Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.6347 | 0.6347 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.4281 | 0.4281 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4281 | 0.4281 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Giardia lamblia | Kinase, PLK | 0.0114 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4281 | 0.4281 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 1 | 0.5 |
Schistosoma mansoni | kinase | 0.0058 | 0.4546 | 0.4546 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6347 | 0.6347 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 1 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.6347 | 0.6347 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.4281 | 0.4281 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6347 | 0.6347 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.6347 | 0.6347 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.4281 | 0.4281 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.6347 | 0.6347 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6347 | 0.6347 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.6347 | 0.6347 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4281 | 0.4281 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.4281 | 0.4281 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6347 | 0.6347 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.4281 | 0.4281 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0011 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.6347 | 0.6347 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.6347 | 0.6347 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6347 | 0.6347 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.4281 | 0.4281 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.6347 | 0.6347 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.