Detailed information for compound 1704549

Basic information

Technical information
  • TDR Targets ID: 1704549
  • Name: 5-[4-(2H-tetrazol-5-yl)phenyl]-2H-tetrazole
  • MW: 214.187 | Formula: C8H6N8
  • H donors: 2 H acceptors: 6 LogP: 0.35 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: n1[nH]nc(n1)c1ccc(cc1)c1n[nH]nn1
  • InChi: 1S/C8H6N8/c1-2-6(8-11-15-16-12-8)4-3-5(1)7-9-13-14-10-7/h1-4H,(H,9,10,13,14)(H,11,12,15,16)
  • InChiKey: TUSPQFBMQKZVAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[4-(2H-1,2,3,4-tetrazol-5-yl)phenyl]-2H-1,2,3,4-tetrazole
  • 6926-49-4
  • NSC133356

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0196 0.1836 0.1836
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0966 1 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0966 1 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.1673 0.1673
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0966 1 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1673 0.1673
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0315 0.3099 0.3099
Echinococcus multilocularis muscleblind protein 0.018 0.1673 0.1673
Schistosoma mansoni sterol O-acyltransferase 1 0.0217 0.2061 0.2061
Loa Loa (eye worm) hypothetical protein 0.005 0.0294 0.0294
Brugia malayi hypothetical protein 0.0025 0.0022 0.0022
Loa Loa (eye worm) TAR-binding protein 0.0189 0.1761 0.1761
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0294 0.0294
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0022
Onchocerca volvulus 0.0022 0 0.5
Loa Loa (eye worm) RNA binding protein 0.0189 0.1761 0.1761
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1761 0.1761
Echinococcus granulosus tar DNA binding protein 0.0189 0.1761 0.1761
Schistosoma mansoni retinoic acid receptor RXR 0.0315 0.3099 0.3099
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.018 0.1673 0.1673
Echinococcus granulosus muscleblind protein 0.018 0.1673 0.1673
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0966 1 1
Echinococcus granulosus sterol O acyltransferase 1 0.0217 0.2061 0.2061
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0294 0.0294
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1761 0.1761
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.0217 0.2061 0.2061
Echinococcus multilocularis sterol O acyltransferase 1 0.0217 0.2061 0.2061
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0022 0.5
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0966 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0022 0.5
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.0034 0.0126 0.0126
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0966 1 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0966 1 1
Echinococcus granulosus transcription factor Dp 1 0.0559 0.5688 0.5688
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0022 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0 0.5
Brugia malayi Muscleblind-like protein 0.018 0.1673 0.1673
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0022 0.5
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0966 1 0.5
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0303 0.2973 0.2973
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0966 1 1
Echinococcus multilocularis tar DNA binding protein 0.0189 0.1761 0.1761
Brugia malayi TAR-binding protein 0.0189 0.1761 0.1761
Echinococcus multilocularis transcription factor Dp 1 0.0559 0.5688 0.5688
Brugia malayi RNA binding protein 0.0189 0.1761 0.1761
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0126 0.0126
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.1761 0.1761
Schistosoma mansoni hypothetical protein 0.0034 0.0126 0.0126
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.1761 0.1761
Onchocerca volvulus Bile acid receptor homolog 0.0022 0 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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