Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 0.5711 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0222 | 0.0389 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.4517 | 0.791 |
Schistosoma mansoni | alpha-glucosidase | 0.0122 | 0.1523 | 0.1523 |
Brugia malayi | ecdysteroid receptor | 0.0358 | 0.5711 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.06 | 1 | 1 |
Onchocerca volvulus | 0.0291 | 0.4517 | 0.791 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0151 | 0.2043 | 0.3577 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0142 | 0.1873 | 0.328 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0082 | 0.0814 | 0.1425 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2043 | 0.3577 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.023 | 0.3443 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0142 | 0.1873 | 0.1873 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0222 | 0.0222 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0142 | 0.1873 | 0.1873 |
Onchocerca volvulus | 0.0151 | 0.2043 | 0.3577 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0222 | 0.0222 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0222 | 0.0222 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0142 | 0.1873 | 0.1873 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0358 | 0.5711 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0122 | 0.1523 | 0.1523 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0222 | 0.0222 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0222 | 0.0222 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0142 | 0.1873 | 0.328 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0222 | 0.0389 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.06 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.4517 | 0.791 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0222 | 0.0222 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.