Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0032 | 0.3537 | 0.5 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3268 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3268 | 0.3268 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0375 | 0.0375 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.3537 | 0.6116 |
Schistosoma mansoni | lamin | 0.0032 | 0.3537 | 0.6116 |
Schistosoma mansoni | lamin | 0.0032 | 0.3537 | 0.6116 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.3537 | 0.3537 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3268 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0375 | 0.0375 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.3537 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3268 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3268 | 0.5 |
Echinococcus multilocularis | lamin | 0.0032 | 0.3537 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.3268 | 0.5 |
Brugia malayi | hypothetical protein | 0.002 | 0.0664 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3397 | 0.3397 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.3537 | 0.3537 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.5545 | 0.5545 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3537 | 0.3537 |
Echinococcus granulosus | lamin | 0.0032 | 0.3537 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.5545 | 0.5545 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0375 | 0.0375 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.5545 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.3537 | 1 |
Echinococcus multilocularis | musashi | 0.0032 | 0.3537 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.3537 | 0.3537 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.3268 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.3268 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.3537 | 0.3537 |
Onchocerca volvulus | 0.0032 | 0.3537 | 0.5 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.3268 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.3537 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.3268 | 0.3268 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.