Detailed information for compound 1704654

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 360.447 | Formula: C20H28N2O4
  • H donors: 1 H acceptors: 2 LogP: 3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(C(=O)N1CCC1(C)C(=O)Nc1ccc2c(c1)OCCO2)(C)C
  • InChi: 1S/C20H28N2O4/c1-5-8-19(2,3)18(24)22-10-9-20(22,4)17(23)21-14-6-7-15-16(13-14)26-12-11-25-15/h6-7,13H,5,8-12H2,1-4H3,(H,21,23)
  • InChiKey: QEVYGZKLNIIBTM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi subtilisin peptidase 0.006 0.0089 0.0378
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0152 0.0139
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0035 0.0037
Onchocerca volvulus 0.006 0.0089 0.007
Toxoplasma gondii subtilisin SUB9 0.006 0.0089 0.1862
Toxoplasma gondii subtilisin SUB6 0.006 0.0089 0.1862
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0035 0.001
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0099 0.0242 0.0292
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0084 0.0182 0.481
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0099 0.0242 0.0292
Mycobacterium leprae Possible secreted protease 0.006 0.0089 0.1351
Schistosoma mansoni integrin alpha-ps 0.0069 0.0125 0.0192
Brugia malayi EGF-like domain containing protein 0.006 0.0087 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Echinococcus multilocularis protein jagged 2 0.006 0.0087 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Onchocerca volvulus Prolyl endopeptidase homolog 0.0144 0.0416 0.956
Schistosoma mansoni hypothetical protein 0.0064 0.0103 0.0155
Toxoplasma gondii prolyl endopeptidase 0.0144 0.0416 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0152 0.0449 0.0436
Echinococcus granulosus epidermal growth factor receptor 0.0056 0.0072 0.006
Echinococcus granulosus neuroendocrine convertase 2 0.0888 0.3336 0.4521
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0925 0.2673
Echinococcus multilocularis Furin 1 0.0334 0.1162 0.1549
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0057 0.0076 0.0871
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0099 0.0242 0.0395
Trypanosoma brucei prolyl endopeptidase 0.0144 0.0416 1
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0099 0.0242 0.0292
Loa Loa (eye worm) hypothetical protein 0.0554 0.2027 0.2027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.1162 0.3428
Loa Loa (eye worm) hypothetical protein 0.0164 0.0496 0.0496
Echinococcus multilocularis nmda type glutamate receptor 0.011 0.0284 0.0349
Loa Loa (eye worm) hypothetical protein 0.0045 0.0028 0.0028
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0099 0.0242 0.4877
Toxoplasma gondii subtilisin SUB11 0.006 0.0089 0.1862
Leishmania major eukaryotic initiation factor 4a, putative 0.0099 0.0242 0.4877
Toxoplasma gondii subtilisin SUB10 0.006 0.0089 0.1862
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0144 0.0416 0.0696
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0028 0.0025
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0144 0.0416 0.0696
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0925 0.2673
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0035 0.001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0035 0.001
Echinococcus granulosus fibrillin 1 0.006 0.0087 0.008
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0089 0.0008
Trypanosoma cruzi prolyl endopeptidase 0.0144 0.0416 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0079 0.0162 0.4065
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0063 0.0099 0.172
Loa Loa (eye worm) hypothetical protein 0.0099 0.0242 0.0242
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Loa Loa (eye worm) reprolysin 0.0045 0.0028 0.0028
Giardia lamblia Furin precursor putative serine protease 0.0273 0.0925 0.4589
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0067 0.0115 0.114
Schistosoma mansoni hypothetical protein 0.0273 0.0925 0.1577
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0162 0.4065
Echinococcus granulosus adam 0.0118 0.0317 0.0395
Schistosoma mansoni protein kinase 0.0258 0.0863 0.1471
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.006 0.0089 0.1351
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0119 0.0321 0.8878
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0099 0.0242 0.0395
Onchocerca volvulus 0.0076 0.0152 0.19
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0035 0.001
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0079 0.0162 0.4065
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0067 0.0115 0.114
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0067 0.0115 0.114
Loa Loa (eye worm) hypothetical protein 0.0397 0.1409 0.1409
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.1162 0.3428
Toxoplasma gondii subtilisin SUB12 0.006 0.0089 0.1862
Mycobacterium tuberculosis Probable thioesterase TesA 0.0068 0.012 0.264
Mycobacterium ulcerans thioesterase TesA 0.0068 0.012 0.2493
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.006 0.0089 0.1691
Loa Loa (eye worm) hypothetical protein 0.0144 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.1413 0.5396 0.5396
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0059 0.0083 0.0119
Leishmania major eukaryotic initiation factor 4a, putative 0.0099 0.0242 0.4877
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0089 0.0075
Loa Loa (eye worm) hypothetical protein 0.006 0.0089 0.0089
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.006 0.0089 0.1351
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0079 0.0162 0.0148
Loa Loa (eye worm) hypothetical protein 0.0041 0.0014 0.0014
Brugia malayi proprotein convertase 2 0.0888 0.3336 0.3327
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Schistosoma mansoni glutamate receptor NMDA 0.026 0.0873 0.1488
Echinococcus multilocularis adam 0.0118 0.0317 0.0395
Echinococcus granulosus glutamate receptor 2 0.0047 0.0035 0.001
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0859 0.3222 0.4364
Loa Loa (eye worm) hypothetical protein 0.0234 0.0769 0.0769
Schistosoma mansoni furin-1 (S08 family) 0.0615 0.2264 0.3896
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0068 0.0068
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0099 0.0242 0.085
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0099 0.0242 0.0495
Echinococcus granulosus fibrillin 2 0.006 0.0087 0.008
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.006 0.0089 0.1351
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0064 0.0103 0.213
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0079 0.0162 0.3946
Loa Loa (eye worm) integrin alpha pat-2 0.0459 0.1652 0.1652
Mycobacterium ulcerans polyketide synthase 0.0079 0.0162 0.4065
Echinococcus multilocularis fibrillin 1 0.006 0.0087 0.008
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.006 0.0089 0.0076
Loa Loa (eye worm) proprotein convertase 2 0.0334 0.1162 0.1162
Mycobacterium leprae Probable polyketide synthase Pks1 0.0084 0.0182 0.481
Brugia malayi celfurPC protein 0.114 0.4324 0.4316
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0084 0.0182 0.4566
Toxoplasma gondii subtilisin SUB4 0.006 0.0089 0.1862
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0028 0.0025
Loa Loa (eye worm) endoprotease bli-4 0.1413 0.5396 0.5396
Toxoplasma gondii subtilisin SUB7 0.006 0.0089 0.1862
Schistosoma mansoni integrin beta subunit 0.1513 0.5789 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.1162 0.3428
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0925 0.2673
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0099 0.0242 0.5667
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0068 0.0094
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0079 0.0164 0.3997
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0925 0.2673
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Chlamydia trachomatis glutamine binding protein 0.0079 0.0163 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.1162 0.3428
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0059 0.0083 0.1494
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0079 0.0163 0.3966
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0273 0.0925 0.2673
Trichomonas vaginalis hypothetical protein 0.0273 0.0925 0.2673
Trypanosoma brucei subtilisin peptidase 0.006 0.0089 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0089 0.0008
Echinococcus granulosus integrin alpha 3 0.0228 0.0747 0.0982
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0057 0.0076 0.1292
Toxoplasma gondii subtilisin SUB2 0.006 0.0089 0.1862
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0089 0.0008
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0079 0.0162 0.3946
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0079 0.0162 0.3946
Onchocerca volvulus 0.0142 0.0411 0.9421
Brugia malayi Subtilase family protein 0.006 0.0089 0.0076
Loa Loa (eye worm) hypothetical protein 0.0069 0.0125 0.0125
Echinococcus multilocularis prolyl endopeptidase 0.0144 0.0416 0.053
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0089 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0859 0.3222 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0076 0.0152 0.3647
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0226 0.074 0.074
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Mycobacterium tuberculosis Probable peptidase 0.0057 0.0076 0.1292
Brugia malayi Kelch motif family protein 0.0403 0.1435 0.1423
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0403 0.1435 0.1435
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0068 0.0054
Schistosoma mansoni hypothetical protein 0.0055 0.0068 0.0094
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0258 0.0863 0.1141
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0162 0.4065
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0079 0.0163 0.4089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.006 0.0089 0.1691
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0925 0.2673
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0925 0.2673
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0099 0.0242 0.4877
Echinococcus granulosus eukaryotic initiation factor 4A 0.0099 0.0242 0.0292
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0859 0.3222 1
Echinococcus granulosus nmda type glutamate receptor 0.011 0.0284 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0925 0.2673
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Echinococcus multilocularis neuroendocrine convertase 2 0.0888 0.3336 0.4521
Loa Loa (eye worm) fatty acid synthase 0.0081 0.0169 0.0169
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.011 0.0284 0.0349
Toxoplasma gondii type I fatty acid synthase, putative 0.0084 0.0182 0.4168
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0099 0.0242 0.0495
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0068 0.012 0.2493
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.0035 0.001
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.026 0.0873 0.1154
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0226 0.074 0.0727
Schistosoma mansoni tyrosine kinase 0.0056 0.0072 0.0101
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.0035 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0273 0.0925 0.2673
Echinococcus multilocularis integrin beta 2 0.191 0.7345 1
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0225 0.0735 0.0722
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.006 0.0089 0.1691
Loa Loa (eye worm) hypothetical protein 0.006 0.0087 0.0087
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.006 0.0089 0.0131
Echinococcus granulosus integrin alpha ps 0.0133 0.0376 0.0475
Brugia malayi endoprotease bli-4 precursor 0.1413 0.5396 0.539
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0068 0.0094
Echinococcus granulosus integrin alpha ps 0.0064 0.0103 0.0102
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.006 0.0089 0.0083
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.006 0.0089 0.0083
Brugia malayi neuroendocrine convertase 1 precursor 0.0888 0.3336 0.3327
Toxoplasma gondii hypothetical protein 0.006 0.0087 0.1802
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0035 0.001
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0099 0.0242 0.4877
Loa Loa (eye worm) hypothetical protein 0.0135 0.038 0.038
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0162 0.4065
Schistosoma mansoni integrin alpha-ps 0.0133 0.0376 0.0626
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0099 0.0242 0.0495
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.1162 0.3428
Echinococcus multilocularis 0.114 0.4324 0.5871
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0925 0.2673
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Schistosoma mansoni protein kinase 0.0258 0.0863 0.1471
Loa Loa (eye worm) hypothetical protein 0.006 0.0089 0.0089
Mycobacterium leprae Polyketide synthase Pks13 0.0119 0.0321 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0258 0.0863 0.1141
Mycobacterium ulcerans polyketide synthase Pks13 0.0119 0.0321 1
Echinococcus granulosus membrane bound transcription factor site 1 0.006 0.0089 0.0083
Echinococcus multilocularis integrin alpha ps 0.0133 0.0376 0.0475
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0068 0.0054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Loa Loa (eye worm) hypothetical protein 0.006 0.0087 0.0087
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.006 0.0089 0.0131
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0021
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0057 0.0076 0.0871
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0273 0.0925 0.2673
Schistosoma mansoni hypothetical protein 0.0055 0.0068 0.0094
Echinococcus granulosus Furin 1 0.0334 0.1162 0.1549
Echinococcus multilocularis epidermal growth factor receptor 0.0056 0.0072 0.006
Loa Loa (eye worm) hypothetical protein 0.0055 0.0068 0.0068
Echinococcus granulosus glutamate NMDA receptor subunit 0.026 0.0873 0.1154
Loa Loa (eye worm) TK/EGFR protein kinase 0.0056 0.0072 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.1162 0.3428
Schistosoma mansoni site-1 peptidase (S08 family) 0.006 0.0089 0.0131
Echinococcus granulosus integrin beta 2 0.191 0.7345 1
Mycobacterium ulcerans polyketide synthase 0.0084 0.0182 0.481
Brugia malayi EGF-like domain containing protein 0.006 0.0087 0.0073
Brugia malayi Furin-like cysteine rich region family protein 0.0056 0.0072 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Loa Loa (eye worm) hypothetical protein 0.006 0.0087 0.0087
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.006 0.0089 0.1691
Treponema pallidum ATP-dependent RNA helicase 0.0099 0.0242 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0068 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0925 0.2673
Echinococcus granulosus furin 0.1413 0.5396 0.7336
Leishmania major subtilisin-like serine peptidase 0.006 0.0089 0.0378
Echinococcus granulosus prolyl endopeptidase 0.0144 0.0416 0.053
Brugia malayi hypothetical protein 0.0059 0.0083 0.0069
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.0081 0.1651
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0035 0.001
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0084 0.0182 0.4566
Brugia malayi hypothetical protein 0.0397 0.1409 0.1397
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0925 0.2673
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0089 0.0075
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0076 0.0152 0.0152
Loa Loa (eye worm) integrin beta-2 0.2586 1 1
Onchocerca volvulus Fatty acid synthase homolog 0.0147 0.0431 1
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.006 0.0089 0.1351
Echinococcus multilocularis fibrillin 2 0.006 0.0087 0.008
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0099 0.0242 0.6435
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0084 0.0182 0.481
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0925 0.2673
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Plasmodium falciparum eukaryotic initiation factor 4A 0.0099 0.0242 1
Schistosoma mansoni hypothetical protein 0.0055 0.0068 0.0094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Plasmodium vivax RNA helicase-1, putative 0.0099 0.0242 1
Giardia lamblia High cysteine membrane protein Group 2 0.0525 0.1912 1
Brugia malayi EGF-like domain containing protein 0.006 0.0087 0.0073
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0084 0.0182 0.481
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0079 0.0163 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0084 0.0182 0.481
Schistosoma mansoni site-1 peptidase (S08 family) 0.006 0.0089 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0089 0.0008
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.006 0.0089 0.1351
Loa Loa (eye worm) subtilase 0.006 0.0089 0.0089
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0119 0.0321 0.8878
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0063 0.0099 0.172
Echinococcus multilocularis integrin alpha ps 0.0133 0.0376 0.0475
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1413 0.5396 0.932
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0859 0.3222 0.4364
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0144 0.0416 1
Brugia malayi prolyl oligopeptidase family protein 0.0144 0.0416 0.0403
Loa Loa (eye worm) hypothetical protein 0.0064 0.0103 0.0103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0089 0.0089
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0099 0.0242 0.4508
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0035 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Toxoplasma gondii subtilisin SUB5 0.006 0.0089 0.1862
Schistosoma mansoni integrin alpha 0.0297 0.102 0.1742
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0053 0.0061 0.1147
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.006 0.0089 0.0378
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0099 0.0242 0.5
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0688 0.2552 0.345
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0334 0.1162 0.1988
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0084 0.0182 0.4566
Mycobacterium ulcerans thioesterase 0.0068 0.012 0.2493
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0063 0.0099 0.172
Brugia malayi eukaryotic initiation factor 4A 0.0099 0.0242 0.0228
Loa Loa (eye worm) hypothetical protein 0.006 0.0087 0.0087
Toxoplasma gondii subtilisin SUB1 0.006 0.0089 0.1862
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0079 0.0162 0.4065
Brugia malayi Integrin alpha pat-2 precursor 0.0297 0.102 0.1007
Echinococcus multilocularis integrin alpha 3 0.0228 0.0747 0.0982
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Loa Loa (eye worm) hypothetical protein 0.0225 0.0735 0.0735
Toxoplasma gondii subtilisin SUB8 0.006 0.0089 0.1862
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.006 0.0089 0.0076
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0129 0.0357 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0079 0.0164 0.3997
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0688 0.2552 0.345
Echinococcus multilocularis integrin alpha ps 0.0064 0.0103 0.0102
Schistosoma mansoni protein kinase 0.0258 0.0863 0.1471
Brugia malayi EGF-like domain containing protein 0.006 0.0087 0.0073
Echinococcus multilocularis membrane bound transcription factor site 1 0.006 0.0089 0.0083
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0089 0.0008

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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