Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0181 | 0.3561 | 0.3579 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0356 | 0.8533 | 0.8576 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0179 | 0.3493 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0179 | 0.3493 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0056 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0406 | 0.995 | 1 |
Echinococcus multilocularis | geminin | 0.0172 | 0.331 | 0.3327 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3561 | 0.4173 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0179 | 0.3493 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0406 | 0.995 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0179 | 0.3493 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0179 | 0.3493 | 0.6784 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0179 | 0.3493 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.331 | 0.331 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0356 | 0.8533 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0179 | 0.3493 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0356 | 0.8533 | 1 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0378 | 0.9149 | 0.9149 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0179 | 0.3493 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0406 | 0.995 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0237 | 0.5149 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0056 | 0 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0356 | 0.8533 | 0.8533 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.48 | 0.5625 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0056 | 0 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0378 | 0.9149 | 0.9195 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0378 | 0.9149 | 0.9195 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0056 | 0 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0056 | 0 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0056 | 0 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0406 | 0.995 | 1 |
Echinococcus granulosus | geminin | 0.0172 | 0.331 | 0.3327 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0356 | 0.8533 | 0.8576 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0406 | 0.995 | 0.995 |
Trichomonas vaginalis | hypothetical protein | 0.0179 | 0.3493 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.331 | 0.331 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0056 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0406 | 0.995 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0406 | 0.995 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0406 | 0.995 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0356 | 0.8533 | 0.8576 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0406 | 0.995 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.