Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7163 | 0.7163 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0005 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0.0005 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0.0005 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0005 | 0.0005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7163 | 0.7163 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.3848 | 0.3848 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.3848 | 0.3848 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3848 | 0.3848 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0005 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0.0005 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7163 | 0.7163 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7163 | 0.7163 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0005 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0.0005 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0.0005 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.3225 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.