Detailed information for compound 1704420

Basic information

Technical information
  • TDR Targets ID: 1704420
  • Name: N-cyclopropyl-2,3-di(thiophen-2-yl)quinoxalin e-6-carboxamide
  • MW: 377.483 | Formula: C20H15N3OS2
  • H donors: 1 H acceptors: 3 LogP: 3.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)nc(c(n2)c1cccs1)c1cccs1)NC1CC1
  • InChi: 1S/C20H15N3OS2/c24-20(21-13-6-7-13)12-5-8-14-15(11-12)23-19(17-4-2-10-26-17)18(22-14)16-3-1-9-25-16/h1-5,8-11,13H,6-7H2,(H,21,24)
  • InChiKey: FCVPTSOUJSWVEW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclopropyl-2,3-bis(2-thienyl)quinoxaline-6-carboxamide
  • N-cyclopropyl-2,3-bis(2-thienyl)-6-quinoxalinecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0016 0.0166 0.001
Onchocerca volvulus 0.0016 0.0166 0.6147
Loa Loa (eye worm) hypothetical protein 0.002 0.0261 0.0261
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0261 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0261 0.0261
Onchocerca volvulus 0.0016 0.0166 0.6147
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.3155 0.8507
Brugia malayi nuclear receptor NHR-88 0.002 0.0261 0.0261
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0166 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0261 0.0261
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.137 0.4283
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0238 0.0238
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.137 0.4343
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0241 0.6529 0.6529
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.2976 0.2976
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.1278 0.9244
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0166 0.001
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.024 0.6497 0.6497
Toxoplasma gondii thioredoxin reductase 0.0046 0.1002 0.697
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1002 0.1002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0238 0.0238
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.137 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0166 0.0116
Loa Loa (eye worm) hypothetical protein 0.002 0.0261 0.0261
Leishmania major cathepsin L-like protease 0.0062 0.1454 0.1319
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0015 0.0015
Leishmania major cathepsin L-like protease 0.0016 0.0166 0.001
Onchocerca volvulus 0.0016 0.0166 0.6147
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.2661 0.8837
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1454 0.1319
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0261 0.0704
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.137 0.3571
Loa Loa (eye worm) hypothetical protein 0.0363 1 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.002 0.0261 0.0261
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0156 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0521 0.0521
Brugia malayi Cathepsin L-like precursor 0.0011 0.0015 0.0015
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0261 0.068
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.1278 0.9244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1454 0.1319
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0261 0.0261
Brugia malayi Cytochrome P450 family protein 0.0029 0.0521 0.0521
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0261 0.0828
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0015
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0166 0.0526
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0261 0.068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1454 0.1319
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0156 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0261 0.0704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1454 0.1319
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0166 0.6147
Brugia malayi Cathepsin L-like precursor 0.0011 0.0015 0.0015
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.1278 0.1278
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0166 0.0166
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0166 0.0448
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0261 0.068
Trypanosoma brucei trypanothione reductase 0.0046 0.1002 0.0859
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0238 0.0675
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0261 0.0261
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0261 0.068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0261 0.0828
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0261 0.0828
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.3155 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0166 0.0166
Schistosoma mansoni nuclear hormone receptor 0.002 0.0261 0.068
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0166 0.0433
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0166 1
Plasmodium falciparum glutathione reductase 0.0046 0.1002 1
Brugia malayi Nuclear hormone receptor-like 1 0.0241 0.6529 0.6529
Treponema pallidum NADH oxidase 0.0016 0.0156 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.137 0.3571
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0238 0.0083
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.2976 0.2976
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0166 1
Brugia malayi glutathione reductase 0.0046 0.1002 0.1002
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0166 0.0433
Brugia malayi Cytochrome P450 family protein 0.0019 0.0238 0.0238
Schistosoma mansoni thyroid hormone receptor 0.0141 0.3708 0.9665
Mycobacterium tuberculosis Probable reductase 0.0104 0.2661 0.8837
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0261 0.068
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0166 0.6147
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0166 0.0448
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.1081 0.0939
Loa Loa (eye worm) cysteine protease 0.0016 0.0166 0.0166
Onchocerca volvulus 0.002 0.0261 1
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0363 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0166 0.0166
Onchocerca volvulus 0.0016 0.0166 0.6147
Loa Loa (eye worm) ctsf protein 0.0016 0.0166 0.0166
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0156 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0261 0.0261
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1002 0.0859
Loa Loa (eye worm) glutathione reductase 0.0046 0.1002 0.1002
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.1278 0.3448
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.2661 0.8837
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0261 0.0261
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0261 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1454 0.1319
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0261 0.0704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1454 0.1319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0261 0.0828
Entamoeba histolytica cysteine protease, putative 0.0016 0.0166 1
Leishmania major trypanothione reductase 0.0046 0.1002 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0261 0.0261
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.1278 0.114
Plasmodium falciparum thioredoxin reductase 0.0046 0.1002 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0261 0.0261
Echinococcus granulosus cathepsin l1 0.0011 0.0015 0.0046
Onchocerca volvulus 0.0016 0.0166 0.6147
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0261 0.0828
Echinococcus multilocularis cysteine protease 0.0016 0.0166 0.0448
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1454 0.1319
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0156 0.9353
Loa Loa (eye worm) fibroinase 0.0016 0.0166 0.0166
Onchocerca volvulus 0.0016 0.0166 0.6147
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.2661 0.8837
Trypanosoma brucei C-8 sterol isomerase, putative 0.0363 1 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0261 0.0261
Brugia malayi Cathepsin L-like precursor 0.0016 0.0166 0.0166
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2991 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0166 1
Echinococcus multilocularis cysteine protease 0.0016 0.0166 0.0448
Loa Loa (eye worm) hypothetical protein 0.002 0.0261 0.0261
Brugia malayi ecdysteroid receptor 0.002 0.0261 0.0261
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0261 0.0704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0166 0.0166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0166 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0261 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0261 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1454 0.1319
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0261 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2991 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0156 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2991 1
Brugia malayi Thioredoxin reductase 0.0046 0.1002 0.1002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.1278 0.3959
Leishmania major cathepsin L-like protease 0.0062 0.1454 0.1319
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0261 0.0704
Brugia malayi Cathepsin L-like precursor 0.0016 0.0166 0.0166
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0166 0.0116
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.1303 0.1165
Leishmania major C-8 sterol isomerase-like protein 0.0363 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0166 1
Leishmania major cathepsin L-like protease 0.0016 0.0166 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0261 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1454 0.1319
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1002 0.2985
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0261 0.0261
Brugia malayi MH2 domain containing protein 0.0115 0.2976 0.2976
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0261 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0261 0.0261
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0156 0.0495
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.3708 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0166 1
Brugia malayi cathepsin L-like precursor 0.0011 0.0015 0.0015
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0238 0.0238
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0156 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.2661 0.8837
Loa Loa (eye worm) hypothetical protein 0.0016 0.0166 0.0166
Toxoplasma gondii cathepsin CPL 0.0016 0.0166 0.0081
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0261 0.068
Brugia malayi Nuclear hormone receptor-like 1 0.0241 0.6529 0.6529
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0261 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0261 0.0261
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0238 0.0083
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0156 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1454 0.1319
Loa Loa (eye worm) hypothetical protein 0.0186 0.4968 0.4968
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1002 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0261 0.0828
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.1173 0.1173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1454 0.1319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0166 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.137 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0166 0.0448
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.137 0.3695
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0261 0.0261
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1002 0.2703
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0261 0.0828
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0037 0.0037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0261 0.068
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0261 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0261 0.0261
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0156 0.5
Brugia malayi steroid hormone receptor 0.002 0.0261 0.0261
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0166 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0261 0.0261
Plasmodium vivax vivapain-2 0.0016 0.0166 0.0116
Plasmodium vivax vivapain-2 0.0016 0.0166 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1454 0.1319
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0015 0.0038
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0166 0.0448
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0261 0.0261
Schistosoma mansoni coup transcription factor 0.002 0.0261 0.068
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0156 0.9353
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.137 0.1233
Brugia malayi Cathepsin L-like precursor 0.0016 0.0166 0.0166
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.2661 0.8837
Echinococcus granulosus cathepsin l1 0.0016 0.0166 0.0526
Loa Loa (eye worm) hypothetical protein 0.002 0.0261 0.0261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0166 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.137 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0261 0.0261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0166 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0238 0.0238
Plasmodium vivax glutathione reductase, putative 0.0046 0.1002 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1454 0.1319
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0166 0.6147
Schistosoma mansoni hypothetical protein 0.0122 0.3155 0.8223
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.1278 0.4052
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0261 0.068
Brugia malayi nuclear hormone receptor 0.002 0.0261 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1454 0.1319
Schistosoma mansoni thyroid hormone receptor 0.0141 0.3708 0.9665
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0166 0.0526
Leishmania major cytochrome p450-like protein 0.0019 0.0238 0.0083
Brugia malayi Nuclear hormone receptor-like 1 0.025 0.679 0.679
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2991 1
Leishmania major cathepsin L-like protease 0.0016 0.0166 0.001
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0166 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0261 0.0261
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0261 0.0261
Leishmania major cathepsin L-like protease 0.0016 0.0166 0.001
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.1278 0.3332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0166 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0261 0.0828
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0261 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0261 0.0261
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1002 0.3177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0261 0.0704
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0261 0.0704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0166 1
Leishmania major cathepsin L-like protease 0.0062 0.1454 0.1319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0166 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.137 1
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0261 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0261 0.0828
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0166 1
Onchocerca volvulus 0.0016 0.0166 0.6147
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1454 0.1319
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0238 0.0083

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 20 uM PubChem BioAssay. High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, compounds from Powder Set 01. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) 20 uM PubChem BioAssay. High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, compounds from Powder Set 01. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) 20 uM PubChem BioAssay. High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Lethal Factor protease, compounds from Powder Set 01. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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