Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hepatocyte nuclear factor 4, alpha | Starlite/ChEMBL | No references |
Homo sapiens | perilipin 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Hepatocyte nuclear factor 4-beta, putative | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma japonicum | Transcription factor HNF-4 homolog, putative | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.0265 | 0.1446 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.3154 | 0.3154 |
Echinococcus granulosus | tumor protein p63 | 0.0327 | 0.4502 | 0.4353 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0667 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.0265 | 0.1446 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0145 | 0.156 | 0.156 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0161 | 0.1831 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0265 | 0.0265 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0243 | 0.3154 | 0.2968 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0265 | 0.0265 |
Echinococcus multilocularis | tumor protein p63 | 0.0327 | 0.4502 | 0.4353 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0243 | 0.3154 | 0.2968 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0275 | 0.3666 | 0.3494 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0667 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0161 | 0.1831 | 0.1609 |
Schistosoma mansoni | thyroid hormone receptor | 0.0275 | 0.3666 | 0.3666 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0265 | 0.0265 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0265 | 0.0265 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0161 | 0.1831 | 0.1609 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0161 | 0.1831 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0265 | 0.0265 |
Schistosoma mansoni | thyroid hormone receptor | 0.0275 | 0.3666 | 0.3666 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.0265 | 0.1446 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 2.223 uM | PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 2.558 uM | PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.