Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | proteasome subunit beta type, putative | 0.014 | 0.2837 | 0.2837 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0253 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0253 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.014 | 0.2837 | 0.2837 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0253 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.014 | 0.2837 | 0.5 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.014 | 0.2837 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.014 | 0.2837 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0253 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.014 | 0.2837 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.014 | 0.2837 | 0.2837 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.014 | 0.2837 | 0.2837 |
Toxoplasma gondii | kringle domain-containing protein | 0.0253 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | 0.0253 | 1 | 0.5 | |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.014 | 0.2837 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0253 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.014 | 0.2837 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0253 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0253 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.014 | 0.2837 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.014 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0253 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain | 0.014 | 0.2837 | 0.2837 |
Brugia malayi | Kringle domain containing protein | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.014 | 0.2837 | 0.2837 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.014 | 0.2837 | 0.2837 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.