Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B | ChEMBL. | 14695815 |
IC50 (binding) | > 50 uM | Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B | ChEMBL. | 14695815 |
IC50 (functional) | > 500 uM | Inhibitory concentration in cap-dependent RNA polymerase assay with influenza A polymerase | ChEMBL. | 12646026 |
IC50 (functional) | > 500 uM | Inhibitory concentration in cap-dependent RNA polymerase assay with influenza A polymerase | ChEMBL. | 12646026 |
IC50 (binding) | > 500 uM | Inhibition of cap 1 ALMV primed Influenza transcriptase | ChEMBL. | 7695269 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.