Detailed information for compound 1704236

Basic information

Technical information
  • TDR Targets ID: 1704236
  • Name: methyl (4S)-1-(2-methoxyethyl)-6-methyl-2-oxo -4-phenyl-3,4-dihydropyrimidine-5-carboxylate
  • MW: 304.341 | Formula: C16H20N2O4
  • H donors: 1 H acceptors: 2 LogP: 1.05 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN1C(=O)N[C@H](C(=C1C)C(=O)OC)c1ccccc1
  • InChi: 1S/C16H20N2O4/c1-11-13(15(19)22-3)14(12-7-5-4-6-8-12)17-16(20)18(11)9-10-21-2/h4-8,14H,9-10H2,1-3H3,(H,17,20)/t14-/m0/s1
  • InChiKey: DTOOQGAIGJDBNZ-AWEZNQCLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4S)-1-(2-methoxyethyl)-6-methyl-2-oxo-4-phenyl-3,4-dihydropyrimidine-5-carboxylic acid methyl ester
  • (4S)-2-keto-1-(2-methoxyethyl)-6-methyl-4-phenyl-3,4-dihydropyrimidine-5-carboxylic acid methyl ester
  • CMLDBU00003818
  • SMR000113199
  • MLS000438901

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0069 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0143 0.0155 0.0155
Loa Loa (eye worm) reprolysin 0.0223 0.0275 0.0275
Brugia malayi Glutamate receptor 2 precursor 0.0069 0.0045 0.0042
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.0275 0.0514
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.0143 0.0141
Echinococcus granulosus fibrillin 1 0.0158 0.0178 0.0234
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0197 0.0236 0.0236
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0092 0.008 0.0108
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0238 0.0297 0.4872
Loa Loa (eye worm) hypothetical protein 0.0114 0.0112 0.0111
Trypanosoma brucei prolyl endopeptidase 0.0137 0.0147 0.228
Brugia malayi hypothetical protein 0.0292 0.0379 0.0376
Echinococcus multilocularis MAM 0.0046 0.001 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0134 0.0142 0.0186
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.1425 0.2077 0.2818
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1453 0.3081
Mycobacterium ulcerans thioesterase 0.0072 0.005 0.1737
Toxoplasma gondii histone deacetylase SIR2 0.0066 0.004 0.1374
Giardia lamblia Tenascin-like 0.0158 0.0177 0.0502
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0066 0.004 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1453 0.3081
Echinococcus multilocularis protein jagged 2 0.0158 0.0177 0.0241
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0223 0.0275 1
Loa Loa (eye worm) integrin beta-2 0.6715 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.001 0.001
Schistosoma mansoni chromatin regulatory protein sir2 0.0445 0.0608 0.0795
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Toxoplasma gondii subtilisin SUB10 0.0223 0.0275 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0066 0.004 0.0491
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Loa Loa (eye worm) hypothetical protein 0.0066 0.004 0.0039
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0109 0.0105 0.3773
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Loa Loa (eye worm) proprotein convertase 2 0.1232 0.1786 0.1786
Schistosoma mansoni dihydroceramide desaturase 0.0092 0.008 0.0102
Echinococcus granulosus integrin beta 2 0.4959 0.7369 0.9669
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1453 0.3081
Schistosoma mansoni glutamate receptor NMDA 0.0087 0.0072 0.0092
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0158 0.0177 0.03
Loa Loa (eye worm) transcriptional regulator 0.0445 0.0608 0.0607
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0054 0.0023 0.0211
Brugia malayi angiogenesis inhibito 0.013 0.0137 0.0135
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0127 0.0131 0.4758
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0117 0.0117 0.0114
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0141 0.0152 0.0207
Brugia malayi SWIRM domain containing protein 0.0217 0.0266 0.0264
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0089 0.0075 0.2715
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0002 0.007
Onchocerca volvulus 0.0217 0.0266 0.9654
Schistosoma mansoni hypothetical protein 0.0114 0.0112 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.0332 0.0433
Mycobacterium ulcerans polyketide synthase Pks9 0.0054 0.0023 0.0756
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0084 0.0067 0.2368
Schistosoma mansoni hypothetical protein 0.0046 0.001 0.001
Toxoplasma gondii hypothetical protein 0.0158 0.0177 0.6414
Onchocerca volvulus 0.0158 0.0177 0.6311
Onchocerca volvulus 0.0151 0.0167 0.594
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0137 0.0147 0.019
Brugia malayi protein kinase C II. 0.0087 0.0072 0.007
Schistosoma mansoni integrin alpha-ps 0.0423 0.0575 0.0752
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0093 0.008 0.2852
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Brugia malayi Protein kinase domain containing protein 0.0046 0.001 0.0008
Mycobacterium ulcerans thioesterase TesA 0.0072 0.005 0.1737
Loa Loa (eye worm) hypothetical protein 0.0907 0.13 0.1299
Loa Loa (eye worm) hypothetical protein 0.2 0.2937 0.2937
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.0275 0.0514
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0223 0.0275 1
Schistosoma mansoni hypothetical protein 0.0062 0.0035 0.0043
Brugia malayi prolyl oligopeptidase family protein 0.0137 0.0147 0.0144
Giardia lamblia High cysteine protein 0.0158 0.0177 0.0502
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0048 0.0014 0.0018
Schistosoma mansoni integrin alpha-ps 0.0686 0.0968 0.1268
Brugia malayi hypothetical protein 0.103 0.1484 0.1482
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0223 0.0275 1
Echinococcus granulosus prolyl endopeptidase 0.0137 0.0147 0.0192
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0668 0.0942 0.1279
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0223 0.0275 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.0275 0.0514
Loa Loa (eye worm) transcriptional regulator 0.0066 0.004 0.0039
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0007 0.0177
Giardia lamblia hypothetical protein 0.0158 0.0177 0.0502
Loa Loa (eye worm) hypothetical protein 0.0046 0.001 0.0009
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0048 0.0014 0.0018
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0223 0.0275 1
Echinococcus granulosus nmda type glutamate receptor 0.0141 0.0152 0.02
Brugia malayi AMP-binding enzyme family protein 0.0081 0.0063 0.0061
Echinococcus granulosus glutamate receptor subunit protein glur 0.0048 0.0014 0.0018
Toxoplasma gondii subtilisin SUB2 0.0223 0.0275 1
Schistosoma mansoni furin-1 (S08 family) 0.2223 0.3271 0.4291
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0261 0.0332 0.0331
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0054 0.0023 0.0761
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1044 0.1506 0.1505
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Loa Loa (eye worm) glutamate receptor 1 0.0069 0.0045 0.0044
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0067 0.0041 0.1438
Echinococcus multilocularis glutamate receptor 2 0.0069 0.0045 0.006
Loa Loa (eye worm) hypothetical protein 0.0066 0.004 0.0039
Echinococcus granulosus protein kinase c epsilon type 0.0087 0.0072 0.0094
Toxoplasma gondii subtilisin SUB1 0.0223 0.0275 1
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0223 0.0275 0.0361
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Loa Loa (eye worm) hypothetical protein 0.0158 0.0177 0.0177
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0109 0.0105 0.0143
Loa Loa (eye worm) hypothetical protein 0.103 0.1484 0.1483
Onchocerca volvulus Fatty acid synthase homolog 0.0156 0.0176 0.6244
Toxoplasma gondii subtilisin SUB9 0.0223 0.0275 1
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0109 0.0105 0.3773
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0089 0.0075 0.2663
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0445 0.0608 1
Mycobacterium ulcerans Sir2-like regulatory protein 0.0066 0.004 0.1374
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0066 0.004 0.0491
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0054 0.0023 0.0826
Echinococcus granulosus lysine specific histone demethylase 1A 0.02 0.0241 0.0316
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0054 0.0023 0.0343
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0338 0.0447 0.0606
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0445 0.0608 0.1239
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.3127 0.4625 0.6276
Echinococcus multilocularis 0.4118 0.611 0.8291
Echinococcus granulosus chromatin regulatory protein sir2 0.0445 0.0608 0.0798
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0109 0.0105 0.3773
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0223 0.0275 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0084 0.0067 0.2437
Toxoplasma gondii subtilisin SUB11 0.0223 0.0275 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0177 0.0177
Brugia malayi neuroendocrine convertase 1 precursor 0.3232 0.4783 0.4782
Giardia lamblia Neurogenic locus notch-like protein 0.0158 0.0177 0.0502
Toxoplasma gondii histone deacetylase SIR2-like 0.0066 0.004 0.1374
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0109 0.0105 0.0143
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.004 0.0049
Schistosoma mansoni chromatin regulatory protein sir2 0.0445 0.0608 0.0795
Giardia lamblia High cysteine protein 0.0158 0.0177 0.0502
Loa Loa (eye worm) sirtuin 4 0.0066 0.004 0.0039
Echinococcus multilocularis integrin beta 2 0.4959 0.7369 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0084 0.0067 0.2368
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0089 0.0075 0.2715
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1453 0.3081
Echinococcus granulosus serine:threonine protein kinase N2 0.0071 0.0048 0.0063
Loa Loa (eye worm) hypothetical protein 0.5127 0.7621 0.7621
Loa Loa (eye worm) hypothetical protein 0.0639 0.0898 0.0898
Loa Loa (eye worm) hypothetical protein 0.02 0.0241 0.024
Brugia malayi hypothetical protein 0.0046 0.001 0.0008
Toxoplasma gondii type I fatty acid synthase, putative 0.0062 0.0034 0.1159
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Echinococcus multilocularis integrin alpha ps 0.0686 0.0968 0.1314
Loa Loa (eye worm) apoptosis regulator protein 0.0114 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.0135 0.0143 0.0142
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0109 0.0105 0.1701
Echinococcus multilocularis 0.0041 0.0002 0.0003
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0087 0.0072 0.0095
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0072 0.005 0.1737
Trypanosoma brucei subtilisin peptidase 0.0223 0.0275 0.4433
Mycobacterium leprae Probable polyketide synthase Pks1 0.0089 0.0075 0.2663
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0109 0.0105 0.3773
Echinococcus multilocularis integrin alpha 3 0.0967 0.139 0.1887
Echinococcus multilocularis GPCR, family 2 0.0062 0.0035 0.0047
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0292 0.0379 0.0494
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Echinococcus granulosus membrane bound transcription factor site 1 0.0223 0.0275 0.0361
Schistosoma mansoni hypothetical protein 0.0329 0.0434 0.0566
Schistosoma mansoni hypothetical protein 0.0135 0.0143 0.0185
Trichomonas vaginalis hypothetical protein 0.1009 0.1453 0.3081
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0002 0.007
Brugia malayi proprotein convertase 2 0.3232 0.4783 0.4782
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0054 0.0023 0.0343
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0092 0.008 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.0275 0.0514
Loa Loa (eye worm) hypothetical protein 0.013 0.0137 0.0136
Schistosoma mansoni glutamate receptor AMPA 0.0069 0.0045 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1453 0.3081
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0046 0.001 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1453 0.3081
Plasmodium vivax subtilisin-like serine protease, putative 0.0223 0.0275 1
Brugia malayi Stress-activated protein kinase jnk-1 0.0261 0.0332 0.033
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.3127 0.4625 0.6069
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0114 0.0112 0.011
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0114 0.0112 0.0152
Echinococcus granulosus integrin alpha 3 0.0967 0.139 0.1824
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0067 0.0041 0.1438
Schistosoma mansoni hypothetical protein 0.0114 0.0112 0.0144
Mycobacterium ulcerans Type I modular polyketide synthase 0.0084 0.0067 0.2368
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0072 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1232 0.1786 0.381
Echinococcus multilocularis epidermal growth factor receptor 0.0196 0.0235 0.0319
Brugia malayi endoprotease bli-4 precursor 0.5127 0.7621 0.7621
Brugia malayi EGF-like domain containing protein 0.0158 0.0177 0.0175
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0066 0.004 0.1374
Chlamydia trachomatis glutamine binding protein 0.0093 0.008 0.756
Mycobacterium ulcerans polyketide synthase Pks13 0.0127 0.0131 0.4721
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1453 0.3081
Echinococcus multilocularis Furin 1 0.1232 0.1786 0.2424
Loa Loa (eye worm) glutamate receptor 2 0.0069 0.0045 0.0044
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0114 0.0112 0.0147
Brugia malayi NAD-dependent deacetylase SIRT1 0.0066 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0158 0.0177 0.0177
Schistosoma mansoni chromatin regulatory protein sir2 0.0445 0.0608 0.0795
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0109 0.0105 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0084 0.0067 0.2437
Brugia malayi EGF-like domain containing protein 0.0158 0.0177 0.0175
Brugia malayi Calcitonin receptor-like protein seb-1 0.0197 0.0236 0.0234
Mycobacterium ulcerans polyketide synthase 0.0089 0.0075 0.2663
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0048 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0046 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0423 0.0575 0.0574
Schistosoma mansoni hypothetical protein 0.0062 0.0035 0.0043
Schistosoma mansoni memapsin-2 (A01 family) 0.0841 0.1201 0.1574
Schistosoma mansoni hypothetical protein 0.0048 0.0014 0.0015
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0066 0.004 0.0052
Echinococcus multilocularis glutamate receptor 2 0.0087 0.0072 0.0098
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0066 0.004 0.0619
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0048 0.0014 0.0018
Trypanosoma brucei prolyl oligopeptidase, putative 0.0054 0.0023 0.0211
Brugia malayi Furin-like cysteine rich region family protein 0.0196 0.0235 0.0233
Loa Loa (eye worm) hypothetical protein 0.0395 0.0532 0.0532
Schistosoma mansoni glutamate receptor kainate 0.0069 0.0045 0.0056
Echinococcus multilocularis NMDA receptor 0.0048 0.0014 0.0018
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0066 0.004 0.0052
Mycobacterium ulcerans NAD-dependent deacetylase 0.0066 0.004 0.1374
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1232 0.1786 0.381
Brugia malayi transcriptional regulator, Sir2 family protein 0.0066 0.004 0.0038
Schistosoma mansoni integrin beta subunit 0.3929 0.5827 0.7645
Echinococcus multilocularis protein kinase c epsilon type 0.0087 0.0072 0.0097
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0087 0.0072 0.0098
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1009 0.1453 0.3081
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0035 0.0033
Echinococcus multilocularis fibrillin 2 0.0158 0.0177 0.0241
Loa Loa (eye worm) hypothetical protein 0.0803 0.1144 0.1143
Loa Loa (eye worm) hypothetical protein 0.0041 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0041 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0445 0.0608 0.0825
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0223 0.0275 0.0273
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0445 0.0608 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0238 0.0297 0.4872
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0054 0.0023 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1453 0.3081
Plasmodium vivax subtilisin-like protease 1 0.0223 0.0275 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0087 0.0072 0.0098
Onchocerca volvulus 0.0081 0.0063 0.1993
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0114 0.0112 0.0144
Loa Loa (eye worm) hypothetical protein 0.0223 0.0275 0.0275
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0062 0.0034 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1232 0.1786 0.381
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0062 0.0035 0.1252
Plasmodium vivax hypothetical protein, conserved 0.0066 0.004 0.1374
Loa Loa (eye worm) hypothetical protein 0.0158 0.0177 0.0177
Loa Loa (eye worm) endoprotease bli-4 0.5127 0.7621 0.7621
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0109 0.0105 0.0135
Mycobacterium ulcerans polyketide synthase 0.0084 0.0067 0.2368
Schistosoma mansoni glutamate receptor kainate 0.0069 0.0045 0.0056
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.5127 0.7621 1
Brugia malayi EGF-like domain containing protein 0.0158 0.0177 0.0175
Loa Loa (eye worm) hypothetical protein 0.0062 0.0035 0.0034
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0054 0.0023 0.0756
Loa Loa (eye worm) hypothetical protein 0.0046 0.001 0.0009
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0062 0.0034 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Brugia malayi celfurPC protein 0.4118 0.611 0.6109
Mycobacterium ulcerans Type I modular polyketide synthase 0.0084 0.0067 0.2368
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0087 0.0072 0.0095
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0084 0.0067 0.2421
Brugia malayi Kelch motif family protein 0.1044 0.1506 0.1504
Echinococcus granulosus GPCR family 2 0.0062 0.0035 0.0045
Echinococcus granulosus disintegrin and metalloproteinase 0.0092 0.008 0.0105
Brugia malayi Disintegrin family protein 0.0092 0.008 0.0078
Leishmania major subtilisin-like serine peptidase 0.0223 0.0275 0.4508
Toxoplasma gondii subtilisin SUB8 0.0223 0.0275 1
Schistosoma mansoni protein kinase 0.0134 0.0142 0.0183
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0084 0.0067 0.2368
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0084 0.0067 0.2421
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0084 0.0067 0.2421
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0092 0.008 0.0079
Trypanosoma cruzi oligopeptidase b 0.0054 0.0023 0.0343
Echinococcus multilocularis integrin alpha ps 0.0752 0.1067 0.1448
Giardia lamblia High cysteine membrane protein Group 2 0.1895 0.278 1
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0238 0.0297 0.4802
Echinococcus granulosus c-Jun N-terminal kinases 0.0261 0.0332 0.0435
Schistosoma mansoni hypothetical protein 0.0114 0.0112 0.0144
Echinococcus granulosus epidermal growth factor receptor 0.0196 0.0235 0.0308
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0049 0.0015 0.0544
Schistosoma mansoni tyrosine kinase 0.0196 0.0235 0.0306
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.1425 0.2077 0.2725
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0137 0.0147 0.2384
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0068 0.0043 0.156
Loa Loa (eye worm) hypothetical protein 0.0996 0.1433 0.1432
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0081 0.0063 0.0062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3127 0.4625 1
Echinococcus granulosus integrin alpha ps 0.0329 0.0434 0.0569
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0109 0.0105 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0054 0.0023 0.0756
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0803 0.1144 0.1142
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0223 0.0275 0.0273
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0223 0.0275 0.0361
Onchocerca volvulus 0.0054 0.0022 0.0446
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0066 0.004 0.0054
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0668 0.0942 0.1236
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0123 0.0125 0.4539
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0137 0.0147 0.019
Schistosoma mansoni integrin alpha 0.1324 0.1925 0.2524
Brugia malayi Integrin alpha pat-2 precursor 0.1324 0.1925 0.1923
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0109 0.0105 0.5
Schistosoma mansoni apoptosis regulator bax 0.0114 0.0112 0.0144
Toxoplasma gondii prolyl endopeptidase 0.0137 0.0147 0.5289
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0161 0.0183 0.0181
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3127 0.4625 1
Plasmodium falciparum subtilisin-like protease 1 0.0223 0.0275 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0445 0.0608 1
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0223 0.0275 0.4508
Loa Loa (eye worm) transcriptional regulator 0.0066 0.004 0.0039
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0048 0.0014 0.0018
Leishmania major silent information regulator 2, putative 0.0445 0.0608 1
Giardia lamblia Neurogenic locus Notch protein precursor 0.0158 0.0177 0.0502
Brugia malayi Glutamate receptor 1 precursor 0.0069 0.0045 0.0042
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0223 0.0275 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0056 0.0026 0.0859
Echinococcus multilocularis lysine specific histone demethylase 1A 0.02 0.0241 0.0327
Echinococcus granulosus fibrillin 2 0.0158 0.0177 0.0233
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0002 0.0003
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0087 0.0072 0.0071
Echinococcus granulosus integrin alpha ps 0.0752 0.1067 0.14
Echinococcus multilocularis serine:threonine protein kinase N2 0.008 0.0061 0.0082
Mycobacterium leprae Polyketide synthase Pks13 0.0127 0.0131 0.4721
Brugia malayi Reprolysin 0.0131 0.0137 0.0135
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Giardia lamblia Tenascin-X 0.0158 0.0177 0.0502
Leishmania major oligopeptidase b 0.0054 0.0023 0.0343
Entamoeba histolytica hypothetical protein, conserved 0.0066 0.004 0.0491
Loa Loa (eye worm) TK/ALK protein kinase 0.0046 0.001 0.0009
Loa Loa (eye worm) metalloprotease 0.0062 0.0034 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1453 0.3081
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0134 0.0142 0.0193
Echinococcus multilocularis disintegrin and metalloproteinase 0.0092 0.008 0.0108
Trypanosoma brucei oligopeptidase b 0.0054 0.0023 0.0211
Trypanosoma cruzi subtilisin peptidase 0.0223 0.0275 0.4508
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1232 0.1786 0.381
Brugia malayi ADAM-TS Spacer 1 family protein 0.013 0.0137 0.0135
Loa Loa (eye worm) hypothetical protein 0.0223 0.0275 0.0275
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1009 0.1453 0.3081
Schistosoma mansoni glutamate receptor AMPA 0.0069 0.0045 0.0056
Schistosoma mansoni hypothetical protein 0.1009 0.1453 0.1904
Echinococcus multilocularis prolyl endopeptidase 0.0137 0.0147 0.0199
Loa Loa (eye worm) subtilase 0.0223 0.0275 0.0275
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0445 0.0608 1
Loa Loa (eye worm) angiogenesis inhibito 0.0062 0.0034 0.0033
Toxoplasma gondii subtilisin SUB4 0.0223 0.0275 1
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0048 0.0014 0.0018
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0223 0.0275 0.0359
Loa Loa (eye worm) hypothetical protein 0.0137 0.0147 0.0146
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0089 0.0075 0.2663
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0109 0.0105 0.0105
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1009 0.1453 0.3081
Schistosoma mansoni site-1 peptidase (S08 family) 0.0223 0.0275 0.0358
Loa Loa (eye worm) hypothetical protein 0.0217 0.0266 0.0265
Mycobacterium tuberculosis Probable thioesterase TesA 0.0072 0.005 0.1795
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0089 0.0075 0.2663
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0066 0.004 0.0619
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0066 0.004 0.0054
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0109 0.0105 0.3773
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0445 0.0608 1
Echinococcus granulosus MAM 0.0046 0.001 0.0013
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0445 0.0608 0.1239
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1453 0.3081
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0109 0.0105 0.1701
Trichomonas vaginalis hypothetical protein 0.0158 0.0177 0.03
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0109 0.0105 0.3816
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0445 0.0608 0.0798
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0223 0.0275 0.0358
Loa Loa (eye worm) integrin alpha pat-2 0.1837 0.2692 0.2692
Echinococcus granulosus Furin 1 0.1232 0.1786 0.2344
Echinococcus multilocularis adam 0.0449 0.0615 0.0834
Echinococcus multilocularis integrin alpha ps 0.0329 0.0434 0.0588
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0093 0.008 0.2902
Giardia lamblia Tenascin precursor 0.0158 0.0177 0.0502
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0084 0.0067 0.0065
Giardia lamblia Hypothetical protein 0.0445 0.0608 0.2074
Echinococcus granulosus adam 0.0449 0.0615 0.0806
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0117 0.0117 0.0116
Brugia malayi hypothetical protein 0.0046 0.001 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.1453 0.3081
Loa Loa (eye worm) fatty acid synthase 0.0086 0.007 0.0069
Echinococcus multilocularis neuroendocrine convertase 2 0.3232 0.4783 0.649
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1232 0.1786 0.381
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0127 0.0131 0.4758
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.004 0.0049
Plasmodium vivax subtilisin-like protease 2, putative 0.0223 0.0275 1
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0261 0.0332 0.045
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0087 0.0072 0.0098
Brugia malayi ADAMTS-like protease 0.013 0.0137 0.0135
Schistosoma mansoni Lysine-specific histone demethylase 1 0.02 0.0241 0.0313
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0223 0.0275 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0137 0.0147 0.5153
Brugia malayi metalloprotease 0.0062 0.0034 0.0032
Toxoplasma gondii subtilisin SUB7 0.0223 0.0275 1
Trypanosoma cruzi oligopeptidase b 0.0054 0.0023 0.0343
Trypanosoma cruzi prolyl endopeptidase 0.0137 0.0147 0.2384
Mycobacterium ulcerans Type I modular polyketide synthase 0.0084 0.0067 0.2368
Mycobacterium tuberculosis Probable peptidase 0.0054 0.0023 0.0826
Toxoplasma gondii subtilisin SUB12 0.0223 0.0275 1
Schistosoma mansoni hypothetical protein 0.0062 0.0035 0.0043
Brugia malayi transcriptional regulator, Sir2 family protein 0.0445 0.0608 0.0606
Leishmania major sir2-family protein-like protein 0.0066 0.004 0.0619
Loa Loa (eye worm) hypothetical protein 0.0046 0.001 0.0009
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0089 0.0075 0.2663
Schistosoma mansoni protein kinase 0.0134 0.0142 0.0183
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0223 0.0275 0.0359
Echinococcus granulosus adam 17 protease 0.0092 0.008 0.0105
Plasmodium vivax NAD-dependent deacetylase, putative 0.0066 0.004 0.1374
Giardia lamblia Tenascin-37 0.0158 0.0177 0.0502
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0048 0.063
Echinococcus multilocularis fibrillin 1 0.0158 0.0178 0.0242
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0109 0.0105 0.1587
Toxoplasma gondii subtilisin SUB6 0.0223 0.0275 1
Mycobacterium leprae Possible secreted protease 0.0223 0.0275 1
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0109 0.0105 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.0275 0.0514
Plasmodium falciparum subtilisin-like protease 3 0.0223 0.0275 1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0093 0.008 0.756
Echinococcus granulosus neuroendocrine convertase 2 0.3232 0.4783 0.6276
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0087 0.0072 0.0098
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0035 0.0033
Loa Loa (eye worm) TK/EGFR protein kinase 0.0196 0.0235 0.0234
Echinococcus multilocularis nmda type glutamate receptor 0.0141 0.0152 0.0207
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0046 0.001 0.0135
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0087 0.0072 0.0095
Echinococcus multilocularis chromatin regulatory protein sir2 0.0445 0.0608 0.0825
Schistosoma mansoni hypothetical protein 0.0062 0.0035 0.0043
Echinococcus granulosus furin 0.5127 0.7621 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0066 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.013 0.0137 0.0136
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0223 0.0275 0.0514
Schistosoma mansoni protein kinase 0.0134 0.0142 0.0183
Toxoplasma gondii subtilisin SUB5 0.0223 0.0275 1
Echinococcus granulosus glutamate receptor 2 0.0087 0.0072 0.0095
Schistosoma mansoni glutamate receptor kainate 0.0069 0.0045 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1232 0.1786 0.381
Brugia malayi amine oxidase, flavin-containing family protein 0.0058 0.0027 0.0025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0035 0.0045
Brugia malayi EGF-like domain containing protein 0.0158 0.0177 0.0175
Schistosoma mansoni hypothetical protein 0.0046 0.001 0.001
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0066 0.004 0.0054
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0223 0.0275 0.0374
Echinococcus multilocularis membrane bound transcription factor site 1 0.0223 0.0275 0.0373
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0109 0.0105 0.0103
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0223 0.0275 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0027 0.0027
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0067 0.0041 0.1438
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0223 0.0275 1
Brugia malayi Subtilase family protein 0.0223 0.0275 0.0273
Schistosoma mansoni ATP-binding cassette transporter 0.0072 0.0049 0.0061
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0066 0.004 0.0619
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1232 0.1786 0.2342
Toxoplasma gondii type I fatty acid synthase, putative 0.0089 0.0075 0.2663
Loa Loa (eye worm) hypothetical protein 0.02 0.0241 0.024
Echinococcus granulosus glutamate NMDA receptor subunit 0.0338 0.0447 0.0586
Schistosoma mansoni site-1 peptidase (S08 family) 0.0223 0.0275 0.0358
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0066 0.004 0.0052
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0087 0.0072 0.0095
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0035 0.0034
Onchocerca volvulus 0.0223 0.0275 1
Plasmodium falciparum subtilisin-like protease 2 0.0223 0.0275 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0035 0.0047
Giardia lamblia Furin precursor putative serine protease 0.1009 0.1453 0.5156
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0907 0.13 0.1298
Schistosoma mansoni glutamate receptor NMDA 0.0338 0.0447 0.0584
Trypanosoma brucei SIR2-like protein 4, putative 0.0066 0.004 0.0491
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0054 0.0023 0.0761
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0223 0.0275 0.0373
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0066 0.004 0.1434
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0089 0.0075 0.2715
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0066 0.004 0.1374
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0081 0.0063 0.2272

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0032 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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