Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | steroid hormone receptor | 0.0016 | 0.0251 | 0.0251 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0311 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0013 | 0.0143 | 0.0143 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0016 | 0.0251 | 0.0251 |
Schistosoma mansoni | high-affinity choline transporter | 0.0311 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.831 | 0.831 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0013 | 0.0143 | 0.0143 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0143 | 0.0143 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.004 | 0.1058 | 0.1058 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0016 | 0.0251 | 0.0251 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0013 | 0.0143 | 0.0143 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0034 | 0.0853 | 0.0853 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0013 | 0.0143 | 0.0143 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0016 | 0.0251 | 0.0251 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0251 | 0.0251 |
Echinococcus granulosus | solute carrier family 5 | 0.0034 | 0.0853 | 0.0853 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0143 | 0.0143 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0016 | 0.0251 | 0.0251 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0016 | 0.0251 | 0.0251 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.008 | 0.2376 | 0.2376 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0107 | 0.325 | 0.325 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0034 | 0.0853 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0034 | 0.0853 | 0.0853 |
Echinococcus multilocularis | solute carrier family 5 | 0.0034 | 0.0853 | 0.0853 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.008 | 0.2376 | 0.2376 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0013 | 0.0143 | 0.0143 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0028 | 0.0634 | 0.0634 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.008 | 0.2376 | 0.2376 |
Schistosoma mansoni | nuclear hormone receptor | 0.0016 | 0.0251 | 0.0251 |
Schistosoma mansoni | thyroid hormone receptor | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0016 | 0.0251 | 0.0251 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.008 | 0.2376 | 0.2376 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0016 | 0.0251 | 0.0251 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0016 | 0.0251 | 0.0251 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.004 | 0.1058 | 0.1058 |
Schistosoma mansoni | sodium/solute symporter | 0.0034 | 0.0853 | 0.0853 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0016 | 0.0251 | 0.0251 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0016 | 0.0251 | 0.0251 |
Onchocerca volvulus | Bile acid receptor homolog | 0.026 | 0.831 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0634 | 0.0634 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.004 | 0.1058 | 0.1058 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0016 | 0.0251 | 0.0251 |
Schistosoma mansoni | inositol transporter | 0.0034 | 0.0853 | 0.0853 |
Brugia malayi | nuclear receptor NHR-88 | 0.0016 | 0.0251 | 0.0251 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0016 | 0.0251 | 0.0251 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0311 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0034 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1058 | 0.1058 |
Echinococcus multilocularis | GPCR, family 2 | 0.0013 | 0.0143 | 0.0143 |
Echinococcus granulosus | FTZ F1 alpha | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Sodium:solute symporter family protein | 0.0034 | 0.0853 | 0.0853 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0143 | 0.0143 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0016 | 0.0251 | 0.0251 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0034 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0107 | 0.325 | 0.325 |
Brugia malayi | nuclear hormone receptor | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.008 | 0.2376 | 0.2376 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.008 | 0.2376 | 0.2376 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0016 | 0.0251 | 0.0251 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0016 | 0.0251 | 0.0251 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | MH2 domain containing protein | 0.0107 | 0.325 | 0.325 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0016 | 0.0251 | 0.0251 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0016 | 0.0251 | 0.0251 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.008 | 0.2376 | 0.2376 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0143 | 0.0143 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0016 | 0.0251 | 0.0251 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0034 | 0.0853 | 0.0853 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0034 | 0.0853 | 0.0853 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0016 | 0.0251 | 0.0251 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.0251 | 0.0251 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0013 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0016 | 0.0251 | 0.0251 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0143 | 0.0143 |
Schistosoma mansoni | coup transcription factor | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0016 | 0.0251 | 0.0251 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0034 | 0.0853 | 0.0853 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.008 | 0.2376 | 0.2376 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0016 | 0.0251 | 0.0251 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0016 | 0.0251 | 0.0251 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0016 | 0.0251 | 0.0251 |
Schistosoma mansoni | inositol transporter | 0.0034 | 0.0853 | 0.0853 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0016 | 0.0251 | 0.0251 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0016 | 0.0251 | 0.0251 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0013 | 0.0143 | 0.0143 |
Brugia malayi | ecdysteroid receptor | 0.026 | 0.831 | 0.831 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0251 | 0.0251 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0634 | 0.0634 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0016 | 0.0251 | 0.0251 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.008 | 0.2376 | 0.2376 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0016 | 0.0251 | 0.0251 |
Onchocerca volvulus | 0.0034 | 0.0853 | 0.0748 | |
Brugia malayi | steroid hormone receptor | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0251 | 0.0251 |
Echinococcus granulosus | GPCR family 2 | 0.0013 | 0.0143 | 0.0143 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.