Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | CCR4 NOT transcription complex subunit 6 | 0.0008 | 0.0708 | 0.014 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0008 | 0.0708 | 0.1198 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0008 | 0.0708 | 0.1198 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0038 | 0.5911 | 1 |
Echinococcus multilocularis | neutral sphingomyelinase | 0.0008 | 0.0708 | 0.014 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0008 | 0.0708 | 0.1198 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0038 | 0.5911 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0038 | 0.5911 | 1 |
Schistosoma mansoni | cript-related | 0.0008 | 0.0708 | 0.0606 |
Schistosoma mansoni | nocturnin | 0.0008 | 0.0708 | 0.0606 |
Schistosoma mansoni | ap endonuclease | 0.0038 | 0.5911 | 0.5866 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0038 | 0.5911 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.8867 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0038 | 0.5911 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4678 | 0.4619 |
Echinococcus granulosus | traf and tnf receptor associated protein | 0.0008 | 0.0708 | 0.014 |
Onchocerca volvulus | 0.0029 | 0.4393 | 1 | |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 0.5911 | 1 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0008 | 0.0708 | 0.1198 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.0888 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.4393 | 0.7082 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0038 | 0.5911 | 1 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0008 | 0.0708 | 0.1198 |
Schistosoma mansoni | ap endonuclease | 0.0038 | 0.5911 | 0.5866 |
Echinococcus granulosus | inositol polyphosphate 5 phosphatase OCRL 1 | 0.0008 | 0.0708 | 0.014 |
Echinococcus multilocularis | traf and tnf receptor associated protein | 0.0008 | 0.0708 | 0.014 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 0.5911 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.4678 | 0.7663 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4393 | 0.4331 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.0578 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0038 | 0.5911 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0038 | 0.5911 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0708 | 0.0606 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0525 | 0.0888 |
Echinococcus granulosus | CCR4 NOT transcription complex subunit 6 | 0.0008 | 0.0708 | 0.014 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.0888 |
Echinococcus granulosus | neutral sphingomyelinase | 0.0008 | 0.0708 | 0.014 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0038 | 0.5911 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0038 | 0.5911 | 1 |
Echinococcus multilocularis | inositol polyphosphate 5 phosphatase OCRL 1 | 0.0008 | 0.0708 | 0.014 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.0888 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.0888 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.0888 |
Toxoplasma gondii | exonuclease III APE | 0.0038 | 0.5911 | 0.6378 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0008 | 0.0708 | 0.1198 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.0578 |
Schistosoma mansoni | carbon catabolite repressor protein | 0.0008 | 0.0708 | 0.0606 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.0888 |
Echinococcus multilocularis | deoxyribonuclease 1 2 | 0.0008 | 0.0708 | 0.014 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.0888 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.0888 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0008 | 0.0708 | 0.1198 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.0888 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.4678 | 0.7663 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 0.0888 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0939 | 0.0444 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.0888 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 0.0888 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.0888 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0038 | 0.5911 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0038 | 0.5911 | 1 |
Schistosoma mansoni | synaptojanin | 0.0008 | 0.0708 | 0.0606 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.0888 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0038 | 0.5911 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0038 | 0.5911 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.092 | 0.0406 |
Echinococcus granulosus | synaptojanin 1 | 0.0008 | 0.0708 | 0.014 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.0888 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0008 | 0.0708 | 0.014 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0008 | 0.0708 | 0.1198 |
Schistosoma mansoni | neutral sphingomyelinase | 0.0008 | 0.0708 | 0.0606 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4678 | 0.4619 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0038 | 0.5911 | 1 |
Schistosoma mansoni | ocrl type II inositol 5-phosphatase | 0.0008 | 0.0708 | 0.0606 |
Schistosoma mansoni | synaptojanin | 0.0008 | 0.0708 | 0.0606 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0008 | 0.0708 | 0.014 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0038 | 0.5911 | 1 |
Echinococcus multilocularis | synaptojanin 1 | 0.0008 | 0.0708 | 0.014 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0008 | 0.0708 | 0.1198 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.0888 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.0888 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0531 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.4393 | 0.7082 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.7781 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.