.0016 0.0024 0.0024
Onchocerca volvulus 0.0019 0.0052 0.029
Trypanosoma cruzi MFS transporter, putative 0.0028 0.0147 0.0147
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0024 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0024
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0056 0.0055
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0077 0.0674 0.0674
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0056 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.052 0.052
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0056 0.0219
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0024 0.0024
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0077 0.0674 0.0673
Echinococcus multilocularis RUN 0.0019 0.0056 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0281 0.028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0147
Echinococcus granulosus Solute carrier organic anion transporter family 0.0028 0.0147 0.0147
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0443 0.4611 1
Schistosoma mansoni follistatin 0.0019 0.0052 0.0052
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0106 0.0988 1
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0028 0.0147 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.052 0.052
Schistosoma mansoni voltage-gated cation channel 0.0077 0.0674 0.0673
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0024 0.0024
Loa Loa (eye worm) thymidylate synthase 0.0106 0.0988 0.0988
Schistosoma mansoni polycystin 1-related 0.0019 0.0056 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.052 0.052
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0056 0.0055
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0149 0.1453 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.052 0.052
Brugia malayi hypothetical protein 0.0028 0.0147 0.0147
Echinococcus multilocularis sterol regulatory element binding protein 0.0389 0.4027 0.4027
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0944 1 1
Echinococcus multilocularis agrin 0.0019 0.0052 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.052 0.052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.052 0.052
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0052 0.0052
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0944 1 1
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0052 0.0361
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.007 0.007
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0024 0.0024
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0052 0.0052
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0147 0.1276
Echinococcus multilocularis Niemann Pick C1 protein 0.0389 0.4027 0.4027
Toxoplasma gondii transporter, cation channel family protein 0.0016 0.0021 0.0144
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0077 0.0674 0.0673
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0281 0.028
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0052
Brugia malayi Cathepsin L-like precursor 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0147
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0281 0.028
Schistosoma mansoni loxhd1 0.0019 0.0056 0.0055
Schistosoma mansoni patched 1 0.0389 0.4027 0.4027
Echinococcus granulosus dna polymerase kappa 0.004 0.0281 0.028
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0077 0.0674 0.0673
Schistosoma mansoni rab6-interacting 0.0019 0.0056 0.0055
Leishmania major cathepsin L-like protease 0.0063 0.052 0.052
Onchocerca volvulus 0.0028 0.0147 0.1276
Mycobacterium tuberculosis Hypothetical protein 0.005 0.039 0.3947
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0077 0.0674 0.0673
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0106 0.0988 0.0987
Brugia malayi Cathepsin L-like precursor 0.0016 0.0024 0.0024
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0028 0.0147 0.0147
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.0313 0.3163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.052 0.052
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.039 0.039
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.007 0.0704
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0281 0.028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0147
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0149 0.1453 0.1452
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0056 0.0055
Loa Loa (eye worm) calcium channel 0.0077 0.0674 0.0674
Onchocerca volvulus 0.0019 0.0056 0.0325
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0176 0.0176
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0106 0.0988 1
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0024 0.0024
Brugia malayi Dihydrofolate reductase 0.0043 0.0313 0.0312
Brugia malayi Cathepsin L-like precursor 0.0016 0.0024 0.0024
Leishmania major cathepsin L-like protease 0.0016 0.0024 0.0024
Schistosoma mansoni dihydrofolate reductase 0.0043 0.0313 0.0312
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0147
Echinococcus granulosus voltage dependent calcium channel 0.0077 0.0674 0.0673
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0281 0.028
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0147 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0281 0.028
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0024 0.0024
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0052 0.0052
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.0313 0.0312
Brugia malayi Cathepsin L-like precursor 0.0016 0.0024 0.0024
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0944 1 1
Leishmania major cathepsin L-like protease 0.0016 0.0024 0.0024
Brugia malayi prostaglandin transporter 0.0028 0.0147 0.0147
Leishmania major cathepsin L-like protease 0.0016 0.0024 0.0024
Echinococcus multilocularis protein dispatched 1 0.0389 0.4027 0.4027
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0281 0.028
Leishmania major cathepsin L-like protease 0.0063 0.052 0.052
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0149 0.1453 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0149 0.1453 0.1452
Brugia malayi polk-prov protein 0.003 0.0176 0.0175
Leishmania major cathepsin L-like protease 0.0016 0.0024 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0056
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0028 0.0147 0.0147
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0944 1 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.0313 0.0033
Onchocerca volvulus 0.0106 0.0988 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0077 0.0674 0.0673
Toxoplasma gondii cathepsin CPL 0.0016 0.0024 0.0168
Brugia malayi hypothetical protein 0.0019 0.0056 0.0055
Echinococcus multilocularis sodium channel protein 0.0033 0.0198 0.0198
Echinococcus multilocularis protein patched 0.0389 0.4027 0.4027
Onchocerca volvulus 0.0028 0.0147 0.1276
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0052
Brugia malayi thymidylate synthase 0.0106 0.0988 0.0987
Echinococcus granulosus Protein patched homolog 1 0.0389 0.4027 0.4027
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0281 0.028
Loa Loa (eye worm) voltage-dependent calcium channel 0.0016 0.0021 0.0021
Brugia malayi hypothetical protein 0.005 0.039 0.039
Onchocerca volvulus 0.0028 0.0147 0.1276
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0056
Loa Loa (eye worm) fibroinase 0.0016 0.0024 0.0024
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.043 0.0429
Brugia malayi hypothetical protein 0.0019 0.0056 0.0055
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0077 0.0674 0.0673

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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