TDR Targets

Basic information

Technical information

TDR Targets ID: 1707563
Name: 2-chloro-5-(cyclohexyl-methylsulfamoyl)-N-(2- methoxyethyl)benzamide
MW: 388.909 | Formula: C17H25ClN2O4S
H donors: 1 H acceptors: 3 LogP: 2.64 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COCCNC(=O)c1cc(ccc1Cl)S(=O)(=O)N(C1CCCCC1)C
InChi: 1S/C17H25ClN2O4S/c1-20(13-6-4-3-5-7-13)25(22,23)14-8-9-16(18)15(12-14)17(21)19-10-11-24-2/h8-9,12-13H,3-7,10-11H2,1-2H3,(H,19,21)
InChiKey: QNBXSOFYTMPWGU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-chloro-5-(cyclohexyl-methyl-sulfamoyl)-N-(2-methoxyethyl)benzamide
ZINC03414406
T5336470

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0241	0.0379	0.1007
Echinococcus multilocularis	nuclear receptor nhr 48	0.0241	0.0379	0.1147
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0026	0.0015	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0064	0.0064
Echinococcus multilocularis	ecdysone induced protein 78C	0.0511	0.0837	0.2532
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0241	0.0379	0.1007
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0284	0.0284
Schistosoma mansoni	coup transcription factor	0.0511	0.0837	0.2224
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.0034	0.0034
Brugia malayi	Steroid receptor seven-up type 2	0.0511	0.0837	0.0837
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0026	0.0015	0.0039
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0026	0.0015	0.0039
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.0015
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0511	0.0837	0.2224
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Brugia malayi	nuclear receptor NHR-67	0.0241	0.0379	0.0379
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0241	0.0379	0.1007
Brugia malayi	ecdysone receptor	0.0241	0.0379	0.0379
Plasmodium falciparum	transporter, putative	0.0026	0.0015	0.5
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0026	0.0015	0.0045
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0241	0.0379	0.1147
Onchocerca volvulus	Bile acid receptor homolog	0.5914	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0241	0.0379	0.1007
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0026	0.0015	0.0039
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0511	0.0837	0.0837
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0026	0.0015	0.0015
Echinococcus granulosus	sodium and chloride dependent glycine	0.0026	0.0015	0.0039
Echinococcus granulosus	FTZ F1 alpha	0.0511	0.0837	0.2224
Loa Loa (eye worm)	hypothetical protein	0.027	0.0428	0.0428
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0511	0.0837	0.0837
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0026	0.0015	0.5
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0026	0.0015	0.0015
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Schistosoma mansoni	survival motor neuron protein	0.0054	0.0061	0.0163
Schistosoma mansoni	RAR-like nuclear receptor	0.0511	0.0837	0.2224
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0064	0.0064
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0511	0.0837	0.2224
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0241	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.0015
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.0034	0.0091
Loa Loa (eye worm)	nuclear hormone receptor	0.0241	0.0379	0.0379
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0155	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Echinococcus granulosus	sodium and chloride dependent glycine	0.0026	0.0015	0.0039
Brugia malayi	conserved hypotetical protein	0.0241	0.0379	0.0379
Schistosoma mansoni	nuclear receptor	0.0241	0.0379	0.1007
Schistosoma mansoni	nuclear receptor	0.0241	0.0379	0.1007
Loa Loa (eye worm)	hypothetical protein	0.0511	0.0837	0.0837
Plasmodium vivax	amine transporter, putative	0.0026	0.0015	0.5
Onchocerca volvulus	Protein ultraspiracle homolog	0.0511	0.0837	0.0824
Brugia malayi	nuclear receptor NHR-88	0.0511	0.0837	0.0837
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0511	0.0837	0.2224
Brugia malayi	nuclear hormone receptor family member odr-7	0.0241	0.0379	0.0379
Echinococcus multilocularis	serotonin transporter	0.0155	0.0233	0.0704
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.003	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0511	0.0837	0.0837
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0511	0.0837	0.2532
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0511	0.0837	0.0837
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0511	0.0837	0.2224
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1967	0.3306	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0026	0.0015	0.0039
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0026	0.0015	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Brugia malayi	hypothetical protein	0.0026	0.0015	0.0015
Brugia malayi	hypothetical protein	0.027	0.0428	0.0428
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0026	0.0015	0.5
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0241	0.0379	0.0379
Brugia malayi	nuclear hormone receptor	0.0511	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.027	0.0428	0.0428
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0511	0.0837	0.0837
Brugia malayi	Nuclear hormone receptor-like 1	0.027	0.0428	0.0428
Schistosoma mansoni	thyroid hormone receptor	0.0511	0.0837	0.2224
Brugia malayi	hypothetical protein	0.0241	0.0379	0.0379
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0241	0.0379	0.1147
Brugia malayi	tailless protein	0.0241	0.0379	0.0379
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0241	0.0379	0.0365
Onchocerca volvulus		0.0054	0.0061	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0511	0.0837	0.0837
Echinococcus granulosus	serotonin transporter	0.0155	0.0233	0.0618
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0064	0.017
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0155	0.0233	0.0618
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0064	0.017
Schistosoma mansoni	nuclear hormone receptor	0.0511	0.0837	0.2224
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0511	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0263	0.0416	0.0416
Loa Loa (eye worm)	norepinephrine transporter	0.0155	0.0233	0.0233
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0026	0.0015	0.0039
Schistosoma mansoni	hypothetical protein	0.0188	0.029	0.077
Loa Loa (eye worm)	hypothetical protein	0.0511	0.0837	0.0837
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0064	0.017
Schistosoma mansoni	retinoic acid receptor RXR	0.2237	0.3765	1
Schistosoma mansoni	nuclear hormone receptor	0.0241	0.0379	0.1007
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0064	0.017
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0511	0.0837	0.0837
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0026	0.0015	0.0039
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0511	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0233	0.0233
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0511	0.0837	0.0837
Schistosoma mansoni	hypothetical protein	0.0038	0.0035	0.0092
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.0034	0.0104
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0362	0.0585	0.0585
Loa Loa (eye worm)	serotonin transporter b	0.0155	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0026	0.0015	0.5
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0511	0.0837	0.2224
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0511	0.0837	0.2224
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0511	0.0837	0.2224
Brugia malayi	nuclear hormone receptor	0.0241	0.0379	0.0379
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.004	0.0107
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0241	0.0379	0.0379
Mycobacterium ulcerans	short chain dehydrogenase	0.0541	0.0887	0.5
Toxoplasma gondii	hypothetical protein	0.0026	0.0015	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.027	0.0428	0.1138
Brugia malayi	steroid hormone receptor	0.0511	0.0837	0.0837
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0026	0.0015	0.0045
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0511	0.0837	0.0837
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0511	0.0837	0.0837
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0026	0.0015	0.5
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.027	0.0428	0.0428
Echinococcus granulosus	survival motor neuron protein 1	0.0263	0.0416	0.1105
Schistosoma mansoni	sodium/chloride dependent transporter	0.0155	0.0233	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0035	0.0035
Onchocerca volvulus		0.0155	0.0233	0.0218
Brugia malayi	orphan nuclear receptor NR2E1	0.0241	0.0379	0.0379
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0035	0.0035
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0511	0.0837	0.2224
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0241	0.0379	0.1147
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0064	0.0193
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0241	0.0379	0.1007
Schistosoma mansoni	sodium/chloride dependent transporter	0.0026	0.0015	0.0039
Onchocerca volvulus		0.0241	0.0379	0.0365
Onchocerca volvulus		0.0241	0.0379	0.0365
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0026	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Leishmania major	C-8 sterol isomerase-like protein	0.0362	0.0585	0.5
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0155	0.0233	0.0233
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0511	0.0837	0.0837
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.027	0.0428	0.0428
Schistosoma mansoni	thyroid hormone receptor	0.0511	0.0837	0.2224
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0241	0.0379	0.1147
Brugia malayi	Nuclear hormone receptor E75	0.0241	0.0379	0.0379
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0362	0.0585	0.5
Echinococcus multilocularis	survival motor neuron protein 1	0.0263	0.0416	0.1258
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0026	0.0015	0.0015
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0511	0.0837	0.2532
Brugia malayi	nuclear receptor NHR-88	0.0241	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.027	0.0428	0.0428
Loa Loa (eye worm)	DR-78	0.0241	0.0379	0.0379
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0511	0.0837	0.0837
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.003	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0064	0.0193
Brugia malayi	photoreceptor-specific nuclear receptor	0.0511	0.0837	0.0837
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0362	0.0585	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.027	0.0428	0.0428
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0241	0.0379	0.0379
Toxoplasma gondii	hypothetical protein	0.0026	0.0015	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0511	0.0837	0.2532
Loa Loa (eye worm)	hypothetical protein	0.0511	0.0837	0.0837
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0026	0.0015	0.0039
Brugia malayi	hypothetical protein	0.0263	0.0416	0.0416
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0511	0.0837	0.2532
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0511	0.0837	0.0837
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.2237	0.3765	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0511	0.0837	0.2224
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0511	0.0837	0.2532
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0026	0.0015	0.0039
Brugia malayi	Nuclear hormone receptor-like 1	0.027	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0511	0.0837	0.0837
Brugia malayi	hypothetical protein	0.027	0.0428	0.0428
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0511	0.0837	0.2224
Schistosoma mansoni	zinc finger protein	0.0241	0.0379	0.1007
Schistosoma mansoni	hypothetical protein	0.0188	0.029	0.077
Schistosoma mansoni	nuclear hormone receptor	0.0241	0.0379	0.1007
Plasmodium falciparum	amino acid transporter, putative	0.0026	0.0015	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0511	0.0837	0.0837
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0064	0.0064
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.004	0.0107
Brugia malayi	Nuclear hormone receptor E75	0.0241	0.0379	0.0379
Treponema pallidum	sodium- and chloride- dependent transporter	0.0155	0.0233	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.0015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0511	0.0837	0.0837
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0511	0.0837	0.2532
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.0015
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0511	0.0837	0.2224
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0026	0.0015	0.0015
Echinococcus multilocularis	geminin	0.0188	0.029	0.0876
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0511	0.0837	0.0837
Echinococcus granulosus	thyroid hormone receptor alpha	0.0241	0.0379	0.1007
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0026	0.0015	0.0039
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.0015	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.027	0.0428	0.1295
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0511	0.0837	0.2224
Echinococcus granulosus	nuclear receptor nhr 48	0.0241	0.0379	0.1007
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0241	0.0379	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0026	0.0026
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0511	0.0837	0.0837
Echinococcus granulosus	geminin	0.0188	0.029	0.077
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0511	0.0837	0.0837
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0511	0.0837	0.2532
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0026	0.0015	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0511	0.0837	0.0837
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0064	0.0064
Echinococcus multilocularis	FTZ F1 alpha	0.0511	0.0837	0.2532
Loa Loa (eye worm)	hypothetical protein	0.0362	0.0585	0.0585
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0511	0.0837	0.0837
Mycobacterium tuberculosis	Probable oxidoreductase	0.0541	0.0887	0.5
Onchocerca volvulus		0.0511	0.0837	0.0824
Loa Loa (eye worm)	hypothetical protein	0.5914	1	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0026	0.0015	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0511	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0015	0.0015
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0241	0.0379	0.0379
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0026	0.0015	0.0045
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0511	0.0837	0.2224
Brugia malayi	nuclear receptor RXR	0.027	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0233	0.0233
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0511	0.0837	0.0824
Brugia malayi	nuclear receptor RXR	0.0241	0.0379	0.0379
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0511	0.0837	0.2224
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0026	0.0015	0.0045
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0241	0.0379	0.1007
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0026	0.0015	0.0039
Schistosoma mansoni	hypothetical protein	0.0054	0.0061	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0511	0.0837	0.0837
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0064	0.017
Schistosoma mansoni	nuclear receptor nhr-48	0.0241	0.0379	0.1007
Schistosoma mansoni	sodium/chloride dependent transporter	0.0026	0.0015	0.0039
Loa Loa (eye worm)	steroid hormone receptor	0.0511	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0233	0.0233
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0026	0.0015	0.0039
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.027	0.0428	0.1138
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.027	0.0428	0.1138

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.8913 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2132566

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1707563