Detailed information for compound 1706845

Basic information

Technical information
  • TDR Targets ID: 1706845
  • Name: N-(2-morpholin-4-ylphenyl)naphthalene-1-carbo xamide
  • MW: 332.396 | Formula: C21H20N2O2
  • H donors: 1 H acceptors: 1 LogP: 3.76 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc2c1cccc2)Nc1ccccc1N1CCOCC1
  • InChi: 1S/C21H20N2O2/c24-21(18-9-5-7-16-6-1-2-8-17(16)18)22-19-10-3-4-11-20(19)23-12-14-25-15-13-23/h1-11H,12-15H2,(H,22,24)
  • InChiKey: FKCMULQEBYCNDZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-morpholinophenyl)naphthalene-1-carboxamide
  • N-(2-morpholinophenyl)-1-naphthalenecarboxamide
  • N-(2-morpholinophenyl)-1-naphthamide
  • ZINC00792158
  • T5414651
  • BAS 05231801
  • Naphthalene-1-carboxylic acid (2-morpholin-4-yl-phenyl)-amide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.1668 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 1 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0408 0.5
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0408 0.139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.63 0.63
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.1668 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0408
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.1668 1
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Echinococcus granulosus tar DNA binding protein 0.0076 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.1668 0.5
Mycobacterium ulcerans hypothetical protein 0.0029 0.1668 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.63 0.63
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.1668 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.7163 0.7163
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.7163 0.7163
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.1668 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.1668 0.5
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0408 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0408
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.1668 0.5
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.1668 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.63 0.63
Loa Loa (eye worm) hypothetical protein 0.0029 0.1668 0.1668
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.1668 0.5
Loa Loa (eye worm) RNA binding protein 0.0076 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.1668 1
Onchocerca volvulus 0.0029 0.1668 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.1668 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.3848 0.3848
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.63 0.63
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.63 0.63
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.63 0.63
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0408 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.1668 0.1668
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.1668 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1668 0.1668
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.7163 0.7163
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.1668 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.7163 0.7163
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0408
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Brugia malayi TAR-binding protein 0.0076 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.1668 1
Loa Loa (eye worm) TAR-binding protein 0.0076 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.1668 0.1668
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.1668 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.1668 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0408
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.63 0.63
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.63 0.63
Loa Loa (eye worm) hypothetical protein 0.0021 0.0408 0.0408
Brugia malayi AMP-binding enzyme family protein 0.0029 0.1668 0.1668
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.63 0.63
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.1668 0.1668
Schistosoma mansoni hypothetical protein 0.0041 0.3848 0.3848
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.3848 0.3848
Echinococcus multilocularis tar DNA binding protein 0.0076 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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