Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0064 | 0.416 | 0.416 |
Brugia malayi | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Onchocerca volvulus | Peroxidasin homolog | 0.0064 | 0.416 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Onchocerca volvulus | 0.0064 | 0.416 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0064 | 0.416 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0064 | 0.416 | 0.416 |
Onchocerca volvulus | Dual oxidase homolog | 0.0064 | 0.416 | 0.5 |
Onchocerca volvulus | 0.0064 | 0.416 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0064 | 0.416 | 0.416 |
Onchocerca volvulus | Peroxidasin homolog | 0.0064 | 0.416 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Onchocerca volvulus | 0.0064 | 0.416 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0064 | 0.416 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0064 | 0.416 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.416 | 0.416 |
Echinococcus multilocularis | peroxidasin | 0.0064 | 0.416 | 0.416 |
Echinococcus granulosus | peroxidasin | 0.0064 | 0.416 | 0.416 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0064 | 0.416 | 0.416 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.416 | 0.416 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0064 | 0.416 | 0.416 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0064 | 0.416 | 0.416 |
Brugia malayi | Peroxidasin | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Schistosoma mansoni | peroxidasin | 0.0064 | 0.416 | 0.416 |
Brugia malayi | Blistered cuticle protein 3 | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.416 | 0.416 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.