Detailed information for compound 1704513

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 551.656 | Formula: C25H37N5O7S
  • H donors: 1 H acceptors: 6 LogP: 0.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H](N1C[C@H](C)[C@@H](OCc2n(CCCC1=O)nnc2)CN(S(=O)(=O)c1ccc2c(c1)OCCCO2)C)C
  • InChi: 1S/C25H37N5O7S/c1-18-14-29(19(2)16-31)25(32)6-4-9-30-20(13-26-27-30)17-37-24(18)15-28(3)38(33,34)21-7-8-22-23(12-21)36-11-5-10-35-22/h7-8,12-13,18-19,24,31H,4-6,9-11,14-17H2,1-3H3/t18-,19+,24-/m0/s1
  • InChiKey: OJWZSZMXEDUVHM-GLDPYIMESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0072 0.1071 0.1956
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0085 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1067 0.1922
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0496
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.2381 0.457
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0368 0.0667
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0401 0.0695
Entamoeba histolytica hypothetical protein 0.0041 0.0489 1
Toxoplasma gondii methionine aminopeptidase 0.0279 0.5085 0.9328
Schistosoma mansoni ap endonuclease 0.0022 0.0106 0.0169
Leishmania major transcription factor-like protein 0.0035 0.0368 0.0634
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0063 0.01
Toxoplasma gondii hypothetical protein 0.0019 0.0052 0.0096
Brugia malayi Carboxylesterase family protein 0.0072 0.1071 0.1956
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0489 0.0456
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.027 0.4917 0.9645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0085 0.0147
Schistosoma mansoni hypothetical protein 0.0039 0.0439 0.07
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0035 0.0368 0.0527
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.1067 0.1922
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0035 0.0368 0.0634
Brugia malayi metallopeptidase family M24 containing protein 0.0035 0.0368 0.0667
Echinococcus granulosus neuropeptide receptor A26 0.0533 1 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0401 0.0695
Echinococcus granulosus acetylcholinesterase 0.0072 0.1071 0.104
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0035 0.0368 0.0335
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0035 0.0368 0.0592
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0085 0.0075
Echinococcus multilocularis xaa Pro dipeptidase 0.0035 0.0368 0.0335
Giardia lamblia Methionine aminopeptidase 0.0035 0.0368 0.8884
Loa Loa (eye worm) hypothetical protein 0.0076 0.1164 0.2129
Loa Loa (eye worm) carboxylesterase 0.0072 0.1071 0.1956
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0049 0.0014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0085 0.0147
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0279 0.5085 0.9322
Plasmodium vivax FACT complex subunit SPT16, putative 0.0035 0.0368 0.0592
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0345 0.0551
Plasmodium falciparum thioredoxin reductase 0.0107 0.1749 0.3148
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0085 0.0051
Schistosoma mansoni survival motor neuron protein 0.0054 0.0726 0.1158
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0085 0.0147
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0279 0.5085 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0756 0.0724
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0045
Plasmodium falciparum HP12 protein homolog, putative 0.0019 0.0052 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.2259 0.4139
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0726 0.1323
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0298 0.5451 0.5435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0085 0.0147
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0298 0.5451 0.5435
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0401 0.0695
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0401 0.0695
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.2381 0.457
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0298 0.5451 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0243 0.4392 0.8609
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Entamoeba histolytica hypothetical protein 0.0041 0.0489 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0106 0.0117
Echinococcus multilocularis zinc finger protein 0.0022 0.0118 0.0084
Brugia malayi glutathione reductase 0.0107 0.1749 0.3203
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0049 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0586 0.1066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.008
Echinococcus multilocularis neuropeptide receptor A26 0.0533 1 1
Brugia malayi hypothetical protein 0.0041 0.0489 0.0888
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0035 0.0368 0.0675
Loa Loa (eye worm) ctsf protein 0.0019 0.0049 0.008
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0085 0.0051
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0401 0.0653
Leishmania major cathepsin L-like protease 0.0071 0.1067 0.1922
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0115 0.1903 0.1875
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.1903 0.3037
Schistosoma mansoni thyroid hormone receptor 0.0149 0.257 0.4102
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0035 0.0368 0.0527
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0276 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1067 0.1922
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0085 0.0051
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0035 0.0368 0.0588
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0035 0.0368 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0085 0.0147
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.1903 0.3037
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0035 0.0368 0.0667
Plasmodium vivax glutathione reductase, putative 0.0107 0.1749 0.3148
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0139 0.2381 0.457
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.4783 0.4765
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0211 0.0379
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0085 0.0136
Onchocerca volvulus 0.0021 0.0085 0.0075
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0401 0.0695
Echinococcus multilocularis methionine aminopeptidase, type I 0.0035 0.0368 0.0335
Echinococcus granulosus thioredoxin glutathione reductase 0.0107 0.1749 0.1721
Echinococcus multilocularis xaa pro aminopeptidase 0.0035 0.0368 0.0335
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0107 0.1749 0.3301
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0035 0.0368 0.0335
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0045
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0037 0.0401 0.007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0085 0.0051
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0049 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0756 0.1206
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.1903 0.3037
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0401 0.0593
Schistosoma mansoni hypothetical protein 0.0024 0.0142 0.0226
Schistosoma mansoni hypothetical protein 0.0128 0.2171 0.3466
Plasmodium falciparum aminopeptidase P 0.0035 0.0368 0.0592
Schistosoma mansoni thyroid hormone receptor 0.0149 0.257 0.4102
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0045
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0063 0.01
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0276 0.0463
Trypanosoma cruzi trypanothione reductase, putative 0.0107 0.1749 0.3179
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0298 0.5451 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0085 0.0147
Leishmania major cathepsin L-like protease 0.0071 0.1067 0.1922
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0401 0.0736
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0085 0.0136
Entamoeba histolytica methionine aminopeptidase, putative 0.0035 0.0368 0.7262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0085 0.0147
Loa Loa (eye worm) thioredoxin reductase 0.0107 0.1749 0.3203
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0298 0.5451 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0085 0.0136
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0401 0.0593
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0787 0.1435
Mycobacterium tuberculosis Probable dehydrogenase 0.0243 0.4392 0.8609
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Schistosoma mansoni hypothetical protein 0.0054 0.0726 0.1158
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.1903 0.3037
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0035 0.0368 0.0634
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0756 0.1206
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0106 0.0185
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0401 0.0695
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0439 0.0796
Brugia malayi MH2 domain containing protein 0.0133 0.2259 0.4139
Brugia malayi Pre-SET motif family protein 0.0034 0.0345 0.0625
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0279 0.5085 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0401 0.0695
Brugia malayi Nuclear hormone receptor-like 1 0.0254 0.4604 0.8445
Brugia malayi Carboxylesterase family protein 0.0072 0.1071 0.1956
Leishmania major hypothetical protein, conserved 0.0035 0.0368 0.0634
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0085 0.0147
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0401 0.0695
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.008
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0401 0.0724
Loa Loa (eye worm) hypothetical protein 0.0057 0.0787 0.1435
Loa Loa (eye worm) acetylcholinesterase 1 0.0072 0.1071 0.1956
Echinococcus granulosus xaa Pro dipeptidase 0.0035 0.0368 0.0335
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0184 0.0294
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0147
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0401 0.0695
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.257 0.2545
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0345 0.0634
Trypanosoma brucei trypanothione reductase 0.0107 0.1749 0.3179
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.2381 0.457
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0055
Echinococcus multilocularis cysteine protease 0.0019 0.0049 0.0014
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0085 0.0147
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0282 0.0508
Echinococcus multilocularis acetylcholinesterase 0.0072 0.1071 0.104
Echinococcus multilocularis Proliferation associated protein 2G4 0.0035 0.0368 0.0335
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0106 0.0185
Schistosoma mansoni peptidase 0.0035 0.0368 0.0588
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0282 0.0508
Loa Loa (eye worm) cysteine protease 0.0019 0.0049 0.008
Schistosoma mansoni lamin 0.0031 0.0282 0.045
Onchocerca volvulus 0.027 0.4916 1
Echinococcus granulosus xaa pro aminopeptidase 0.0035 0.0368 0.0335
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.048 0.0447
Brugia malayi Nuclear hormone receptor-like 1 0.0264 0.4792 0.879
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0035 0.0368 0.0588
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0049 0.008
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.008
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0035 0.0368 0.0634
Leishmania major methionine aminopeptidase 2, putative 0.0035 0.0368 0.0634
Echinococcus granulosus intermediate filament protein 0.0031 0.0282 0.0248
Schistosoma mansoni hypothetical protein 0.0017 0.0024 0.0038
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Echinococcus granulosus xaa Pro dipeptidase 0.0035 0.0368 0.0335
Onchocerca volvulus 0.0031 0.0282 0.0479
Plasmodium vivax peptidase, putative 0.0035 0.0368 0.0592
Loa Loa (eye worm) DNA-binding protein 0.0035 0.0368 0.0667
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0085 0.0075
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0115 0.1903 0.1875
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0085 0.0051
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.4783 0.4765
Loa Loa (eye worm) hypothetical protein 0.0049 0.0628 0.1143
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0298 0.5451 1
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0049 0.0045
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0085 0.0051
Loa Loa (eye worm) hypothetical protein 0.0081 0.1248 0.2282
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0756 0.1378
Schistosoma mansoni aldehyde dehydrogenase 0.0139 0.2381 0.38
Trypanosoma brucei methionine aminopeptidase, putative 0.0298 0.5451 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0279 0.5085 1
Treponema pallidum NADH oxidase 0.0037 0.0401 0.0593
Schistosoma mansoni intermediate filament proteins 0.0031 0.0282 0.045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0085 0.0147
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0085 0.0136
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0787 0.1435
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0401 0.0593
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0085 0.0147
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0085 0.0136
Mycobacterium ulcerans dipeptidase 0.0035 0.0368 0.0527
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0401 0.0368
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Loa Loa (eye worm) hypothetical protein 0.003 0.0271 0.0488
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0139 0.2381 0.4343
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0106 0.0071
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0085 0.0051
Toxoplasma gondii methionine aminopeptidase 0.0298 0.5451 1
Leishmania major cathepsin L-like protease 0.0071 0.1067 0.1922
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0035 0.0054
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0085 0.0136
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.2171 0.2144
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0049 0.0014
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0243 0.4392 0.8532
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.048 0.0447
Echinococcus granulosus acetylcholinesterase 0.0072 0.1071 0.104
Brugia malayi Bromodomain containing protein 0.0086 0.1342 0.2455
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0401 0.0593
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0401 0.0593
Echinococcus multilocularis acetylcholinesterase 0.0072 0.1071 0.104
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0085 0.0147
Treponema pallidum aminopeptidase P 0.0035 0.0368 0.0527
Toxoplasma gondii melibiase subfamily protein 0.0115 0.1903 0.3491
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0211 0.0379
Schistosoma mansoni aldehyde dehydrogenase 0.0139 0.2381 0.38
Loa Loa (eye worm) hypothetical protein 0.0253 0.4581 0.8403
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0279 0.5085 0.9322
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0276 0.042
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.2171 0.2144
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0282 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0085 0.0147
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0276 0.0463
Toxoplasma gondii exonuclease III APE 0.0022 0.0106 0.0194
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0085 0.0051
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0085 0.0051
Echinococcus multilocularis neuropeptide s receptor 0.0533 1 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0107 0.1749 0.1721
Plasmodium falciparum thioredoxin reductase 0.0037 0.0401 0.0653
Echinococcus granulosus carboxylesterase 5A 0.0072 0.1071 0.104
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0279 0.5085 0.9328
Schistosoma mansoni zinc finger protein 0.0017 0.0024 0.0038
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0401 0.0695
Toxoplasma gondii aldehyde dehydrogenase 0.0139 0.2381 0.4368
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0035 0.0368 0.0657
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0085 0.0147
Brugia malayi intermediate filament protein 0.0031 0.0282 0.0508
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0055
Schistosoma mansoni zinc finger protein 0.0022 0.0118 0.0189
Trypanosoma cruzi aminopeptidase P1, putative 0.0035 0.0368 0.0634
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0085 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0147
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0035 0.0368 0.0667
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Brugia malayi ecdysteroid receptor 0.0021 0.0085 0.0147
Brugia malayi nuclear hormone receptor 0.0021 0.0085 0.0147
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0035 0.0368 0.0634
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0055
Loa Loa (eye worm) hypothetical protein 0.0044 0.0533 0.097
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.008
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0139 0.2381 0.2355
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0035 0.0368 0.0588
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0035 0.0368 0.0588
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0049 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0085 0.0147
Loa Loa (eye worm) hypothetical protein 0.0039 0.0439 0.0796
Brugia malayi Melibiase family protein 0.0076 0.1164 0.2129
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1067 0.1922
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0045
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0085 0.0147
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0035 0.0368 0.0634
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0276 0.0463
Treponema pallidum methionine aminopeptidase (map) 0.0279 0.5085 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0063 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1067 0.1922
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0085 0.0136
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0106 0.0151
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0076 0.0131
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0147
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0401 0.0593
Mycobacterium ulcerans methionine aminopeptidase 0.0279 0.5085 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0401 0.0727
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Brugia malayi Thioredoxin reductase 0.0107 0.1749 0.3203
Echinococcus multilocularis carboxylesterase 5A 0.0072 0.1071 0.104
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0035 0.0368 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0085 0.0147
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0085 0.0136
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0771 0.1377
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0085 0.0051
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0401 0.0695
Schistosoma mansoni ap endonuclease 0.0022 0.0106 0.0169
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0401 0.0695
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0279 0.5085 1
Echinococcus multilocularis methionyl aminopeptidase 2 0.0035 0.0368 0.0335
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0035 0.0368 0.0588
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0106 0.0117
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1067 0.1922
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0401 0.0736
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0401 1
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0401 0.0724
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0722 0.069
Entamoeba histolytica hypothetical protein 0.0041 0.0489 1
Brugia malayi steroid hormone receptor 0.0021 0.0085 0.0147
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0085 0.0147
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0276 0.042
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0139 0.2381 0.2355
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0489 0.078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1067 0.1922
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.027 0.4917 0.9664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1067 0.1922
Trichomonas vaginalis set domain proteins, putative 0.027 0.4916 1
Echinococcus granulosus methionine aminopeptidase type I 0.0035 0.0368 0.0335
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.1164 0.1858
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0035 0.0368 0.0657
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0115 0.1903 0.1875
Onchocerca volvulus 0.0031 0.0282 0.0479
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0035 0.0368 0.7262
Entamoeba histolytica aminopeptidase, putative 0.0035 0.0368 0.7262
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0279 0.5085 1
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0035 0.0368 0.0588
Onchocerca volvulus 0.0034 0.0345 0.061
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0072 0.1071 0.1709
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1067 0.1922
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0279 0.5085 0.8115
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0106 0.1298
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Mycobacterium tuberculosis Probable reductase 0.0243 0.4392 0.8609
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0085 0.0147
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0055
Echinococcus multilocularis cysteine protease 0.0019 0.0049 0.0014
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0298 0.5451 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0184 0.015
Loa Loa (eye worm) hypothetical protein 0.0263 0.4783 0.8773
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1067 0.1922
Leishmania major hypothetical protein, conserved 0.003 0.0276 0.0463
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.027 0.4917 0.9664
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0085 0.0051
Echinococcus granulosus cathepsin l1 0.0019 0.0049 0.0014
Loa Loa (eye worm) glutathione reductase 0.0107 0.1749 0.3203
Onchocerca volvulus Dipeptidase C homolog 0.0035 0.0368 0.0657
Mycobacterium ulcerans aminopeptidase 0.0035 0.0368 0.0527
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0085 0.0136
Leishmania major hypothetical protein, conserved 0.0019 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0041 0.0489 0.078
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0947 0.1701
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0045
Echinococcus granulosus zinc finger protein 0.0022 0.0118 0.0084
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0049 0.008
Loa Loa (eye worm) hypothetical protein 0.0053 0.0722 0.1316
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0035 0.0368 0.0634
Brugia malayi Bromodomain containing protein 0.0044 0.0532 0.0967
Brugia malayi hypothetical protein 0.002 0.0067 0.0113
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0085 0.0147
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0787 0.1435
Brugia malayi PHD-finger family protein 0.0028 0.0236 0.0424
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0489 0.0456
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0722 0.1152
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0106 0.0071
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0052 0.0052
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0063 0.0028
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.4281 0.7852
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0049 0.0045
Toxoplasma gondii cathepsin CPL 0.0019 0.0049 0.0089
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0279 0.5085 0.5068
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0106 0.0151
Trypanosoma brucei Metallopeptidase family M24, putative 0.0035 0.0368 0.0634
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0035 0.0368 0.0634
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0106 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0195 0.3466 0.5531
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0085 0.0075
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0298 0.5451 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0722 0.069
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0282 0.0508
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0243 0.4392 0.8609
Echinococcus granulosus lamin dm0 0.0031 0.0282 0.0248
Plasmodium vivax SET domain protein, putative 0.0034 0.0345 0.0549
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0035 0.0368 0.0592
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0142 0.0251
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0035 0.0368 0.0634
Echinococcus multilocularis lamin dm0 0.0031 0.0282 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1067 0.1922
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0085 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1067 0.1922
Plasmodium vivax methionine aminopeptidase 2, putative 0.0035 0.0368 0.0592
Echinococcus granulosus FACT complex subunit SPT16 0.0035 0.0368 0.0335
Toxoplasma gondii thioredoxin reductase 0.0107 0.1749 0.3209
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Echinococcus multilocularis FACT complex subunit SPT16 0.0035 0.0368 0.0335
Mycobacterium ulcerans dipeptidase PepE 0.0035 0.0368 0.0527
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0243 0.4392 0.8609
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0085 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.1071 0.1956
Schistosoma mansoni bromodomain containing protein 0.0072 0.1083 0.1729
Echinococcus multilocularis xaa Pro dipeptidase 0.0035 0.0368 0.0335
Brugia malayi metallopeptidase family M24 containing protein 0.0035 0.0368 0.0667
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0756 0.1378
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0345 0.0551
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0085 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0722 0.1152
Trypanosoma cruzi aminopeptidase P, putative 0.0035 0.0368 0.0634
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0401 0.0695
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0401 0.0653
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0279 0.5085 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0085 0.0147
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0401 0.0695
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0279 0.5085 0.8115
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.1164 0.1858
Echinococcus multilocularis lamin 0.0031 0.0282 0.0248
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0756 0.0724
Echinococcus multilocularis musashi 0.0031 0.0282 0.0248
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0243 0.4392 0.8609
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0401 0.0368
Giardia lamblia Xaa-Pro dipeptidase 0.0035 0.0368 0.8884
Entamoeba histolytica hypothetical protein, conserved 0.0035 0.0368 0.7262
Brugia malayi Pre-SET motif family protein 0.0237 0.4281 0.7852
Schistosoma mansoni lamin 0.0031 0.0282 0.045
Plasmodium falciparum methionine aminopeptidase 2 0.0035 0.0368 0.0592
Onchocerca volvulus 0.0054 0.0726 0.1391
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0401 0.0695
Brugia malayi hypothetical protein 0.0263 0.4783 0.8773
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0298 0.5451 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.008
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0035 0.0368 0.0675
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0401 0.0653
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0106 0.0151
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0035 0.0368 0.0634
Schistosoma mansoni hypothetical protein 0.0195 0.3466 0.5531
Loa Loa (eye worm) fibroinase 0.0019 0.0049 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1067 0.1922
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0321 0.0288
Brugia malayi Methionine aminopeptidase protein type I 0.0298 0.5451 1
Plasmodium vivax thioredoxin reductase, putative 0.0107 0.1749 0.3148
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0035 0.0368 0.0592
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0756 0.0724
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0756 0.1206
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0049 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0147
Brugia malayi initiation factor 2-associated protein. 0.0035 0.0368 0.0667
Schistosoma mansoni coup transcription factor 0.0021 0.0085 0.0136
Mycobacterium tuberculosis Dipeptidase PepE 0.0035 0.0368 0.0527
Entamoeba histolytica hypothetical protein 0.0041 0.0489 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.1004 0.0973
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.2259 0.4139
Plasmodium falciparum glutathione reductase 0.0107 0.1749 0.3148
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0276 0.0505
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0401 0.0695
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0254 0.4604 0.8445
Toxoplasma gondii creatinase domain-containing protein 0.0035 0.0368 0.0675
Toxoplasma gondii transcriptional elongation factor FACT140 0.0035 0.0368 0.0675
Loa Loa (eye worm) hypothetical protein 0.0035 0.0368 0.0667
Entamoeba histolytica peptidase, putative 0.0035 0.0368 0.7262
Brugia malayi Nuclear hormone receptor-like 1 0.0254 0.4604 0.8445
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0085 0.0051
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0049 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0052 0.0052
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0085 0.0051
Echinococcus granulosus geminin 0.0195 0.3466 0.3443
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0184 0.015
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1067 0.1922
Leishmania major trypanothione reductase 0.0107 0.1749 0.3179
Brugia malayi metallopeptidase family M24 containing protein 0.0035 0.0368 0.0667
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0085 0.0051
Loa Loa (eye worm) initiation factor 2-associated protein 0.0035 0.0368 0.0667
Echinococcus granulosus lamin 0.0031 0.0282 0.0248
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0147
Plasmodium falciparum glutathione reductase 0.0037 0.0401 0.0653
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0049 0.0014
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.1004 0.0973
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0401 0.0653
Echinococcus granulosus methionyl aminopeptidase 2 0.0035 0.0368 0.0335
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0035 0.0368 0.0592
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0147
Brugia malayi hypothetical protein 0.003 0.0276 0.0496
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0401 0.064
Echinococcus multilocularis geminin 0.0195 0.3466 0.3443
Echinococcus granulosus Proliferation associated protein 2G4 0.0035 0.0368 0.0335
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0147
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0052 0.0007
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0076 0.1164 0.2292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1067 0.1922
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0085 0.0147
Loa Loa (eye worm) methionine aminopeptidase type I 0.0298 0.5451 1
Mycobacterium tuberculosis Probable oxidoreductase 0.027 0.4917 0.9664
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0085 0.0147
Onchocerca volvulus 0.0035 0.0368 0.0657
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0035 0.0368 0.0592
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0106 0.0151
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0345 0.0312
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0035 0.0368 0.0527
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0049 0.008
Chlamydia trachomatis methionine aminopeptidase 0.0279 0.5085 1
Toxoplasma gondii peptidase D, putative 0.0035 0.0368 0.0675
Giardia lamblia Xaa-Pro dipeptidase 0.0035 0.0368 0.8884
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0035 0.0368 0.0657
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0756 0.0724
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0401 0.0695

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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