Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.0953 | 0.0249 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0033 | 0.0953 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1326 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.5051 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0953 | 0.1887 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.0953 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.5051 | 0.4666 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0953 | 0.0463 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.5051 | 0.4666 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1326 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.5051 | 0.4666 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 1 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0033 | 0.0953 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0953 | 0.0533 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1326 | 0.5 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.0953 | 0.0249 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0033 | 0.0953 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1326 | 0.065 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.0953 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0953 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0953 | 0.0249 |
Mycobacterium ulcerans | pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.5051 | 0.4666 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0953 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1326 | 0.2624 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0953 | 0.0463 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1326 | 0.1393 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5706 | 0.5371 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1326 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0953 | 0.1887 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0953 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5051 | 0.8686 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.5706 | 0.5371 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5051 | 0.8686 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.5706 | 1 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0953 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5051 | 0.8686 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0953 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0033 | 0.0953 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0722 | 0.143 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0953 | 0.0249 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.5051 | 0.4666 |
Brugia malayi | RNA binding protein | 0.0062 | 0.5051 | 0.4666 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1326 | 0.121 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5051 | 0.8686 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5051 | 0.8686 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1326 | 0.121 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.5051 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0953 | 0.0533 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0953 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0722 | 0.143 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0953 | 0.0249 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0953 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0953 | 0.0249 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0722 | 0.143 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.