Detailed information for compound 1706143

Basic information

Technical information
  • TDR Targets ID: 1706143
  • Name: 4-acetyl-N-(4-piperidin-1-ylsulfonylphenyl)be nzenesulfonamide
  • MW: 422.518 | Formula: C19H22N2O5S2
  • H donors: 1 H acceptors: 5 LogP: 2.12 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCCC1
  • InChi: 1S/C19H22N2O5S2/c1-15(22)16-5-9-18(10-6-16)27(23,24)20-17-7-11-19(12-8-17)28(25,26)21-13-3-2-4-14-21/h5-12,20H,2-4,13-14H2,1H3
  • InChiKey: KKOYNUSWTVIWJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-acetyl-N-[4-(1-piperidylsulfonyl)phenyl]benzenesulfonamide
  • 4-acetyl-N-(4-piperidinosulfonylphenyl)benzenesulfonamide
  • 4-ethanoyl-N-(4-piperidin-1-ylsulfonylphenyl)benzenesulfonamide
  • T5415867
  • ZINC03422967

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Smad4 0.0008 0.0088 0.0078
Brugia malayi hypothetical protein 0.0005 0.0024 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0245
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.2765 0.4768
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0095 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0142 0.0245
Onchocerca volvulus 0.0008 0.0095 0.143
Plasmodium vivax vivapain-2 0.0026 0.0542 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0111 0.0192
Echinococcus multilocularis g-protein coupled receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0008 0.0095 0.0163
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0542 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.001 0.0144 0.0831
Brugia malayi cathepsin B-like cysteine proteinase 0.0141 0.3406 0.5873
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0542 0.0934
Onchocerca volvulus 0.0008 0.0095 0.143
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0542 0.0532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0542 0.4445
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0144 0.0134
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0245
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0142 0.0245
Brugia malayi tailless protein 0.0005 0.001 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0142 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0142 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0095 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0542 0.3941
Schistosoma mansoni neuropeptide receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0542 0.4445
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0095 0.0085
Brugia malayi putative neuropeptide receptor NPR1 0.0008 0.0095 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0142 0.0245
Onchocerca volvulus 0.0008 0.0095 0.143
Entamoeba histolytica cysteine protease, putative 0.0026 0.0542 1
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0095 0.0163
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0095 0.0085
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0008 0.0095 0.0163
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.3406 0.3399
Echinococcus granulosus Smad4 0.0008 0.0088 0.0078
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0144 0.0831
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Brugia malayi cathepsin Z-like cysteine proteinase 0.001 0.0144 0.0248
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0068 0.0058
Schistosoma mansoni neuropeptide f receptor 76f 0.0008 0.0095 0.0085
Schistosoma mansoni biogenic amine receptor 0.0008 0.0095 0.0085
Brugia malayi Serotonin receptor 0.0008 0.0095 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0142 0.0245
Schistosoma mansoni histamine h1 receptor 0.0008 0.0095 0.0085
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Loa Loa (eye worm) TYRA-2 protein 0.0008 0.0095 0.0163
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0142 0.2239
Echinococcus multilocularis cathepsin L 0.001 0.0144 0.0134
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Loa Loa (eye worm) ctsf protein 0.0026 0.0542 0.0934
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0095 0.0085
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0142 0.0133
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0542 0.4445
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Toxoplasma gondii cathepsin B 0.0051 0.1153 0.9235
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0248
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0142 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0542 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0144 0.0831
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Brugia malayi sulfakinin receptor protein 0.0008 0.0095 0.0163
Schistosoma mansoni smad1 5 8 and 0.0008 0.0088 0.0078
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0024 0.0014
Loa Loa (eye worm) cathepsin B 0.0051 0.1153 0.1988
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0144 0.0248
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0142 0.0133
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0142 0.0245
Echinococcus multilocularis cysteine protease 0.0026 0.0542 0.0532
Onchocerca volvulus 0.0008 0.0095 0.143
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0142 0.0133
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Loa Loa (eye worm) cysteine protease 0.0026 0.0542 0.0934
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Echinococcus multilocularis allatostatin A receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0095 0.0085
Schistosoma mansoni opsin-like receptor 0.0008 0.0095 0.0085
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0095 0.0085
Echinococcus multilocularis neuropeptide receptor A26 0.0008 0.0095 0.0085
Brugia malayi hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0008 0.0095 0.0085
Schistosoma mansoni adenoreceptor 0.0008 0.0095 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0542 0.3941
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0141 0.3406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.001 0.0144 0.0831
Onchocerca volvulus Cathepsin L homolog 0.001 0.0144 0.2265
Brugia malayi G-protein coupled receptor 0.0008 0.0095 0.0163
Echinococcus multilocularis cathepsin b 0.0141 0.3406 0.3399
Brugia malayi hypothetical protein 0.0005 0.001 0.0017
Echinococcus multilocularis dnaJ subfamily B 0.0406 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0095 0.0085
Giardia lamblia Cathepsin B precursor 0.0051 0.1153 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0142 0.0245
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0008 0.0095 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0144 0.0831
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0144 0.0248
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0088 0.0151
Brugia malayi MH1 domain containing protein 0.0008 0.0088 0.0151
Brugia malayi hypothetical protein 0.0008 0.0095 0.0163
Onchocerca volvulus 0.0026 0.0542 0.8987
Echinococcus granulosus cathepsin L cysteine proteinase 0.0026 0.0542 0.0532
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0542 0.0532
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0142 0.0245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0095 0.0085
Brugia malayi ecdysone receptor 0.0005 0.001 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0095 0.0085
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0142 0.0133
Schistosoma mansoni opsin-like receptor 0.0008 0.0095 0.0085
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0542 0.8987
Brugia malayi ORL1-like opioid receptor 0.0008 0.0095 0.0163
Giardia lamblia Cathepsin B precursor 0.0051 0.1153 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0051 0.1153 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Brugia malayi hypothetical protein 0.0008 0.0095 0.0163
Brugia malayi hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus sex peptide receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.0144 0.0831
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0144 0.0831
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Loa Loa (eye worm) hypothetical protein 0.0026 0.0542 0.0934
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0051 0.1153 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0142 0.2239
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Loa Loa (eye worm) papain family cysteine protease containing protein 0.001 0.0144 0.0248
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0142 0.0133
Onchocerca volvulus 0.0008 0.0095 0.143
Echinococcus multilocularis serotonin receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.001 0.0144 0.0248
Schistosoma mansoni opsin-like receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) DR-78 0.0005 0.001 0.0017
Onchocerca volvulus 0.001 0.0144 0.2265
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Echinococcus multilocularis G protein coupled receptor 139 0.0008 0.0095 0.0085
Brugia malayi cathepsin F-like cysteine proteinase 0.001 0.0144 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0245
Echinococcus granulosus G protein coupled receptor 139 0.0008 0.0095 0.0085
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0142 0.0133
Brugia malayi hypothetical protein 0.0008 0.0095 0.0163
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0008 0.0095 0.0085
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0542 0.1219
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0095 0.0085
Echinococcus granulosus cysteine protease 0.001 0.0144 0.0134
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Schistosoma mansoni hypothetical protein 0.0406 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0142 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.001 0.0144 0.0831
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0144 0.0134
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0008 0.0095 0.0085
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.001 0.0144 0.0831
Echinococcus granulosus alpha 1A adrenergic receptor 0.0008 0.0095 0.0085
Brugia malayi cathepsin L precursor 0.001 0.0144 0.0248
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0095 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0142 0.0245
Schistosoma mansoni cpg binding protein 0.0028 0.0601 0.0592
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0248
Echinococcus granulosus cathepsin b 0.0141 0.3406 0.3399
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0095 0.0085
Schistosoma mansoni neuropeptide receptor 0.0008 0.0095 0.0085
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0111 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.001 0.0144 0.0831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0245
Brugia malayi ecdysteroid receptor 0.001 0.0142 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.001 0.0144 0.0831
Onchocerca volvulus 0.0026 0.0542 0.8987
Echinococcus granulosus 7TM GPCR rhodopsin 0.0008 0.0095 0.0085
Echinococcus granulosus g protein coupled receptor 0.0008 0.0095 0.0085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0144 0.0134
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0542 0.4445
Brugia malayi nuclear hormone receptor 0.0005 0.001 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Echinococcus granulosus geminin 0.0169 0.4094 0.4088
Echinococcus multilocularis cathepsin L 0.001 0.0144 0.0134
Brugia malayi Melatonin receptor type 1A 0.0008 0.0095 0.0163
Schistosoma mansoni smad1 5 8 and 0.0008 0.0088 0.0078
Schistosoma mansoni myosin xvIII 0.0008 0.0095 0.0085
Brugia malayi CXXC zinc finger family protein 0.0028 0.0601 0.1037
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0095 0.0085
Onchocerca volvulus 0.0026 0.0542 0.8987
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.3406 0.3399
Brugia malayi neuropeptide F receptor 0.0008 0.0095 0.0163
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0142 0.0245
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0142 0.0245
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.001 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0142 0.0245
Echinococcus granulosus 7tm_1 domain containing protein 0.0008 0.0095 0.0085
Brugia malayi MH2 domain containing protein 0.0008 0.0088 0.0151
Schistosoma mansoni hypothetical protein 0.0008 0.0095 0.0085
Brugia malayi Tachykinin-like peptides receptor 99D 0.0008 0.0095 0.0163
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.0042
Echinococcus granulosus cpg binding protein 0.003 0.0642 0.0633
Schistosoma mansoni hypothetical protein 0.0008 0.0095 0.0085
Echinococcus multilocularis somatostatin receptor 0.0008 0.0095 0.0085
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0111 0.0101
Brugia malayi Dopamine receptor protein 2 0.0008 0.0095 0.0163
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Brugia malayi hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus cathepsin L 0.001 0.0144 0.0134
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0095 0.0085
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0095 0.0085
Onchocerca volvulus 0.0026 0.0542 0.8987
Brugia malayi GnHR receptor homolog 0.0008 0.0095 0.0163
Echinococcus granulosus neuropeptide receptor 0.0008 0.0095 0.0085
Echinococcus granulosus peptide allatostatin:somatostatin 0.0008 0.0095 0.0085
Schistosoma mansoni growth hormone secretagogue receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus serotonin receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Loa Loa (eye worm) melatonin receptor type 1A 0.0008 0.0095 0.0163
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.0042
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0008 0.0095 0.0163
Loa Loa (eye worm) Smad1 0.0008 0.0088 0.0151
Echinococcus granulosus cathepsin l cysteine peptidase 0.0026 0.0542 0.0532
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Brugia malayi Nuclear hormone receptor E75 0.0005 0.001 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0095 0.0163
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0095 0.0085
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0024 0.0042
Onchocerca volvulus 0.0008 0.0095 0.143
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.1153 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.001 0.0017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.001 0.0017
Onchocerca volvulus 0.0028 0.0601 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0142 0.0245
Echinococcus granulosus cathepsin l1 0.0026 0.0542 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0088 0.0078
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0142 0.2239
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Brugia malayi hypothetical protein 0.0005 0.0024 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0142 0.0245
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Brugia malayi G-protein coupled receptor 0.0008 0.0095 0.0163
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0142 0.0133
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0008 0.0095 0.143
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0141 0.3406 0.5873
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0008 0.0095 0.0163
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Schistosoma mansoni cathepsin B (C01 family) 0.001 0.0144 0.0134
Echinococcus granulosus fmrfamide receptor 0.0008 0.0095 0.0085
Brugia malayi nuclear receptor NHR-88 0.0005 0.001 0.0017
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0051 0.1153 0.3093
Brugia malayi neuropeptide F receptor 0.0008 0.0095 0.0163
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0008 0.0095 0.0085
Brugia malayi Cathepsin L-like precursor 0.0026 0.0542 0.0934
Schistosoma mansoni thyroid hormone receptor 0.001 0.0142 0.0133
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0601 0.1037
Brugia malayi follicle stimulating hormone receptor 0.0237 0.5799 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0542 0.3941
Echinococcus granulosus tachykinin peptides receptor 99D 0.0008 0.0095 0.0085
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0144 0.0248
Schistosoma mansoni amine GPCR 0.0008 0.0095 0.0085
Onchocerca volvulus 0.0008 0.0095 0.143
Schistosoma mansoni hypothetical protein 0.0169 0.4094 0.4088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0542 0.4445
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.001 0.0144 0.0134
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0542 0.0532
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0542 0.1219
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0088 0.0078
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0142 0.0133
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0542 0.4445
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0142 0.0133
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0109 0.0187
Brugia malayi Smad1 0.0008 0.0088 0.0151
Schistosoma mansoni amine GPCR 0.0008 0.0095 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0542 0.3941
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0008 0.0095 0.0163
Echinococcus granulosus somatostatin receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0245
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.001 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.001 0.0144 0.0831
Schistosoma mansoni neuropeptide receptor 0.0008 0.0095 0.0085
Brugia malayi cathepsin L-like precursor 0.0026 0.0542 0.0934
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0542 0.8987
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0142 0.0133
Brugia malayi Cathepsin L-like precursor 0.0026 0.0542 0.0934
Echinococcus multilocularis neuropeptide s receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.5799 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0144 0.0134
Echinococcus granulosus g-protein coupled receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0542 0.4445
Brugia malayi steroid hormone receptor 0.001 0.0142 0.0245
Schistosoma mansoni biogenic amine receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Schistosoma mansoni hypothetical protein 0.0169 0.4094 0.4088
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0142 0.0133
Echinococcus multilocularis cathepsin b 0.0141 0.3406 0.3399
Brugia malayi G protein-coupled receptor 0.0008 0.0095 0.0163
Echinococcus granulosus neuropeptide s receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Echinococcus multilocularis G-protein coupled receptor, putative 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Brugia malayi Cathepsin L-like precursor 0.0026 0.0542 0.0934
Loa Loa (eye worm) hypothetical protein 0.0026 0.0542 0.0934
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0095 0.0085
Schistosoma mansoni smad1 5 8 and 0.0008 0.0088 0.0078
Brugia malayi nuclear receptor RXR 0.0005 0.001 0.0017
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0026 0.0542 0.0934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Brugia malayi nuclear receptor NHR-88 0.001 0.0142 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0542 1
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0095 0.0085
Brugia malayi hypothetical protein 0.0008 0.0095 0.0163
Onchocerca volvulus 0.0008 0.0095 0.143
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0008 0.0095 0.0085
Onchocerca volvulus 0.0008 0.0095 0.143
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.001 0.0144 0.0831
Echinococcus granulosus cathepsin l1 0.0026 0.0542 0.0532
Echinococcus multilocularis serotonin receptor 0.0008 0.0095 0.0085
Brugia malayi Cathepsin L-like precursor 0.0026 0.0542 0.0934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0144 0.0134
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0008 0.0095 0.0085
Echinococcus multilocularis cysteine protease 0.0026 0.0542 0.0532
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus multilocularis geminin 0.0169 0.4094 0.4088
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.001 0.0144 0.0134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0144 0.0134
Brugia malayi putative neuropeptide receptor 0.0008 0.0095 0.0163
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0248
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0068 0.0058
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0008 0.0095 0.0085
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0095 0.0085
Brugia malayi conserved hypotetical protein 0.0005 0.001 0.0017
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0024 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0142 0.0245
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.2765 0.4768
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0026 0.0542 0.1219
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0142 0.0245
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0142 0.0133
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Schistosoma mansoni cathepsin C 0.001 0.0144 0.0134
Onchocerca volvulus 0.0008 0.0095 0.143
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0095 0.0085
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Onchocerca volvulus 0.0008 0.0095 0.143
Schistosoma mansoni coup transcription factor 0.001 0.0142 0.0133
Schistosoma mansoni cpg binding protein 0.003 0.0642 0.0633
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0142 0.0133
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0542 0.0532
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0095 0.0085
Brugia malayi nuclear hormone receptor 0.001 0.0142 0.0245
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0095 0.0085
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0095 0.0085
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0542 0.1219
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.0144 0.0831
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus multilocularis smad 0.0008 0.0088 0.0078
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0024 0.0042
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.0042
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0144 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0144 0.0831
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0542 0.0532
Echinococcus multilocularis neuropeptide FF receptor 2 0.0008 0.0095 0.0085
Echinococcus granulosus neuropeptide FF receptor 2 0.0008 0.0095 0.0085
Schistosoma mansoni hypothetical protein 0.0008 0.0095 0.0085
Schistosoma mansoni amine GPCR 0.0008 0.0095 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0142 0.0245
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0142 0.0245
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0142 0.0133
Onchocerca volvulus 0.001 0.0142 0.2239
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0142 0.0133
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0248
Onchocerca volvulus 0.0008 0.0095 0.143
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0144 0.0134
Brugia malayi MH1 domain containing protein 0.0008 0.0088 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0095 0.0085
Echinococcus multilocularis Smad4 0.0008 0.0088 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0144 0.0831
Echinococcus granulosus allatostatin A receptor 0.0008 0.0095 0.0085
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0008 0.0095 0.0085
Onchocerca volvulus 0.0026 0.0542 0.8987
Schistosoma mansoni amine GPCR 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0542 0.4445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0245
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0245
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.3406 0.3399
Onchocerca volvulus 0.0008 0.0095 0.143
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0248
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0008 0.0095 0.0085
Brugia malayi cathepsin L-like cysteine proteinase 0.001 0.0144 0.0248
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0068 0.0058
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0142 0.0133
Onchocerca volvulus 0.0008 0.0095 0.143
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Echinococcus granulosus neuropeptide receptor A26 0.0008 0.0095 0.0085
Schistosoma mansoni smad 0.0008 0.0088 0.0078
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0245
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.001 0.0017
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.001 0.0144 0.0134
Brugia malayi Dopamine receptor 0.0008 0.0095 0.0163
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0008 0.0095 0.0163
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0542 0.1219
Brugia malayi nuclear receptor RXR 0.0005 0.0024 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0095 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0542 0.3941
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0008 0.0095 0.0163
Schistosoma mansoni cpg binding protein 0.003 0.0642 0.0633
Brugia malayi fibroinase precursor 0.001 0.0144 0.0248
Schistosoma mansoni alpha-1 adrenergic receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Schistosoma mansoni biogenic amine receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Brugia malayi cahepsin L-like non-peptiedase homolog 0.001 0.0144 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0142 0.0245
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.1153 0.1144
Echinococcus granulosus cathepsin L 0.001 0.0144 0.0134
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0141 0.3406 0.3399
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.001 0.0017
Brugia malayi Cathepsin L-like precursor 0.0026 0.0542 0.0934
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0144 0.0831
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0542 0.3941
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0026 0.0542 1
Brugia malayi Serotonin receptor 0.0008 0.0095 0.0163
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0068 0.0058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0142 0.0245
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.001 0.0017
Brugia malayi AKH receptor 0.0008 0.0095 0.0163
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0008 0.0095 0.0163
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.0042
Schistosoma mansoni neuropeptide receptor 0.0008 0.0095 0.0085
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0095 0.0085
Brugia malayi G protein-coupled receptor F59B2.13 0.0008 0.0095 0.0163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.001 0.0144 0.0831
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0024 0.0014
Brugia malayi Cathepsin L-like precursor 0.0026 0.0542 0.0934
Echinococcus granulosus neuropeptide receptor 0.0008 0.0095 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0542 0.3941
Onchocerca volvulus 0.0008 0.0095 0.143
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0095 0.0163
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0142 0.0133
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0024 0.0014
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0095 0.0085
Brugia malayi Cathepsin L-like precursor 0.0026 0.0542 0.0934
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0542 0.4445
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Brugia malayi hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0142 0.0133
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0144 0.0248
Loa Loa (eye worm) papain family cysteine protease containing protein 0.001 0.0144 0.0248
Brugia malayi hypothetical protein 0.0008 0.0095 0.0163
Schistosoma mansoni thyroid hormone receptor 0.001 0.0142 0.0133
Brugia malayi larval opioid receptor 0.0008 0.0095 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0142 0.0133
Schistosoma mansoni nuclear hormone receptor 0.001 0.0142 0.0133
Brugia malayi Dopamine receptor protein 1 0.0008 0.0095 0.0163
Plasmodium falciparum cysteine proteinase falcipain 3 0.0026 0.0542 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.001 0.0144 0.0248
Plasmodium vivax vivapain-2 0.0026 0.0542 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0095 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0542 0.3941
Toxoplasma gondii cathepsin CPL 0.0026 0.0542 0.364
Onchocerca volvulus 0.0008 0.0095 0.143
Schistosoma mansoni amine GPCR 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0144 0.0831
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0144 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0142 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0542 0.3941
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Echinococcus granulosus smad 0.0008 0.0088 0.0078
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0088 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0095 0.0085
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1397 0.1389
Brugia malayi hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0095 0.0085
Echinococcus granulosus g protein coupled receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Onchocerca volvulus Neuropeptide F receptor homolog 0.0008 0.0095 0.143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0142 0.0133
Brugia malayi RE15519p 0.0008 0.0095 0.0163
Brugia malayi MH2 domain containing protein 0.0115 0.2765 0.4768
Loa Loa (eye worm) hypothetical protein 0.0026 0.0542 0.0934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0144 0.0831
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0088 0.0078
Echinococcus granulosus hypothetical protein 0.0008 0.0095 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0542 0.4445
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0068 0.0058
Onchocerca volvulus 0.0026 0.0542 0.8987
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0142 0.0133
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Onchocerca volvulus Cathepsin F homolog 0.0026 0.0542 0.8987
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0142 0.0133
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus multilocularis orexin receptor type 2 0.0008 0.0095 0.0085
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0008 0.0095 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0542 0.3941
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0542 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.001 0.0144 0.0134
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0542 0.0532
Echinococcus granulosus orexin receptor type 2 0.0008 0.0095 0.0085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0144 0.0134
Echinococcus multilocularis sex peptide receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0542 0.0934
Loa Loa (eye worm) hypothetical protein 0.0005 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus g protein coupled receptor 0.0008 0.0095 0.0085
Brugia malayi MH2 domain containing protein 0.0008 0.0088 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0144 0.0831
Echinococcus multilocularis dro:myosuppressin receptor 0.0008 0.0095 0.0085
Brugia malayi nuclear receptor NHR-67 0.0005 0.001 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Giardia lamblia Cathepsin B precursor 0.0051 0.1153 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0095 0.0085
Echinococcus granulosus cathepsin b 0.0141 0.3406 0.3399
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1236 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0142 0.0133
Brugia malayi Cathepsin L-like precursor 0.0026 0.0542 0.0934
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0026 0.0542 1
Schistosoma mansoni hypothetical protein 0.0008 0.0095 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0142 0.0245
Loa Loa (eye worm) hypothetical protein 0.0026 0.0542 0.0934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0542 0.4445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0142 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0542 0.4445
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Echinococcus granulosus FTZ F1 alpha 0.001 0.0142 0.0133
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0095 0.0085
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0095 0.0085
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0088 0.0078
Onchocerca volvulus 0.0026 0.0542 0.8987
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0542 0.1219
Loa Loa (eye worm) fibroinase 0.0026 0.0542 0.0934
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0095 0.0085
Echinococcus granulosus dro:myosuppressin receptor 0.0008 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Loa Loa (eye worm) hypothetical protein 0.0008 0.0095 0.0163
Onchocerca volvulus 0.0026 0.0542 0.8987
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0095 0.0085
Brugia malayi Cathepsin L-like cysteine proteinase 0.0026 0.0542 0.0934
Echinococcus multilocularis cpg binding protein 0.003 0.0642 0.0633
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0142 0.0133
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0088 0.0078
Onchocerca volvulus 0.0008 0.0095 0.143
Brugia malayi Nuclear hormone receptor E75 0.0005 0.001 0.0017
Schistosoma mansoni cathepsin S (C01 family) 0.001 0.0144 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0542 0.3941
Brugia malayi hypothetical protein 0.0005 0.001 0.0017
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0024 0.0042

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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