Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1426 | 0.8229 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0872 | 0.3431 | 0.4169 |
Brugia malayi | Kringle domain containing protein | 0.0872 | 0.3431 | 0.4169 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.163 | 1 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0872 | 0.3431 | 0.5808 |
Onchocerca volvulus | 0.0949 | 0.4099 | 0.4981 | |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0872 | 0.3431 | 0.5808 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1158 | 0.5907 | 1 |
Brugia malayi | hypothetical protein | 0.0551 | 0.0645 | 0.0783 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0872 | 0.3431 | 0.4169 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.163 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1158 | 0.5907 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0872 | 0.3431 | 0.4169 |
Loa Loa (eye worm) | hypothetical protein | 0.0872 | 0.3431 | 0.4169 |
Echinococcus granulosus | thymidylate synthase | 0.1158 | 0.5907 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1158 | 0.5907 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0872 | 0.3431 | 0.2978 |
Mycobacterium ulcerans | thymidylate synthase | 0.1158 | 0.5907 | 1 |
Onchocerca volvulus | 0.1426 | 0.8229 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1426 | 0.8229 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.1158 | 0.5907 | 0.7178 |
Onchocerca volvulus | 0.1158 | 0.5907 | 0.7178 | |
Brugia malayi | thymidylate synthase | 0.1158 | 0.5907 | 0.7178 |
Brugia malayi | Trypsin family protein | 0.1426 | 0.8229 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1426 | 0.8229 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1426 | 0.8229 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.163 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1158 | 0.5907 | 0.7178 |
Onchocerca volvulus | 0.0872 | 0.3431 | 0.4169 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.163 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0551 | 0.0645 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.