Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0564 | 0.0789 | 0.1519 |
Brugia malayi | nuclear hormone receptor | 0.0266 | 0.0353 | 0.0353 |
Brugia malayi | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Onchocerca volvulus | Bile acid receptor homolog | 0.686 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0564 | 0.0789 | 0.0789 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.2228 | 0.3223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Leishmania major | cytochrome p450-like protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | DR-78 | 0.0266 | 0.0353 | 0.0353 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0564 | 0.0789 | 0.1791 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0564 | 0.0789 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0564 | 0.0789 | 0.1519 |
Schistosoma mansoni | nuclear hormone receptor | 0.0564 | 0.0789 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.04 | 0.04 |
Brugia malayi | steroid hormone receptor | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0564 | 0.0789 | 0.0789 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0564 | 0.0789 | 0.0452 |
Brugia malayi | tailless protein | 0.0266 | 0.0353 | 0.0353 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0564 | 0.0789 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Brugia malayi | nuclear receptor NHR-67 | 0.0266 | 0.0353 | 0.0353 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0564 | 0.0789 | 0.1519 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0564 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.04 | 0.04 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0564 | 0.0789 | 0.1791 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0298 | 0.04 | 0.0163 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0564 | 0.0789 | 0.0789 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0564 | 0.0789 | 0.1519 |
Brugia malayi | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0564 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0564 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0266 | 0.0353 | 0.0353 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0564 | 0.0789 | 0.1519 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0266 | 0.0353 | 0.0353 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0564 | 0.0789 | 0.0789 |
Trypanosoma brucei | cytochrome P450, putative | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0564 | 0.0789 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.686 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0564 | 0.0789 | 0.0789 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0298 | 0.04 | 0.0192 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0564 | 0.0789 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0564 | 0.0789 | 0.0789 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0564 | 0.0789 | 0.1519 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0564 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | nuclear receptor NHR-88 | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0266 | 0.0353 | 0.0353 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0266 | 0.0353 | 0.0353 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0564 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0298 | 0.04 | 0.04 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0298 | 0.04 | 0.0163 |
Schistosoma mansoni | thyroid hormone receptor | 0.0564 | 0.0789 | 0.1519 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.2228 | 0.3223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.04 | 0.04 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0564 | 0.0789 | 0.0789 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0564 | 0.0789 | 0.1519 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0266 | 0.0353 | 0.0353 |
Brugia malayi | hypothetical protein | 0.0298 | 0.04 | 0.04 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0564 | 0.0789 | 0.1519 |
Brugia malayi | hypothetical protein | 0.0298 | 0.04 | 0.04 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0298 | 0.04 | 0.04 |
Loa Loa (eye worm) | hypothetical protein | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | nuclear receptor RXR | 0.0298 | 0.04 | 0.04 |
Schistosoma mansoni | coup transcription factor | 0.0564 | 0.0789 | 0.1519 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0564 | 0.0789 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0564 | 0.0789 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | conserved hypotetical protein | 0.0266 | 0.0353 | 0.0353 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0564 | 0.0789 | 0.0452 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0564 | 0.0789 | 0.1791 |
Onchocerca volvulus | 0.0564 | 0.0789 | 0.0452 | |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0564 | 0.0789 | 0.1791 |
Brugia malayi | nuclear hormone receptor | 0.0564 | 0.0789 | 0.0789 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0564 | 0.0789 | 0.1519 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0564 | 0.0789 | 0.1519 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0564 | 0.0789 | 0.1791 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0564 | 0.0789 | 0.0789 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.193 | 0.2787 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0298 | 0.04 | 0.04 |
Brugia malayi | nuclear receptor NHR-88 | 0.0564 | 0.0789 | 0.0789 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0564 | 0.0789 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.04 | 0.04 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0564 | 0.0789 | 0.1791 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0564 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0266 | 0.0353 | 0.0353 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0298 | 0.04 | 0.0163 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0564 | 0.0789 | 0.0789 |
Schistosoma mansoni | thyroid hormone receptor | 0.0564 | 0.0789 | 0.1519 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | ecdysone receptor | 0.0266 | 0.0353 | 0.0353 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | nuclear receptor RXR | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0564 | 0.0789 | 0.1791 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0564 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.04 | 0.04 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0564 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0564 | 0.0789 | 0.0789 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0564 | 0.0789 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0564 | 0.0789 | 0.0789 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0266 | 0.0353 | 0.0353 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.