Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis | 4'-phosphopantetheinyl transferase ffp | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Onchocerca volvulus | 4'-phosphopantetheinyl transferase ffp | 224 aa | 186 aa | 26.3 % | |
Entamoeba histolytica | hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 198 aa | 28.3 % |
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Trichomonas vaginalis | conserved hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 197 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0329 | 0.0345 | 0.0345 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2383 | 0.4454 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2383 | 0.4454 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.5154 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2383 | 0.4454 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.5154 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.5154 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2383 | 0.4454 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0329 | 0.0345 | 0.0345 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.5154 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2383 | 0.4454 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2383 | 0.4454 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.5154 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.5154 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0157 | 0 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.5154 | 1 | 1 |
Onchocerca volvulus | 0.0329 | 0.0345 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.5154 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.5154 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PubChem BioAssay. Gel-Based Assay for Inhibitos of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase): Chemistry Optimization Follow up. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.