Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.5828 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.5828 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.5828 | 0.4186 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3188 | 0.5469 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2825 | 0.2825 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1523 | 0.2612 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1523 | 0.2612 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1523 | 0.2612 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.5828 | 0.4186 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2825 | 0.2825 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.5828 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.5828 | 0.5 |
Schistosoma mansoni | kinase | 0.0058 | 0.1344 | 0.1344 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2825 | 0.4847 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.5828 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.5828 | 0.5828 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2825 | 0.4847 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2825 | 0.2825 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2825 | 0.4847 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.5828 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2825 | 0.4847 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.5828 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1523 | 0.2612 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Echinococcus multilocularis | geminin | 0.0166 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2825 | 0.4847 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2825 | 0.2825 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.5828 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2825 | 0.2825 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2825 | 0.4847 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.5828 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.6213 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.