Detailed information for compound 1704265

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 508.523 | Formula: C26H28N4O7
  • H donors: 2 H acceptors: 4 LogP: 2.12 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN(c1c(=O)[nH]c(=O)n(c1N)Cc1ccccc1)C(=O)COC(=O)/C=C/c1ccc(c(c1)OC)OC
  • InChi: 1S/C26H28N4O7/c1-4-29(23-24(27)30(26(34)28-25(23)33)15-18-8-6-5-7-9-18)21(31)16-37-22(32)13-11-17-10-12-19(35-2)20(14-17)36-3/h5-14H,4,15-16,27H2,1-3H3,(H,28,33,34)/b13-11+
  • InChiKey: UCAAZEXJSWXSNY-ACCUITESSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0049 0.1343
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0743
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0068
Loa Loa (eye worm) hypothetical protein 0.0085 0.0242 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0058 0.0269
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0044 0.0107 0.0375
Loa Loa (eye worm) hypothetical protein 0.0504 0.1654 0.1651
Trypanosoma brucei unspecified product 0.004 0.0091 0.0743
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0024 0.002
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0024 0.002
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0049 0.0867
Trichomonas vaginalis chromobox protein, putative 0.0075 0.021 0.1199
Brugia malayi SWIRM domain containing protein 0.004 0.0093 0.0089
Echinococcus granulosus axis inhibition protein axin 0.002 0.0024 0.002
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0022 0.0031 0.0027
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0048 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0151 0.0466 0.0463
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0049 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0137 0.0419 0.0419
Brugia malayi Muscleblind-like protein 0.1096 0.3648 0.3645
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0024 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0107 0.0375
Mycobacterium ulcerans lipase LipD 0.0037 0.0083 0.0248
Entamoeba histolytica hypothetical protein 0.0024 0.0037 0.0294
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0083 0.0424
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0073 0.0069
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0049 0.0339
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0112 0.0942
Echinococcus multilocularis muscleblind protein 1 0.1096 0.3648 0.3645
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0024 0.002
Schistosoma mansoni axis inhibition protein axin 0.002 0.0024 0.0024
Loa Loa (eye worm) TAR-binding protein 0.0137 0.0419 0.0415
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0024 0.002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0091 0.0087
Onchocerca volvulus 0.0044 0.0107 0.0623
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0049 0.0045
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0065 0.092
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0151 0.0466 0.2318
Mycobacterium ulcerans acyl-CoA synthetase 0.0151 0.0466 0.2318
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0743
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0107 0.0897
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0323 0.0319
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0112 0.0942
Schistosoma mansoni hypothetical protein 0.0014 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0519 0.1706 0.1706
Echinococcus granulosus expressed protein 0.0033 0.0068 0.0064
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0044 0.0107 0.0405
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0083 0.0669
Loa Loa (eye worm) hypothetical protein 0.0113 0.0338 0.0334
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0044 0.0107 0.0405
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0107 0.0569
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.0005 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0091 0.0743
Schistosoma mansoni amine oxidase 0.004 0.0093 0.0093
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0083 0.0424
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0092 0.0268 0.5505
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.021 0.0206
Loa Loa (eye worm) hypothetical protein 0.0074 0.0207 0.0203
Mycobacterium ulcerans hypothetical protein 0.0037 0.0083 0.0248
Onchocerca volvulus 0.0504 0.1654 1
Schistosoma mansoni chromobox protein 0.0075 0.021 0.021
Loa Loa (eye worm) RNA binding protein 0.0137 0.0419 0.0415
Trypanosoma brucei unspecified product 0.0027 0.0049 0.0344
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0065 0.0494
Schistosoma mansoni amine oxidase 0.004 0.0093 0.0093
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.023 0.0732 0.0728
Plasmodium vivax hypothetical protein, conserved 0.004 0.0093 0.2676
Plasmodium vivax hypothetical protein, conserved 0.004 0.0093 0.2676
Schistosoma mansoni acetylcholinesterase 0.0504 0.1654 0.1654
Echinococcus granulosus tar DNA binding protein 0.0137 0.0419 0.0415
Loa Loa (eye worm) hypothetical protein 0.0504 0.1654 0.1651
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0107 0.0103
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0151 0.0466 1
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0091 0.0289
Echinococcus granulosus geminin 0.0519 0.1706 0.1702
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0091 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0429 0.0425
Brugia malayi hypothetical protein 0.0018 0.0016 0.0012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.0419 0.0415
Giardia lamblia DINP protein human, muc B family 0.004 0.0091 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0089
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0504 0.1654 0.1654
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0049 0.1343
Echinococcus multilocularis neuroligin 0.0504 0.1654 0.1651
Mycobacterium tuberculosis Conserved protein 0.0037 0.0083 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0066
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2984 1 1
Brugia malayi beta-lactamase family protein 0.0037 0.0083 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0024
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0504 0.1654 0.1651
Loa Loa (eye worm) hypothetical protein 0.0113 0.0338 0.0334
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0107 0.0897
Brugia malayi hypothetical protein 0.0504 0.1654 0.1651
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0079
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0107 0.0375
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0065 0.0581
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0022 0.0031 0.0027
Echinococcus multilocularis GPCR, family 2 0.0034 0.0073 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0151 0.0466 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0743
Loa Loa (eye worm) hypothetical protein 0.0113 0.0338 0.0334
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0024 0.002
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0242 0.0238
Onchocerca volvulus 0.0085 0.0242 0.1441
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0037 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0049 0.0339
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0037 0.0998
Loa Loa (eye worm) hypothetical protein 0.0092 0.0268 0.0264
Mycobacterium tuberculosis Conserved protein 0.0037 0.0083 0.0267
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0044 0.0107 0.1619
Schistosoma mansoni chromobox protein 0.0075 0.021 0.021
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0113 0.0338 0.1623
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0079
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0044 0.0107 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0068
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0024 0.0024
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0019 0.0446
Brugia malayi CXXC zinc finger family protein 0.0088 0.0255 0.0251
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0083 0.0267
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0022 0.0031 0.0027
Loa Loa (eye worm) hypothetical protein 0.1096 0.3648 0.3645
Onchocerca volvulus 0.0037 0.0083 0.048
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0024 0.002
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0024 0.002
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0037 0.0644
Onchocerca volvulus 0.0504 0.1654 1
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0022 0.0031 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0743
Leishmania major hypothetical protein, conserved 0.0037 0.0083 0.0754
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0024 0.002
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0044 0.0107 0.1619
Loa Loa (eye worm) acetylcholinesterase 1 0.2984 1 1
Echinococcus granulosus BC026374 protein S09 family 0.0504 0.1654 0.1651
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0073 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0743
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0091 0.0087
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0092 0.0268 0.5505
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0024 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0066
Brugia malayi Protein kinase domain containing protein 0.0018 0.0019 0.0015
Brugia malayi amine oxidase, flavin-containing family protein 0.004 0.0093 0.0089
Onchocerca volvulus 0.0504 0.1654 1
Trichomonas vaginalis esterase, putative 0.0037 0.0083 0.0424
Onchocerca volvulus 0.0014 0.0005 0.0007
Schistosoma mansoni DNA polymerase eta 0.004 0.0091 0.0091
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0016 0.0012
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0107 0.0103
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0083 0.2371
Loa Loa (eye worm) beta-lactamase 0.0037 0.0083 0.0079
Trichomonas vaginalis rotamase, putative 0.0032 0.0065 0.0314
Brugia malayi TAR-binding protein 0.0137 0.0419 0.0415
Brugia malayi MH2 domain containing protein 0.0131 0.04 0.0396
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0107 0.0375
Leishmania major 4-coumarate:coa ligase-like protein 0.0151 0.0466 0.4405
Mycobacterium ulcerans monoamine oxidase 0.004 0.0093 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0743
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0091 0.0743
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0073 0.0069
Leishmania major 4-coumarate:coa ligase-like protein 0.0151 0.0466 0.4405
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0044 0.0107 0.0375
Echinococcus multilocularis para nitrobenzyl esterase 0.0504 0.1654 0.1651
Loa Loa (eye worm) hypothetical protein 0.0044 0.0107 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0137 0.0419 0.0419
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0017 0.0014 0.0091
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0017 0.0014 0.001
Leishmania major UDP-galactopyranose mutase 0.004 0.0093 0.085
Onchocerca volvulus 0.0098 0.0287 0.1713
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0099 0.0522
Schistosoma mansoni axis inhibition protein axin 0.002 0.0024 0.0024
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0049 0.1343
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0255 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0099 0.0522
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0091 0.0312
Echinococcus multilocularis BC026374 protein (S09 family) 0.0504 0.1654 0.1651
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0112 0.0942
Toxoplasma gondii hypothetical protein 0.0053 0.0134 0.2517
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0151 0.0466 0.2318
Brugia malayi hypothetical protein 0.002 0.0024 0.002
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.004 0.0093 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0066 0.0321
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.011 0.0642
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0533 0.1752 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.0086 0.0284
Trichomonas vaginalis spcc417.12 protein, putative 0.0504 0.1654 1
Brugia malayi hypothetical protein 0.002 0.0024 0.002
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0024 0.002
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0044 0.0107 0.0405
Loa Loa (eye worm) hypothetical protein 0.0109 0.0323 0.0319
Schistosoma mansoni regulator of G protein signaling 0.002 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0089
Brugia malayi Kringle domain containing protein 0.0018 0.0019 0.0015
Echinococcus multilocularis dna polymerase eta 0.004 0.0091 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.002
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0019 0.0288
Mycobacterium ulcerans dehydrogenase 0.004 0.0093 0.0302
Loa Loa (eye worm) carboxylesterase 0.0504 0.1654 0.1651
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0083 0.0669
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.002
Toxoplasma gondii histone lysine-specific demethylase 0.004 0.0093 0.1727
Onchocerca volvulus 0.0044 0.0107 0.0623
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0083 0.0669
Brugia malayi Carboxylesterase family protein 0.0504 0.1654 0.1651
Echinococcus granulosus cpg binding protein 0.0093 0.0272 0.0268
Trichomonas vaginalis chromobox protein, putative 0.0045 0.011 0.0587
Echinococcus multilocularis acetylcholinesterase 0.2984 1 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0068
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0016 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0031 0.0031
Echinococcus multilocularis tar DNA binding protein 0.0137 0.0419 0.0415
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0107 0.0103
Echinococcus granulosus para nitrobenzyl esterase 0.0504 0.1654 0.1651
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0066
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0037 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0091 0.0087
Echinococcus granulosus acetylcholinesterase 0.2984 1 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0024 0.002
Brugia malayi hypothetical protein 0.004 0.0093 0.0089
Loa Loa (eye worm) hypothetical protein 0.0151 0.0466 0.0463
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0091 0.0827
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0107 0.0317 0.163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0107 0.0317 0.163
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0113 0.0338 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0064
Echinococcus granulosus lysine specific histone demethylase 1A 0.004 0.0093 0.0089
Echinococcus granulosus chromobox protein 1 0.0075 0.021 0.0206
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0107 0.0103
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0044 0.0107 0.0375
Schistosoma mansoni hypothetical protein 0.0244 0.0779 0.0779
Leishmania major 4-coumarate:coa ligase-like protein 0.0151 0.0466 0.4405
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0079
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0107 0.0405
Loa Loa (eye worm) hypothetical protein 0.0504 0.1654 0.1651
Brugia malayi Carboxylesterase family protein 0.0504 0.1654 0.1651
Loa Loa (eye worm) hypothetical protein 0.0042 0.0099 0.0095
Echinococcus multilocularis dna polymerase kappa 0.004 0.0091 0.0087
Schistosoma mansoni rotamase 0.0033 0.0068 0.0068
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0068 0.0064
Onchocerca volvulus 0.0504 0.1654 1
Brugia malayi PXA domain containing protein 0.002 0.0024 0.002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0035 0.013
Trichomonas vaginalis helicase, putative 0.002 0.0025 0.0068
Loa Loa (eye worm) hypothetical protein 0.0113 0.0338 0.0334
Entamoeba histolytica acyl-CoA synthetase, putative 0.0151 0.0466 1
Leishmania major DNA polymerase kappa, putative 0.004 0.0091 0.0827
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0083 0.0248
Schistosoma mansoni hypothetical protein 0.0018 0.0019 0.0019
Toxoplasma gondii ABC1 family protein 0.0037 0.0083 0.153
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0068 0.0329
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0107 0.0103
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0073 0.0069
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0044 0.0107 0.0405
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0022 0.0031 0.0027
Loa Loa (eye worm) hypothetical protein 0.0113 0.0338 0.0334
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0207 0.0203
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0024 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0743
Plasmodium vivax acetyl-CoA synthetase, putative 0.0044 0.0107 0.308
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0037 0.0317
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0079
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0019 0.0015
Echinococcus granulosus neuroligin 0.0504 0.1654 0.1651
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0107 0.0405
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0073 0.0069
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.04 0.0396
Schistosoma mansoni hypothetical protein 0.1259 0.4196 0.4196
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0091 0.0471
Onchocerca volvulus 0.0018 0.0019 0.009
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0022 0.0031 0.0027
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0049 0.0339
Entamoeba histolytica acyl-CoA synthetase, putative 0.0151 0.0466 1
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0091 0.0289
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0504 0.1654 0.1651
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0049 0.0344
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0743
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0107 0.0375
Schistosoma mansoni regulator of G protein signaling 0.002 0.0024 0.0024
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0574 0.1888 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0083 0.0267
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.004 0.0093 0.2676
Onchocerca volvulus 0.0044 0.0107 0.0623
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0743
Schistosoma mansoni acetyl-CoA synthetase 0.0044 0.0107 0.0107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0107 0.0317 0.163
Echinococcus multilocularis 0.004 0.0093 0.0089
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0065 0.0494
Entamoeba histolytica acyl-coA synthetase, putative 0.0151 0.0466 1
Brugia malayi CHD4 protein 0.0017 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0079
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.1054 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0083 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0137 0.0419 0.0419
Echinococcus multilocularis chromobox protein 1 0.0075 0.021 0.0206
Echinococcus multilocularis geminin 0.0519 0.1706 0.1702
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0083 0.0267
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0107 0.0103
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0031 0.0027
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0031 0.0027
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0044 0.0107 0.0103
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0044 0.0107 0.0405
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0242 0.0242
Schistosoma mansoni BC026374 protein (S09 family) 0.0504 0.1654 0.1654
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0037 0.0644
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0024 0.002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.0429 0.0425
Plasmodium vivax acyl-CoA synthetase, putative 0.0113 0.0338 1
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0107 0.0103
Onchocerca volvulus 0.004 0.0093 0.0541
Brugia malayi Heterochromatin protein 1 0.0075 0.021 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0743
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0015
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0091 0.0091
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0044 0.0107 0.1988
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0429 0.0429
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0107 0.0405
Echinococcus multilocularis carboxylesterase 5A 0.2984 1 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0044 0.0107 0.0375
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.002
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.004 0.0093 0.2676
Onchocerca volvulus 0.0037 0.0083 0.048
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0089
Loa Loa (eye worm) hypothetical protein 0.0151 0.0466 0.0463
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0429 0.0425
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0066 0.0321
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0037 0.0229
Schistosoma mansoni gliotactin 0.0504 0.1654 0.1654
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0091 0.0087
Mycobacterium ulcerans acetyl-CoA synthetase 0.0044 0.0107 0.0375
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0066 0.0321
Loa Loa (eye worm) hypothetical protein 0.0151 0.0466 0.0463
Echinococcus multilocularis cpg binding protein 0.0093 0.0272 0.0268
Brugia malayi hypothetical protein 0.0027 0.0049 0.0045
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.1054 1
Schistosoma mansoni cpg binding protein 0.0093 0.0272 0.0272
Brugia malayi Carboxylesterase family protein 0.2984 1 1
Leishmania major hypothetical protein, conserved 0.0027 0.0049 0.0427
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0098 0.0287 0.0283
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0574 0.1888 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0024 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.003 0.01
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0112 0.0942
Loa Loa (eye worm) hypothetical protein 0.2984 1 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0326 0.1054 1
Loa Loa (eye worm) hypothetical protein 0.0504 0.1654 0.1651
Echinococcus multilocularis dnaJ subfamily B 0.1259 0.4196 0.4193
Schistosoma mansoni hypothetical protein 0.0074 0.0207 0.0207
Schistosoma mansoni regulator of G protein signaling 0.002 0.0024 0.0024
Echinococcus multilocularis chromobox protein 1 0.0075 0.021 0.0206
Loa Loa (eye worm) hypothetical protein 0.004 0.0091 0.0087
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0083 0.0267
Onchocerca volvulus 0.0088 0.0255 0.152
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0022 0.0031 0.0814
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0022 0.0031 0.0814
Echinococcus multilocularis acetylcholinesterase 0.2984 1 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0242 0.0238
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0031 0.0027
Leishmania major DNA polymerase eta, putative 0.004 0.0091 0.0827
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0083 0.0079
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0151 0.0466 0.2502
Schistosoma mansoni regulator of G protein signaling 0.002 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0073
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0044 0.0107 0.0405
Schistosoma mansoni tar DNA-binding protein 0.0137 0.0419 0.0419
Mycobacterium ulcerans hypothetical protein 0.0172 0.0535 0.2688
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0504 0.1654 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0188 0.0589 0.0589
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0099 0.0576
Echinococcus granulosus GPCR family 2 0.0034 0.0073 0.0069
Trypanosoma cruzi UDP-galactopyranose mutase 0.004 0.0093 0.0767
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0083 0.1068
Echinococcus granulosus dna polymerase eta 0.004 0.0091 0.0087
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.0419 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0066
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0016 0.0012
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0044 0.0107 0.0375
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0065 0.0494
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0044 0.0107 0.0103
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0151 0.0466 0.2318
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0504 0.1654 0.9427
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0504 0.1654 0.1654
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0083 0.0248
Toxoplasma gondii histone lysine methyltransferase SET1 0.0168 0.0521 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0107 0.0897
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0107 0.0897
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0743
Mycobacterium ulcerans acyl-CoA synthetase 0.0151 0.0466 0.2318
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0044 0.0107 0.1619
Onchocerca volvulus 0.0033 0.0068 0.0391
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0073
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0151 0.0466 0.2502
Chlamydia trachomatis protoporphyrinogen oxidase 0.004 0.0093 0.1864
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0024 0.002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0073 0.0069
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0107 0.0569
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0024 0.002
Trichomonas vaginalis chromobox protein, putative 0.0045 0.011 0.0587
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0323 0.0319
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.0476 0.4498
Mycobacterium ulcerans beta-lactamase 0.0037 0.0083 0.0248
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0024 0.002
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0244 0.0779 0.0779
Mycobacterium tuberculosis Carboxylesterase LipT 0.0504 0.1654 0.9427
Echinococcus granulosus dna polymerase kappa 0.004 0.0091 0.0087
Schistosoma mansoni regulator of G protein signaling 0.002 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0089
Echinococcus granulosus dnaJ subfamily B 0.1259 0.4196 0.4193
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0049 0.0344
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0151 0.0466 1
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.04 0.0396
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0083 0.0083
Toxoplasma gondii proteasome regulatory subunit 0.0022 0.0031 0.0525
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0093 0.0326
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0066 0.0321
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0073 0.0069
Mycobacterium ulcerans hypothetical protein 0.0151 0.0466 0.2318
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0107 0.0405
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0065 0.1179
Echinococcus granulosus acetylcholinesterase 0.2984 1 1
Brugia malayi chromobox protein homolog 3 0.0042 0.0099 0.0095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0323 0.0319
Brugia malayi Carboxylesterase family protein 0.0504 0.1654 0.1651
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0091 0.0312
Schistosoma mansoni cpg binding protein 0.0093 0.0272 0.0272
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0044 0.0107 0.1866
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0107 0.0317 0.163
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.0535 0.2901
Mycobacterium tuberculosis Possible oxidoreductase 0.004 0.0093 0.0326
Brugia malayi PXA domain containing protein 0.002 0.0024 0.002
Trichomonas vaginalis chromobox protein, putative 0.0075 0.021 0.1199
Leishmania major mitochondrial DNA polymerase beta 0.0326 0.1054 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0024 0.0024
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0083 0.0424
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0044 0.0107 0.0897
Schistosoma mansoni hypothetical protein 0.0519 0.1706 0.1706
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0743
Schistosoma mansoni neuroligin 3 (S09 family) 0.0504 0.1654 0.1654
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0429 0.0429
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0107 0.0375
Loa Loa (eye worm) hypothetical protein 0.0027 0.0049 0.0045
Onchocerca volvulus 0.0044 0.0107 0.0623
Loa Loa (eye worm) oxidoreductase 0.0044 0.0107 0.0103
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0019 0.0015
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0046 0.0111 0.2078
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0113 0.0338 0.1752
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0429 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0068
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0019 0.0015
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0044 0.0107 0.0405
Onchocerca volvulus 0.0504 0.1654 1
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0024 0.002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0083 0.0079
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0107 0.1988
Trypanosoma brucei unspecified product 0.0027 0.0049 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0068
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0091 0.0087
Onchocerca volvulus 0.0151 0.0466 0.2802
Echinococcus multilocularis expressed protein 0.0388 0.1262 0.1258
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0068
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0091 0.0743
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.004 0.0093 0.2676
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0037 0.0998
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0743
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0083 0.0424
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0024 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0429 0.0425
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0024 0.002
Plasmodium falciparum protoporphyrinogen oxidase 0.004 0.0093 0.2676
Brugia malayi beta-lactamase 0.0037 0.0083 0.0079
Mycobacterium ulcerans carboxylesterase, LipT 0.0504 0.1654 0.8735
Schistosoma mansoni Lysine-specific histone demethylase 1 0.004 0.0093 0.0093
Loa Loa (eye worm) proteasome 26S subunit 0.0017 0.0014 0.001
Toxoplasma gondii propionate-CoA ligase 0.0044 0.0107 0.1988
Echinococcus granulosus chromobox protein 1 0.0075 0.021 0.0206
Loa Loa (eye worm) hypothetical protein 0.0504 0.1654 0.1651
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0035 0.013
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0024 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0091 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.002
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0044 0.0107 0.0375
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0107 0.0375
Mycobacterium leprae Probable lipase LipE 0.0037 0.0083 0.1068
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0024 0.002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0068
Trypanosoma cruzi UDP-galactopyranose mutase 0.004 0.0093 0.0767
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0107 0.0375
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.0476 0.4448
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0083 0.0267
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0107 0.0897
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0091 0.1504
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0091 0.0743
Schistosoma mansoni cpg binding protein 0.0088 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.1096 0.3648 0.3645
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0083 0.0424
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0019 0.0446
Brugia malayi Carboxylesterase family protein 0.0504 0.1654 0.1651
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0107 0.0375
Loa Loa (eye worm) hypothetical protein 0.0098 0.0287 0.0283
Loa Loa (eye worm) hypothetical protein 0.0504 0.1654 0.1651
Echinococcus granulosus axis inhibition protein axin 0.002 0.0024 0.002
Trichomonas vaginalis rotamase, putative 0.0033 0.0068 0.0329
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0151 0.0466 0.2318
Plasmodium vivax protoporphyrinogen oxidase, putative 0.004 0.0093 0.2676
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0066 0.0321
Loa Loa (eye worm) carboxylesterase 0.2984 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.002
Echinococcus multilocularis muscleblind protein 0.1096 0.3648 0.3645
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0044 0.0107 0.308
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0058 0.0269
Plasmodium falciparum acyl-CoA synthetase 0.0113 0.0338 1
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0107 0.0979
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0049 0.0045
Echinococcus multilocularis protoporphyrinogen oxidase 0.004 0.0093 0.0089
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0145 0.1266
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0066 0.0321
Mycobacterium ulcerans oxidoreductase 0.004 0.0093 0.0302
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0083 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0083 0.0083
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0504 0.1654 0.9427
Loa Loa (eye worm) hypothetical protein 0.2984 1 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0024 0.002
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0073
Brugia malayi RNA binding protein 0.0137 0.0419 0.0415
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0024 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0066 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0068
Mycobacterium ulcerans protoporphyrinogen oxidase 0.004 0.0093 0.0302
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.0761 0.4221
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0504 0.1654 0.1651
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0242 0.0238
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0017 0.0014 0.001
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0044 0.0107 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0137 0.0419 0.0419
Brugia malayi AMP-binding enzyme family protein 0.0151 0.0466 0.0463
Leishmania major hypothetical protein, conserved 0.0018 0.0019 0.0142
Loa Loa (eye worm) hypothetical protein 0.0044 0.0107 0.0103
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0068 0.0064
Echinococcus multilocularis lysine specific histone demethylase 1A 0.004 0.0093 0.0089
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.0476 0.4448
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.0429 0.0425
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0019 0.0052
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0079
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0504 0.1654 0.1654
Loa Loa (eye worm) carboxylesterase 0.0504 0.1654 0.1651
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.023 0.0732 0.0728
Echinococcus granulosus lysine specific histone demethylase 1A 0.004 0.0093 0.0089
Brugia malayi beta-lactamase family protein 0.0037 0.0083 0.0079
Echinococcus granulosus muscleblind protein 0.1096 0.3648 0.3645
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0066 0.0321
Echinococcus multilocularis expressed protein 0.0033 0.0068 0.0064
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0024 0.0024
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0083 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0049 0.0344
Loa Loa (eye worm) RGS-3 protein 0.002 0.0024 0.002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0083 0.0267
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0031 0.0027
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0151 0.0466 0.2318
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0107 0.0979
Echinococcus granulosus carboxylesterase 5A 0.2984 1 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0107 0.0979
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0429 0.0425
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0905 0.3005 0.3002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0066
Loa Loa (eye worm) hypothetical protein 0.0034 0.0073 0.0069
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0091 0.0471
Echinococcus granulosus expressed protein 0.0388 0.1262 0.1258
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.004 0.0093 0.1305
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0024 0.002
Onchocerca volvulus 0.0037 0.0083 0.048
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0024 0.002
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0024 0.002
Brugia malayi SET domain containing protein 0.0014 0.0005 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0743
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0044 0.0107 0.0375
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0073
Mycobacterium tuberculosis Conserved protein 0.0037 0.0083 0.0267
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0024 0.002

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.