TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 329.314 | Formula: C16H18F3NO3
H donors: 1 H acceptors: 2 LogP: 1.95 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCCN1C1c2cc(ccc2OC([C@H]1O)(C)C)C(F)(F)F
InChi: 1S/C16H18F3NO3/c1-15(2)14(22)13(20-7-3-4-12(20)21)10-8-9(16(17,18)19)5-6-11(10)23-15/h5-6,8,13-14,22H,3-4,7H2,1-2H3/t13?,14-/m0/s1
InChiKey: CPMUAMNLYJDMRC-KZUDCZAMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	neuropeptide receptor	0.0177	0.1657	0.1994
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0177	0.1657	0.2013
Echinococcus granulosus	acetylcholinesterase	0.0808	0.8231	0.8227
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus multilocularis	somatostatin receptor	0.0177	0.1657	0.164
Echinococcus granulosus	g protein coupled receptor	0.0177	0.1657	0.164
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0205	0.016
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0177	0.1657	0.2013
Brugia malayi	Serotonin receptor	0.0177	0.1657	0.1941
Loa Loa (eye worm)	acetylcholinesterase 1	0.0808	0.8231	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	neuropeptide receptor	0.0177	0.1657	0.1994
Echinococcus granulosus	tm gpcr rhodopsin	0.0177	0.1657	0.164
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0177	0.1657	0.1994
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0096	0.0821	0.0916
Echinococcus multilocularis	carboxylesterase 5A	0.0808	0.8231	0.8227
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0177	0.1657	0.1994
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0256
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0821	0.0803
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0137	0.1241	0.1224
Echinococcus multilocularis	g-protein coupled receptor	0.0177	0.1657	0.164
Onchocerca volvulus		0.0177	0.1657	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0177	0.1657	0.164
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0821	0.0976
Echinococcus multilocularis	g protein coupled receptor	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Brugia malayi	hypothetical protein	0.0177	0.1657	0.1941
Echinococcus granulosus	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1241	0.1508
Leishmania major	hypothetical protein, conserved	0.0076	0.0608	0.5
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0177	0.1657	0.164
Onchocerca volvulus		0.0177	0.1657	1
Schistosoma mansoni	biogenic amine receptor	0.0177	0.1657	0.1994
Echinococcus granulosus	neuropeptide receptor	0.0177	0.1657	0.164
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0608	0.4751
Onchocerca volvulus		0.0137	0.1241	0.6038
Loa Loa (eye worm)	TYRA-2 protein	0.0177	0.1657	0.2013
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Onchocerca volvulus		0.0177	0.1657	1
Echinococcus granulosus	neuroligin	0.0137	0.1241	0.1224
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0177	0.1657	0.164
Echinococcus granulosus	G protein coupled receptor 139	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1241	0.1508
Echinococcus granulosus	orexin receptor type 2	0.0177	0.1657	0.164
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0177	0.1657	0.164
Brugia malayi	GnHR receptor homolog	0.0177	0.1657	0.1941
Brugia malayi	Dopamine receptor	0.0177	0.1657	0.1941
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0137	0.1241	0.1224
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0205	0.0249
Schistosoma mansoni	hypothetical protein	0.0177	0.1657	0.1994
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0177	0.1657	0.1994
Schistosoma mansoni	biogenic amine receptor	0.0177	0.1657	0.1994
Loa Loa (eye worm)	melatonin receptor type 1A	0.0177	0.1657	0.2013
Plasmodium vivax	hypothetical protein, conserved	0.0076	0.0608	0.5
Brugia malayi	G protein-coupled receptor	0.0177	0.1657	0.1941
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0177	0.1657	0.1994
Echinococcus multilocularis	fmrfamide receptor	0.0177	0.1657	0.164
Loa Loa (eye worm)	carboxylesterase	0.0808	0.8231	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0186	0.0167
Echinococcus multilocularis	sex peptide receptor	0.0177	0.1657	0.164
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0177	0.1657	0.1941
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0177	0.1657	0.1994
Entamoeba histolytica	hypothetical protein	0.0039	0.0226	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0177	0.1657	0.1941
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.1167	0.1418
Schistosoma mansoni	myosin xvIII	0.0177	0.1657	0.1994
Brugia malayi	putative neuropeptide receptor	0.0177	0.1657	0.1941
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Brugia malayi	hypothetical protein	0.0177	0.1657	0.1941
Onchocerca volvulus		0.0177	0.1657	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0177	0.1657	0.1994
Loa Loa (eye worm)	carboxylesterase	0.0137	0.1241	0.1508
Onchocerca volvulus		0.0177	0.1657	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0177	0.1657	0.164
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0137	0.1241	0.1488
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0177	0.1657	0.164
Toxoplasma gondii	ABC1 family protein	0.0076	0.0608	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0226	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0226	0.0207
Brugia malayi	Carboxylesterase family protein	0.0137	0.1241	0.1431
Schistosoma mansoni	neuropeptide receptor	0.0177	0.1657	0.1994
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Onchocerca volvulus		0.0177	0.1657	1
Onchocerca volvulus		0.0177	0.1657	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Loa Loa (eye worm)	neuropeptide F receptor	0.0177	0.1657	0.2013
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0137	0.1241	0.1491
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0083	0.0679	0.5343
Schistosoma mansoni	histamine h1 receptor	0.0177	0.1657	0.1994
Schistosoma mansoni	biogenic amine receptor	0.0177	0.1657	0.1994
Loa Loa (eye worm)	G-protein coupled receptor	0.0177	0.1657	0.2013
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1241	0.1508
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0177	0.1657	0.1994
Onchocerca volvulus		0.0177	0.1657	1
Brugia malayi	MH2 domain containing protein	0.0129	0.1167	0.1341
Brugia malayi	hypothetical protein	0.0177	0.1657	0.1941
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Trichomonas vaginalis	spcc417.12 protein, putative	0.0137	0.1241	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0096	0.0821	0.0997
Echinococcus granulosus	neuropeptides capa receptor	0.0177	0.1657	0.164
Brugia malayi	hypothetical protein	0.0177	0.1657	0.1941
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Schistosoma mansoni	opsin-like receptor	0.0177	0.1657	0.1994
Onchocerca volvulus		0.0177	0.1657	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0978	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.003	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0608	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus granulosus	acetylcholinesterase	0.0808	0.8231	0.8227
Entamoeba histolytica	hypothetical protein	0.0039	0.0226	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0137	0.1241	0.1488
Echinococcus granulosus	somatostatin receptor	0.0177	0.1657	0.164
Echinococcus granulosus	g protein coupled receptor	0.0177	0.1657	0.164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Echinococcus granulosus	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Schistosoma mansoni	acetylcholinesterase	0.0137	0.1241	0.1488
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0177	0.1657	0.1994
Schistosoma mansoni	amine GPCR	0.0177	0.1657	0.1994
Echinococcus multilocularis	neuropeptides capa receptor	0.0177	0.1657	0.164
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0484	0.4854	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0177	0.1657	0.2013
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Brugia malayi	Bromodomain containing protein	0.0073	0.0584	0.0626
Echinococcus granulosus	7tm_1 domain containing protein	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0069	0.054	0.0657
Echinococcus multilocularis	orexin receptor type 2	0.0177	0.1657	0.164
Onchocerca volvulus		0.0137	0.1241	0.6038
Schistosoma mansoni	hypothetical protein	0.0039	0.0226	0.0252
Schistosoma mansoni	amine GPCR	0.0177	0.1657	0.1994
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0177	0.1657	0.1994
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0137	0.1241	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0608	0.0739
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0177	0.1657	0.1994
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0177	0.1657	0.1941
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.0608	0.4751
Onchocerca volvulus		0.0177	0.1657	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	growth hormone secretagogue receptor	0.0177	0.1657	0.1994
Brugia malayi	hypothetical protein	0.0177	0.1657	0.1941
Echinococcus granulosus	neuropeptides capa receptor	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0608	0.0739
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0186	0.0167
Echinococcus multilocularis	neuropeptide receptor	0.0177	0.1657	0.164
Echinococcus granulosus	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Schistosoma mansoni	hypothetical protein	0.0177	0.1657	0.1994
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0177	0.1657	0.1994
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus multilocularis	acetylcholinesterase	0.0808	0.8231	0.8227
Echinococcus granulosus	dro:myosuppressin receptor	0.0177	0.1657	0.164
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0226	0.0207
Schistosoma mansoni	neuropeptide f receptor 76f	0.0177	0.1657	0.1994
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	bromodomain containing protein	0.0062	0.0465	0.0542
Echinococcus granulosus	hypothetical protein	0.0177	0.1657	0.164
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0177	0.1657	0.1994
Echinococcus granulosus	neuropeptide Y receptor	0.0177	0.1657	0.164
Brugia malayi	Melatonin receptor type 1A	0.0177	0.1657	0.1941
Echinococcus multilocularis	acetylcholinesterase	0.0808	0.8231	0.8227
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0177	0.1657	0.164
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.0428	0.041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0137	0.1241	0.1491
Schistosoma mansoni	hypothetical protein	0.002	0.003	0.0013
Onchocerca volvulus		0.0137	0.1241	0.6038
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0821	0.0976
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0608	0.0739
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0177	0.1657	0.164
Brugia malayi	hypothetical protein	0.0039	0.0226	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Brugia malayi	sulfakinin receptor protein	0.0177	0.1657	0.1941
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0383	0.0465
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0177	0.1657	0.164
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0177	0.1657	0.2013
Brugia malayi	AKH receptor	0.0177	0.1657	0.1941
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Echinococcus granulosus	tm gpcr rhodopsin	0.0177	0.1657	0.164
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0177	0.1657	0.1994
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0254	0.0309
Brugia malayi	neuropeptide F receptor	0.0177	0.1657	0.1941
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1241	0.1508
Echinococcus granulosus	g protein coupled receptor	0.0177	0.1657	0.164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Brugia malayi	hypothetical protein	0.0137	0.1241	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0177	0.1657	0.1994
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Brugia malayi	hypothetical protein	0.0177	0.1657	0.1941
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Mycobacterium leprae	conserved hypothetical protein	0.0076	0.0608	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0177	0.1657	0.1994
Brugia malayi	larval opioid receptor	0.0177	0.1657	0.1941
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0177	0.1657	0.164
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0083	0.0679	0.5343
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0177	0.1657	0.164
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0177	0.1657	0.164
Onchocerca volvulus		0.0177	0.1657	1
Brugia malayi	hypothetical protein	0.0177	0.1657	0.1941
Giardia lamblia	NADPH oxidoreductase, putative	0.0083	0.0679	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0608	0.4751
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	hypothetical protein	0.0177	0.1657	0.1994
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.0608	0.4751
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0177	0.1657	1
Echinococcus granulosus	serotonin receptor	0.0177	0.1657	0.164
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.005	0.003
Schistosoma mansoni	neuropeptide F-like receptor	0.0177	0.1657	0.1994
Echinococcus granulosus	neuropeptide FF receptor 2	0.0177	0.1657	0.164
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Echinococcus granulosus	beta LACTamase domain containing family member	0.0076	0.0608	0.059
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1241	0.1508
Brugia malayi	Dopamine receptor protein 1	0.0177	0.1657	0.1941
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0177	0.1657	0.1941
Brugia malayi	hypothetical protein	0.0177	0.1657	0.1941
Brugia malayi	follicle stimulating hormone receptor	0.0177	0.1657	0.1941
Loa Loa (eye worm)	beta-lactamase	0.0076	0.0608	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	opsin-like receptor	0.0177	0.1657	0.1994
Trichomonas vaginalis	esterase, putative	0.0076	0.0608	0.4751
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0177	0.1657	0.1994
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0137	0.1241	0.1491
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.0608	0.5
Entamoeba histolytica	hypothetical protein	0.0039	0.0226	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0177	0.1657	0.1994
Loa Loa (eye worm)	hypothetical protein	0.0808	0.8231	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	amine GPCR	0.0177	0.1657	0.1994
Echinococcus granulosus	carboxylesterase 5A	0.0808	0.8231	0.8227
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0177	0.1657	0.1994
Echinococcus multilocularis	allatostatin A receptor	0.0177	0.1657	0.164
Echinococcus multilocularis	neuropeptide s receptor	0.0177	0.1657	0.164
Echinococcus granulosus	neuropeptide Y receptor	0.0177	0.1657	0.164
Brugia malayi	hypothetical protein	0.0177	0.1657	0.1941
Onchocerca volvulus		0.0137	0.1241	0.6038
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	amine GPCR	0.0177	0.1657	0.1994
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1241	0.1508
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.005	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus multilocularis	dro:myosuppressin receptor	0.0177	0.1657	0.164
Echinococcus granulosus	g-protein coupled receptor	0.0177	0.1657	0.164
Loa Loa (eye worm)	carboxylesterase	0.0137	0.1241	0.1508
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus multilocularis	neuropeptide receptor	0.0177	0.1657	0.164
Echinococcus granulosus	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0608	0.0739
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Echinococcus granulosus	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1241	0.1508
Giardia lamblia	NADPH oxidoreductase, putative	0.0083	0.0679	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.1167	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0177	0.1657	0.164
Echinococcus multilocularis	neuroligin	0.0137	0.1241	0.1224
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.0608	0.4751
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0177	0.1657	0.1994
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0177	0.1657	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0177	0.1657	0.164
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0821	0.0976
Brugia malayi	beta-lactamase family protein	0.0076	0.0608	0.0655
Echinococcus granulosus	sex peptide receptor	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0383	0.0465
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0177	0.1657	0.1994
Echinococcus granulosus	biogenic amine 5HT receptor	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0177	0.1657	0.2013
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.0428	0.041
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0177	0.1657	0.164
Brugia malayi	G-protein coupled receptor	0.0177	0.1657	0.1941
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0821	0.0803
Echinococcus multilocularis	neuropeptide Y receptor	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Brugia malayi	Dopamine receptor protein 2	0.0177	0.1657	0.1941
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0821	0.0803
Echinococcus granulosus	fmrfamide receptor	0.0177	0.1657	0.164
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Onchocerca volvulus		0.0177	0.1657	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0226	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0177	0.1657	0.164
Brugia malayi	G-protein coupled receptor	0.0177	0.1657	0.1941
Onchocerca volvulus		0.0177	0.1657	1
Brugia malayi	hypothetical protein	0.0177	0.1657	0.1941
Brugia malayi	beta-lactamase family protein	0.0076	0.0608	0.0655
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.0608	0.5
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0177	0.1657	0.164
Brugia malayi	Carboxylesterase family protein	0.0137	0.1241	0.1431
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.0608	0.0717
Mycobacterium leprae	Probable lipase LipE	0.0076	0.0608	0.5
Brugia malayi	Bromodomain containing protein	0.0037	0.021	0.0167
Schistosoma mansoni	neuropeptide receptor	0.0177	0.1657	0.1994
Echinococcus multilocularis	neuropeptide Y receptor	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0808	0.8231	1
Brugia malayi	Serotonin receptor	0.0177	0.1657	0.1941
Echinococcus granulosus	biogenic amine 5HT receptor	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0177	0.1657	0.164
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0465	0.3563
Schistosoma mansoni	adenoreceptor	0.0177	0.1657	0.1994
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0177	0.1657	0.1994
Echinococcus multilocularis	fmrfamide receptor	0.0177	0.1657	0.164
Echinococcus granulosus	para nitrobenzyl esterase	0.0137	0.1241	0.1224
Brugia malayi	beta-lactamase	0.0076	0.0608	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus granulosus	7TM GPCR rhodopsin	0.0177	0.1657	0.164
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0076	0.0608	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0076	0.0608	0.059
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0177	0.1657	0.1941
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	hypothetical protein	0.0037	0.0205	0.0225
Giardia lamblia	NADPH oxidoreductase, putative	0.0083	0.0679	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0383	0.0379
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0177	0.1657	0.1994
Onchocerca volvulus		0.0137	0.1241	0.6038
Echinococcus multilocularis	g protein coupled receptor	0.0177	0.1657	0.164
Brugia malayi	G protein-coupled receptor F59B2.13	0.0177	0.1657	0.1941
Echinococcus granulosus	BC026374 protein S09 family	0.0137	0.1241	0.1224
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0177	0.1657	0.1941
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.005	0.003
Brugia malayi	Carboxylesterase family protein	0.0808	0.8231	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0177	0.1657	0.1994
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0137	0.1241	0.1488
Onchocerca volvulus		0.0177	0.1657	1
Onchocerca volvulus		0.0177	0.1657	1
Brugia malayi	Carboxylesterase family protein	0.0137	0.1241	0.1431
Schistosoma mansoni	BC026374 protein (S09 family)	0.0137	0.1241	0.1488
Loa Loa (eye worm)	neuropeptide F receptor	0.0177	0.1657	0.2013
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Echinococcus granulosus	neuropeptide s receptor	0.0177	0.1657	0.164
Brugia malayi	ORL1-like opioid receptor	0.0177	0.1657	0.1941
Loa Loa (eye worm)	hypothetical protein	0.004	0.0235	0.0286
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0177	0.1657	0.164
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0177	0.1657	0.1994
Echinococcus granulosus	neuropeptide receptor A26	0.0177	0.1657	0.164
Loa Loa (eye worm)	G-protein coupled receptor	0.0177	0.1657	0.2013
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.0608	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0608	0.0739
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0808	0.8231	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Brugia malayi	RE15519p	0.0177	0.1657	0.1941
Schistosoma mansoni	gliotactin	0.0137	0.1241	0.1488
Schistosoma mansoni	neuropeptide F-like receptor	0.0177	0.1657	0.1994
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0821	0.0803
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0177	0.1657	0.164
Brugia malayi	Carboxylesterase family protein	0.0808	0.8231	1
Trypanosoma brucei	hypothetical protein, conserved	0.0076	0.0608	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0177	0.1657	0.164
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0177	0.1657	0.164
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0083	0.0679	0.5343
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0177	0.1657	0.164
Echinococcus multilocularis	para nitrobenzyl esterase	0.0137	0.1241	0.1224
Schistosoma mansoni	amine GPCR	0.0177	0.1657	0.1994
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0137	0.1241	1
Schistosoma mansoni	opsin-like receptor	0.0177	0.1657	0.1994
Brugia malayi	Carboxylesterase family protein	0.0137	0.1241	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0679	0.5343
Echinococcus multilocularis	serotonin receptor	0.0177	0.1657	0.164
Brugia malayi	putative neuropeptide receptor NPR1	0.0177	0.1657	0.1941
Onchocerca volvulus		0.0177	0.1657	1
Schistosoma mansoni	hypothetical protein	0.0177	0.1657	0.1994
Echinococcus multilocularis	g protein coupled receptor	0.0177	0.1657	0.164
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0383	0.0379
Mycobacterium ulcerans	carboxylesterase, LipT	0.0137	0.1241	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0177	0.1657	0.164
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0076	0.0608	0.0655
Onchocerca volvulus		0.0177	0.1657	1
Brugia malayi	neuropeptide F receptor	0.0177	0.1657	0.1941
Echinococcus multilocularis	serotonin receptor	0.0177	0.1657	0.164
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0137	0.1241	0.1224
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1657	0.2013
Echinococcus granulosus	neuropeptide receptor	0.0177	0.1657	0.164
Echinococcus granulosus	allatostatin A receptor	0.0177	0.1657	0.164
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0177	0.1657	0.1994

Activities

Activity type	Activity value	Assay description	Source	Reference
Max fall in blood pressure (functional)	= 17 %	The maximum fall in systolic blood pressure was determined at a dose of 0.1 mg/kg after oral administration in rats	ChEMBL.	2231601
Max fall in blood pressure (functional)	= 26 %	The maximum fall in systolic blood pressure was determined at a dose of 0.3 mg/kg after oral administration in rats	ChEMBL.	2231601

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL318148

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 170658