Detailed information for compound 170485

Basic information

Technical information
  • TDR Targets ID: 170485
  • Name: [(2R,3S,5R)-5-(5-benzyl-2,4-dioxopyrimidin-1- yl)-3-hydroxyoxolan-2-yl]methyl phosphate
  • MW: 396.289 | Formula: C16H17N2O8P--
  • H donors: 2 H acceptors: 6 LogP: -1.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1C[C@@H](O[C@@H]1COP(=O)([O-])[O-])n1cc(Cc2ccccc2)c(=O)[nH]c1=O
  • InChi: 1S/C16H19N2O8P/c19-12-7-14(26-13(12)9-25-27(22,23)24)18-8-11(15(20)17-16(18)21)6-10-4-2-1-3-5-10/h1-5,8,12-14,19H,6-7,9H2,(H,17,20,21)(H2,22,23,24)/p-2/t12-,13+,14+/m0/s1
  • InChiKey: ZJPWXRDQGVJJPT-BFHYXJOUSA-L  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(2R,3S,5R)-5-(5-benzyl-2,4-dioxo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphate
  • [(2R,3S,5R)-5-(5-benzyl-2,4-dioxo-1-pyrimidinyl)-3-hydroxy-2-tetrahydrofuranyl]methyl phosphate
  • [(2R,3S,5R)-5-[2,4-dioxo-5-(phenylmethyl)pyrimidin-1-yl]-3-hydroxy-oxolan-2-yl]methyl phosphate
  • [(2R,3S,5R)-5-(5-benzyl-2,4-diketo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphate
  • [(2R,3S,5R)-5-[2,4-dioxo-5-(phenylmethyl)pyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methyl phosphate
  • [(2R,3S,5R)-5-[2,4-dioxo-5-(phenylmethyl)pyrimidin-1-yl]-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphate
  • [(2R,3S,5R)-5-[2,4-dioxo-5-(phenylmethyl)-1-pyrimidinyl]-3-hydroxy-2-tetrahydrofuranyl]methyl phosphate
  • [(2R,3S,5R)-5-[5-(benzyl)-2,4-diketo-pyrimidin-1-yl]-3-hydroxy-tetrahydrofuran-2-yl]methyl phosphate
  • AIDS348770
  • 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-5-O-phosphono-b-D-erythro-pentofuranosyl)-5-(phenylmethyl)-, ion(2-)
  • AIDS-348770

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0104 0.0159 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.0763 0.0905
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0191 0.1265 0.1345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0602 0.649 0.7694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0479 0.4929 0.5843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.0763 0.0905
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0104 0.0159 0.5
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0755 0.8435 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0477 0.4897 0.5805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0259 0.2127 0.2521
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0324 0.2962 0.2943
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0477 0.4897 0.5729
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0104 0.0159 0.0159
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0259 0.2127 0.2521
Entamoeba histolytica hypothetical protein 0.0151 0.0763 0.074
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0571 0.6098 0.7179
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0709 0.7854 0.9298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0397 0.3883 0.4603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.5646 0.6693
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0259 0.2127 0.2069
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0755 0.8435 0.8411
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0755 0.8435 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0536 0.5646 1
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0104 0.0159 0.001
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0104 0.0159 0.5
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0104 0.0159 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0103 0.0151 0.0178
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0755 0.8435 1
Trichomonas vaginalis fk506-binding protein, putative 0.0104 0.0159 0.0188
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0259 0.2127 0.2385
Brugia malayi FAT domain containing protein 0.0107 0.0201 0.0052
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0855 0.9703 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0104 0.0159 0.0159
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0709 0.7854 0.9298
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0103 0.0151 0.0178
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0259 0.2127 0.2385
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0259 0.2127 0.2069
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0755 0.8435 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0463 0.4727 0.5604
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0709 0.7854 0.9298
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0191 0.1265 0.1345
Loa Loa (eye worm) phosphatidylinositol 3 0.0131 0.0502 0.0502
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0477 0.4897 0.5805
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0755 0.8435 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.6091 0.7221
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0104 0.0159 0.001
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0151 0.0763 0.074
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0104 0.0159 0.0015
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0104 0.0159 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0397 0.389 0.4611
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0151 0.0763 0.0622
Echinococcus multilocularis fk506 binding protein 0.0755 0.8435 0.8672
Loa Loa (eye worm) hypothetical protein 0.0878 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0201 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0397 0.389 0.4611
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0259 0.2127 0.2385
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0259 0.2127 0.2006
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0855 0.9703 1
Schistosoma mansoni immunophilin 0.0651 0.7114 0.729
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0104 0.0159 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0397 0.3883 0.4603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0259 0.2127 0.2521
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0191 0.1265 0.1132
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0104 0.0159 0.0188
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0238 0.186 0.2063
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0571 0.6098 0.7179
Echinococcus granulosus serine protein kinase ATM 0.0151 0.0763 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0432 0.4335 0.5139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0428 0.4282 0.5077
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0709 0.7854 0.9298
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0755 0.8435 0.8672
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0755 0.8435 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0325 0.2974 0.2867
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0755 0.8435 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0255 0.2073 0.2313
Schistosoma mansoni hypothetical protein 0.0104 0.0159 0.0009
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0104 0.0159 0.0009
Loa Loa (eye worm) hypothetical protein 0.0651 0.7114 0.7114
Leishmania major hypothetical protein, conserved 0.0154 0.0793 0.0775
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0104 0.0159 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0159 0.0188
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.0159 0.001
Echinococcus multilocularis serine protein kinase ATM 0.0151 0.0763 0.0641
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0107 0.0201 0.0053
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0104 0.0159 0.0008
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0651 0.7114 0.729
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0755 0.8435 1
Leishmania major peptidylprolyl isomerase-like protein 0.0755 0.8435 1
Toxoplasma gondii FATC domain-containing protein 0.0151 0.0763 0.1115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.7854 0.9311
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.0159 0.001
Echinococcus granulosus FK506 binding protein 2 0.0104 0.0159 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0159 0.0188
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0755 0.8435 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0325 0.2974 0.2956
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0151 0.0763 0.0905
Trichomonas vaginalis PIKK family atypical protein kinase 0.0432 0.4335 0.5139
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0755 0.8435 0.8672
Onchocerca volvulus 0.0104 0.0159 0.5
Trypanosoma cruzi target of rapamycin kinase 3 0.0571 0.6098 0.7229
Loa Loa (eye worm) hypothetical protein 0.0855 0.9705 0.9705
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0417 0.4134 0.4808
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0104 0.0159 0.0015
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0325 0.2974 0.2956
Trichomonas vaginalis PIKK family atypical protein kinase 0.0397 0.389 0.4611
Onchocerca volvulus 0.0104 0.0159 0.5
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0151 0.0763 0.0641
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0755 0.8435 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0104 0.0159 0.0008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0191 0.1265 0.1345
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0342 0.3188 0.3779
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.0159 0.0188
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0103 0.0151 0.0178
Loa Loa (eye worm) hypothetical protein 0.0167 0.0965 0.0965
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0151 0.0763 0.0622
Loa Loa (eye worm) hypothetical protein 0.0151 0.0763 0.0763
Echinococcus multilocularis 0.0104 0.0159 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0104 0.0159 0.001
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0755 0.8435 0.8435
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0104 0.0159 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.5646 0.6693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.5646 0.6693
Entamoeba histolytica protein kinase rad3, putative 0.0151 0.0763 0.074
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0855 0.9703 1
Schistosoma mansoni immunophilin 0.0755 0.8435 0.8672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0259 0.2127 0.2521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.5646 0.6693
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0755 0.8435 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0107 0.0201 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.5646 0.6693
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0104 0.0159 0.001
Trichomonas vaginalis fk506-binding protein, putative 0.0755 0.8435 1
Trypanosoma cruzi hypothetical protein, conserved 0.0094 0.0029 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.6091 0.7221
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0651 0.7114 0.729
Loa Loa (eye worm) hypothetical protein 0.0151 0.0761 0.0761
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0755 0.8435 1
Trichomonas vaginalis fk506 binding protein, putative 0.0104 0.0159 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.0763 0.0905
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0755 0.8435 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0389 0.3782 0.4384
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0191 0.1265 0.15
Loa Loa (eye worm) hypothetical protein 0.0138 0.0594 0.0594
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0709 0.7854 0.7821
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.0159 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.5646 0.6693
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0151 0.0763 0.0641
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0709 0.7854 0.8064
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0337 0.312 0.3585
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0259 0.2127 0.2521
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0755 0.8435 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0477 0.4897 0.4819
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0151 0.0763 0.0905
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.6091 0.7221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0428 0.4282 0.5077
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0191 0.1265 0.15
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0709 0.7854 0.9298
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0103 0.0151 0.0178
Giardia lamblia GTOR 0.0709 0.7854 0.9298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0259 0.2127 0.2521
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0477 0.4897 0.5805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.6091 0.7221
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0709 0.7854 0.9311
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0104 0.0159 0.0159
Entamoeba histolytica hypothetical protein 0.0389 0.3782 0.4384
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.0159 0.001
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0755 0.8435 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0378 0.3645 0.3547
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0104 0.0159 0.0188
Schistosoma mansoni fk506 binding protein 0.0104 0.0159 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0965 0.1144
Schistosoma mansoni fkbp-rapamycin associated protein 0.0151 0.0763 0.0641
Leishmania major phosphatidylinositol 3-kinase, putative 0.0259 0.2127 0.2385
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0709 0.7854 0.9298
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0755 0.8435 0.8411
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0103 0.0151 0.0178
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0167 0.0965 0.1482
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.0159 0.0188
Loa Loa (eye worm) phosphatidylinositol 3 0.0767 0.8589 0.8589
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0103 0.0151 0.0151
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0429 0.4285 0.4328
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0151 0.0763 0.074
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0324 0.2962 0.2943
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0191 0.1265 0.15
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0306 0.2728 0.3111
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0709 0.7854 0.8064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0397 0.3883 0.4603
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0191 0.1265 0.15
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.0159 0.001
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0104 0.0159 0.0008
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0104 0.0159 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0397 0.389 0.4611
Loa Loa (eye worm) phosphatidylinositol 3 0.0259 0.2127 0.2127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.7854 0.9311
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0131 0.0502 0.0595
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0709 0.7854 0.9311
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.0159 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.7854 0.9311
Trichomonas vaginalis fk506-binding protein, putative 0.0104 0.0159 0.0188
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0477 0.4897 0.5805
Schistosoma mansoni hypothetical protein 0.0107 0.0201 0.0053
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0191 0.1265 0.1167
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0477 0.4897 0.5805
Loa Loa (eye worm) FKBP5 protein 0.0755 0.8435 0.8435
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0342 0.3188 0.3779
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0755 0.8435 0.8672
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0148 0.0716 0.0673
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0151 0.0763 0.0641
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0259 0.2127 0.2069
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0755 0.8435 0.8672
Loa Loa (eye worm) hypothetical protein 0.0104 0.0159 0.0159
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0709 0.7854 0.8064
Loa Loa (eye worm) phosphatidylinositol 3 0.0709 0.7854 0.7854
Trichomonas vaginalis PIKK family atypical protein kinase 0.0428 0.4282 0.5077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0198 0.1357 0.1609
Trichomonas vaginalis immunophilin, putative 0.0755 0.8435 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0201 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.5646 0.6693
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0104 0.0159 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0259 0.2127 0.2521
Leishmania major fk506-binding protein 1-like protein 0.0755 0.8435 1
Schistosoma mansoni immunophilin 0.0755 0.8435 0.8672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0571 0.6091 0.7221
Loa Loa (eye worm) hypothetical protein 0.0325 0.2974 0.2974
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0755 0.8435 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 28 uM Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis ChEMBL. 12941330

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.