Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.359 | 0.359 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0316 | 0.0316 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0316 | 0.0316 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.5122 | 0.5122 |
Brugia malayi | RNA binding protein | 0.0066 | 0.5122 | 0.5122 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.359 | 0.6812 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0316 | 0.0316 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.359 | 0.6812 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5122 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0316 | 0.0316 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5122 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0316 | 0.0316 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.359 | 0.359 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.5122 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.359 | 0.6812 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 1 | 1 |
Brugia malayi | Smad1 | 0.0008 | 0.0316 | 0.0316 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.5122 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.359 | 0.6812 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.5122 | 0.5122 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5122 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.359 | 0.6812 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5122 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.359 | 0.6812 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.359 | 0.6812 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.5122 | 0.5122 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.5122 | 0.5122 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.5122 | 0.5122 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5122 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.