Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.1447 | 0.948 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.044 | 0.2143 | 0.226 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0924 | 0.567 | 0.5981 |
Brugia malayi | dihydrofolate reductase family protein | 0.1447 | 0.948 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1447 | 0.948 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0924 | 0.567 | 0.5981 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1519 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.1447 | 0.948 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1519 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0924 | 0.567 | 0.5981 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0297 | 0.1108 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.1447 | 0.948 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1519 | 1 | 0.5 |
Onchocerca volvulus | 0.0924 | 0.567 | 0.5 | |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0297 | 0.1108 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1447 | 0.948 | 1 |
Brugia malayi | thymidylate synthase | 0.0924 | 0.567 | 0.4807 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0297 | 0.1108 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1447 | 0.948 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0297 | 0.1108 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.044 | 0.2143 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1519 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1447 | 0.948 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1519 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1447 | 0.948 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1447 | 0.948 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.