Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0239 | 0.6521 | 0.6521 |
Onchocerca volvulus | 0.005 | 0.0768 | 0.0647 | |
Trichomonas vaginalis | importin beta-1, putative | 0.0027 | 0.0075 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0301 | 0.0301 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0768 | 0.0938 |
Echinococcus multilocularis | acetylcholinesterase | 0.0294 | 0.8188 | 0.8188 |
Brugia malayi | Carboxylesterase family protein | 0.0294 | 0.8188 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0294 | 0.8188 | 0.8188 |
Brugia malayi | Carboxylesterase family protein | 0.0294 | 0.8188 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0294 | 0.8188 | 0.8188 |
Echinococcus granulosus | importin subunit beta 1 | 0.0033 | 0.0266 | 0.0266 |
Plasmodium vivax | importin-beta 2, putative | 0.0033 | 0.0266 | 0.8822 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.005 | 0.0768 | 0.1021 |
Leishmania major | importin beta-1 subunit, putative | 0.0027 | 0.0075 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0294 | 0.8188 | 0.8188 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.005 | 0.0768 | 0.0768 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0768 | 0.0938 |
Schistosoma mansoni | acetylcholinesterase | 0.005 | 0.0768 | 0.0768 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0301 | 0.0368 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0301 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0266 | 0.0266 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0301 | 0.0301 |
Onchocerca volvulus | 0.0272 | 0.7525 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.005 | 0.0768 | 0.0768 |
Echinococcus granulosus | neuroligin | 0.005 | 0.0768 | 0.0768 |
Trichomonas vaginalis | set domain proteins, putative | 0.0272 | 0.7525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.109 | 0.109 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.005 | 0.0768 | 0.5 |
Brugia malayi | RNA, U transporter 1 | 0.0094 | 0.2121 | 0.259 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.005 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0768 | 0.0768 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0301 | 0.0301 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0266 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0353 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0768 | 0.0768 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.109 | 0.1332 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0511 | 0.0511 |
Plasmodium falciparum | importin beta, putative | 0.0033 | 0.0266 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0075 | 0.01 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0075 | 0.01 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0266 | 1 |
Brugia malayi | hypothetical protein | 0.005 | 0.0768 | 0.0938 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0768 | 0.0768 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.0263 | 0.0263 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0294 | 0.8188 | 0.8188 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0511 | 0.0624 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 1 | 1 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0768 | 0.0768 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0768 | 0.0938 |
Echinococcus multilocularis | neuroligin | 0.005 | 0.0768 | 0.0768 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.005 | 0.0768 | 0.0768 |
Echinococcus granulosus | acetylcholinesterase | 0.0294 | 0.8188 | 0.8188 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0301 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.8188 | 0.8188 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0511 | 0.0511 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0301 | 0.0301 |
Echinococcus granulosus | carboxylesterase 5A | 0.0294 | 0.8188 | 0.8188 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0033 | 0.0266 | 0.0266 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.005 | 0.0768 | 0.0768 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0768 | 0.0938 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.005 | 0.0768 | 0.5 |
Onchocerca volvulus | 0.005 | 0.0768 | 0.0647 | |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.8188 | 0.8188 |
Schistosoma mansoni | importin beta-1 | 0.0033 | 0.0266 | 0.0266 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0353 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0768 | 0.0768 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0301 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0075 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.109 | 0.1332 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0301 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0033 | 0.0266 | 0.0324 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.005 | 0.0768 | 0.0768 |
Onchocerca volvulus | 0.005 | 0.0768 | 0.0647 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.005 | 0.0768 | 0.0768 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0301 | 0.0301 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.005 | 0.0768 | 0.1021 |
Brugia malayi | Pre-SET motif family protein | 0.0239 | 0.6521 | 0.7965 |
Schistosoma mansoni | gliotactin | 0.005 | 0.0768 | 0.0768 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0033 | 0.0266 | 0.8822 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0768 | 0.0768 |
Onchocerca volvulus | 0.005 | 0.0768 | 0.0647 | |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0768 | 0.0768 |
Echinococcus granulosus | acetylcholinesterase | 0.0294 | 0.8188 | 0.8188 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.005 | 0.0768 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.005 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | carboxylesterase | 0.0294 | 0.8188 | 0.8188 |
Onchocerca volvulus | 0.005 | 0.0768 | 0.0647 | |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0301 | 0.0301 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.005 | 0.0768 | 0.5 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0027 | 0.0075 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.005 | 0.0768 | 0.0768 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.005 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.109 | 0.109 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.